Trial reportAntimicrobial agents and chemotherapy1987
Erythromycin-resistant Campylobacter infections in Thailand.
Trial report in Antimicrobial agents and chemotherapy, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Consequences of Shigella infection in young children: a systematic review.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2023Pooled it
- Identification and management of Shigella infection in children with diarrhoea: a systematic review and meta-analysis.The Lancet. Global health · 2017Pooled it
- Prevalence and antimicrobial resistance ofOne health (Amsterdam, Netherlands) · 2025Review
- Prevalence, associated risk factors and antimicrobial susceptibility pattern of Campylobacter species among under five diarrheic children at Gondar University Hospital, Northwest Ethiopia.BMC pediatrics · 2013Article
- Antibiotic resistance in Campylobacter strains isolated from animals, foods, and humans in Spain in 1997-1998.Antimicrobial agents and chemotherapy · 2000Article
- Infection with ciprofloxacin-resistant Campylobacter jejuni in travellers returning from Asia.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 1996Article
- Susceptibilities to 10 antimicrobial agents of 1,220 Campylobacter strains isolated from 1987 to 1993 from feces of pediatric patients.Antimicrobial agents and chemotherapy · 1994Article
- Clinical aspects of Campylobacter jejuni infections in adults.The Western journal of medicine · 1994Review
- Susceptibilities of beta-lactamase-positive and -negative strains of Campylobacter coli to beta-lactam agents.Antimicrobial agents and chemotherapy · 1993Article
- In vitro activity of azithromycin against bacterial enteric pathogens.Antimicrobial agents and chemotherapy · 1993Article
- Emergence of resistance to erythromycin and fluoroquinolones in thermotolerant Campylobacter strains isolated from feces 1987-1991.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 1992Article
- Antimicrobial susceptibilities of Campylobacter jejuni and Campylobacter coli isolated in Sweden: a 10-year follow-up report.Antimicrobial agents and chemotherapy · 1992Article
- In vitro susceptibilities of aerotolerant Campylobacter isolates to 22 antimicrobial agents.Antimicrobial agents and chemotherapy · 1992Article
- Characterization of erythromycin resistance in Campylobacter jejuni and Campylobacter coli.Antimicrobial agents and chemotherapy · 1991Article
- Incidence of Campylobacter infection in infants in western Algeria and the possible protective role of breast feeding.Epidemiology and infection · 1990Article
- In vitro activities of tosufloxacin, temafloxacin, and A-56620 against pathogens of diarrhea.Antimicrobial agents and chemotherapy · 1990Article
- Mechanisms of antibiotic resistance in Campylobacter species.Antimicrobial agents and chemotherapy · 1988Review
- Influence of strain characteristics and immunity on the epidemiology of Campylobacter infections in Thailand.Journal of clinical microbiology · 1988Article
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Erythromycin therapy was compared with no treatment in a prospective trial of acute diarrheal disease among 100 infants in an orphanage in Bangkok. Within 24 h of the onset of diarrhea, 50 children received erythromycin ethylsuccinate (40 mg/kg per day) in four divided doses for 5 days. Campylobacter jejuni isolated from 31, Campylobacter coli isolated from 21, and Shigella spp. isolated from 21 of 100 children were the most commonly recognized pathogens; use of a sensitive, nonselective method substantially increased Campylobacter isolation. Treatment with erythromycin had no effect on the duration of diarrhea caused by Campylobacter spp., Shigella spp., or other agents; 37% of the treatment group and 35% of the control group had diarrhea for 1 week. Of 23 Campylobacter strains isolated from the treatment group before treatment, 15 (65%) were resistant (MIC, greater than or equal to 8 micrograms/ml) to erythromycin. Among orphanage-acquired strains, 53% of 43 C. jejuni strains and 91% of 23 C. coli strains were resistant to erythromycin compared with 11% of 114 C. jejuni strains and 46% of 35 C. coli strains that were community acquired. Erythromycin resistance is common among Campylobacter strains in Bangkok, especially in an institutional setting, which may account for the lack of efficacy of erythromycin for treatment of acute diarrheal illnesses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.