ReviewMicrobial biotechnology2023
Rational engineering of natural polyhydroxyalkanoates producing microorganisms for improved synthesis and recovery.
Review in Microbial biotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Polyhydroxyalkanoates as multifaceted biopolymers: an eco-friendly alternative to conventional plastics.RSC advances · 2026Review
- LysR-type transcriptional regulator TtdR regulates both ethylene glycol and polyhydroxyalkanoate (PHA) metabolism in Pseudomonas umsongensis GO16.Applied microbiology and biotechnology · 2026Article
- Life cycle design of polyhydroxyalkanoates (PHA).National science review · 2025Review
- Isolation and characterization of a bacteria of Cupriavidus genus from Indian Himalayan region and its evaluation for production of Poly-3-hydroxybutyrate.Archives of microbiology · 2025Article
- Recent advances in engineering non-native microorganisms for poly(3-hydroxybutyrate) production.World journal of microbiology & biotechnology · 2025Review
- The role of biological nitrogen fixation in polyhydroxybutyrate production from methane by methane-oxidizing bacteria: a review of metabolic routes and yield enhancement.Frontiers in microbiology · 2025Review
- Microbial electrosynthesis meets synthetic biology: Bioproduction from waste feedstocks.Biotechnology notes (Amsterdam, Netherlands) · 2025Review
- Waste to wealth: Polyhydroxyalkanoates (PHA) production from food waste for a sustainable packaging paradigm.Food chemistry. Molecular sciences · 2024Article
- Synthetic biology toolkit of Ralstonia eutropha (Cupriavidus necator).Applied microbiology and biotechnology · 2024Review
- Advances in Microbial Biotechnology for Sustainable Alternatives to Petroleum-Based Plastics: A Comprehensive Review of Polyhydroxyalkanoate Production.Microorganisms · 2024Review
- Bioplastic Production from Agri-Food Waste through the Use ofMicroorganisms · 2024Review
- Production of biodegradable food packaging from mango peel via enzymatic hydrolysis and polyhydroxyalkanoates synthesis: A review on microbial intervention.Current research in microbial sciences · 2024Review
- Current trends in waste valorization.Microbial biotechnology · 2023Article
- Rational engineering of natural polyhydroxyalkanoates producing microorganisms for improved synthesis and recovery.Microbial biotechnology · 2023Review
- Microbes of traditional fermentation processes as synthetic biology chassis to tackle future food challenges.Frontiers in bioengineering and biotechnology · 2022Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Microbial production of biopolymers derived from renewable substrates and waste streams reduces our heavy reliance on petrochemical plastics. One of the most important biodegradable polymers is the family of polyhydroxyalkanoates (PHAs), naturally occurring intracellular polyoxoesters produced for decades by bacterial fermentation of sugars and fatty acids at the industrial scale. Despite the advances, PHA production still suffers from heavy costs associated with carbon substrates and downstream processing to recover the intracellular product, thus restricting market positioning. In recent years, model-aided metabolic engineering and novel synthetic biology approaches have spurred our understanding of carbon flux partitioning through competing pathways and cellular resource allocation during PHA synthesis, enabling the rational design of superior biopolymer producers and programmable cellular lytic systems. This review describes these attempts to rationally engineering the cellular operation of several microbes to elevate PHA production on specific substrates and waste products. We also delve into genome reduction, morphology, and redox cofactor engineering to boost PHA biosynthesis. Besides, we critically evaluate engineered bacterial strains in various fermentation modes in terms of PHA productivity and the period required for product recovery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.