Evidence map›Paper›PMID 35792687›Full record

ReviewObstetrical & gynecological survey2022

Venous Thromboembolism During Pregnancy and the Postpartum Period: Risk Factors, Diagnostic Testing, and Treatment.

Brandon C Maughan, Maria Marin, Justin Han, Karen J Gibbins, Anupama G Brixey, Aaron B Caughey, Jeffrey A Kline, Angela F Jarman

Open access · greenAbstract readReview
In one paragraph

Review in Obstetrical & gynecological survey, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
15.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 83 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Brandon C MaughanAssistant Professor, Department of Emergency Medicine, Oregon Health & Science University School of Medicine, Portland, OR.
Maria MarinMedical Student, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA.
Justin HanMedical Student, College of Medicine, Northeast Ohio Medical University, Rootstown, OH.
Karen J GibbinsAssistant Professor, Division of Perinatology, Department of Obstetrics and Gynecology.
Anupama G BrixeyAssistant Professor, Section of Cardiothoracic Imaging, Department of Diagnostic Radiology.
Aaron B CaugheyProfessor and Chair, Department of Obstetrics and Gynecology, Oregon Health & Science University School of Medicine, Portland, OR.
Jeffrey A KlineProfessor and Associate Chair of Research, Department of Emergency Medicine, Wayne State University, Detroit, MI.
Angela F JarmanAssistant Professor, Department of Emergency Medicine, University of California Davis, Davis, CA.
Oregon Health & Science University · USWestern University of Health Sciences · USInstitute Of Perinatology Obstetrics And Gynaecology · AMNortheast Ohio Medical University · USWayne State University · US

Funding

Building Interdisciplinary Research Careers in Womens Health at UC Davis - Administrative SupplementK12HD051958 · NICHD · UNIVERSITY OF CALIFORNIA DAVIS · PI LANE, NANCY E · 2005 to 2023
$9.6M
OHSU Women's Reproductive Health Research K12 ProgramK12HD085809 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Aaron B Caughey · 2015 to 2026
$4.0M
Building Interdisciplinary Research Careers in Women's Health at UC DavisK12AR084220 · NIAMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Nancy E Lane · 2023 to 2026
$3.0M
NIAMS NIH HHS K12 AR084220NICHD NIH HHS K12 HD051958NICHD NIH HHS K12 HD085809
6 · The paper itself

Abstract

Importance: The risk of venous thromboembolism (VTE) increases during pregnancy and the postpartum period. Deep vein thrombosis is the most common VTE during pregnancy, but pulmonary embolism is typically of greater concern as it contributes to far higher morbidity and mortality. Diagnosis and treatment of VTE during pregnancy differ substantially from the general nonpregnant population. Objective: This review describes the epidemiology, risk factors, clinical presentation, diagnosis, and treatment of VTE during pregnancy and the postpartum period. Evidence Acquisition: First, we reviewed the VTE guidelines from professional societies in obstetrics, cardiology, hematology, emergency medicine, pulmonology, and critical care. Second, we examined references from these documents and used PubMed to identify recent articles that cited the guidelines. Finally, we searched PubMed and Google Scholar for articles published since 2018 that included terms for pregnancy and the epidemiology, risk factors, diagnostic imaging, or treatment of VTE. Results: Venous thromboembolism risk increases throughout pregnancy and peaks shortly after delivery. More than half of pregnancy-related VTE are associated with thrombophilia; other major risks include cesarean delivery, postpartum infection, and the combination of obesity with immobilization. Most VTE can be treated with low molecular weight heparin, but cases of limb- or life-threatening VTE require consideration of thrombolysis and other reperfusion therapies. Conclusions and Relevance: Venous thromboembolism is far more frequent in antepartum and postpartum women than age-matched controls, and clinical suspicion for VTE in this population should incorporate pregnancy-specific risks. Treatment of limb- or life-threatening antepartum or postpartum VTE requires multispecialty coordination to optimize maternal and fetal outcomes.

Indexed as

Venous ThromboembolismDiagnostic Techniques and ProceduresFemaleHeparin, Low-Molecular-WeightHumansPostpartum PeriodPregnancyRisk FactorsHeparin, Low-Molecular-Weight

Identifiers

PMID35792687
PMCPMC10042329
OpenAlexW4283698705

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.