Evidence map›Paper›PMID 35793244›Full record

ArticleAging2022

Long non-coding RNA H19 contributes to spinal cord ischemia/reperfusion injury through increasing neuronal pyroptosis by miR-181a-5p/HMGB1 axis.

Lili Guo, Dan Wang, Hildrich Yasmal Alexander, Xiaoyan Ren, Hong Ma

Open access · hybridAbstract read
In one paragraph

Article in Aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Review
  3. Involvement of the pyroptosis-HMGB1 axis in systemic diseases.Frontiers in cell and developmental biology · 2026
    Review
  4. HMGB1: a multifaceted mediator of cell death pathways in cardiovascular diseases.Apoptosis : an international journal on programmed cell death · 2025
    Review
  5. LncRNAs Orchestrating Neuroinflammation: A Comprehensive Review.Cellular and molecular neurobiology · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. METTL3-mediated m6A modification enhances lncRNA H19 stability to promote endothelial cell inflammation and pyroptosis to aggravate atherosclerosis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Pyroptosis in spinal cord injury.Frontiers in cellular neuroscience · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Lili GuoDepartment of Anesthesiology, First Hospital of China Medical University, Shenyang 110001, Liaoning Province, China.
Dan WangDepartment of Anesthesiology, First Hospital of China Medical University, Shenyang 110001, Liaoning Province, China.
Hildrich Yasmal AlexanderDepartment of Anesthesiology, First Hospital of China Medical University, Shenyang 110001, Liaoning Province, China.
Xiaoyan RenDepartment of Anesthesiology, First Hospital of China Medical University, Shenyang 110001, Liaoning Province, China.
Hong MaDepartment of Anesthesiology, First Hospital of China Medical University, Shenyang 110001, Liaoning Province, China.
First Hospital of China Medical University · CNChina Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pyroptosis, a programmed inflammatory necrotizing cell death, is likely involved in spinal cord ischemia-reperfusion (SCI/R) injury, but the mechanisms initiating driving neuronal pyroptosis must be further revealed. The aim of this study is to unravel the mechanism of long non-coding RNA (lncRNA) H19 during SCI/R. SCI/R model was induced in C57BL/6 mice by blocking the aortic arch

Indexed as

HMGB1 ProteinMicroRNAsReperfusion InjuryRNA, Long NoncodingSpinal Cord IschemiaAnimalsApoptosisInflammationMiceMice, Inbred C57BLPyroptosisRatsH19 long non-coding RNAHMGB1 ProteinMicroRNAsRNA, Long NoncodingH19HMGB1miR-181a-5ppyroptosisspinal cord ischemia-reperfusion injury

Identifiers

PMID35793244
PMCPMC9320554
OpenAlexW4284683104

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.