ReviewChest2023
Evaluation of Dyspnea and Exercise Intolerance After Acute Pulmonary Embolism.
Review in Chest, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
- Right ventricular strain analysis in acute pulmonary embolism and its role for late complications.European heart journal. Imaging methods and practice · 2026Article
- Review
- Chronic thromboembolism phenotypes after acute pulmonary embolism: identification with the SEARCH algorithm.The European respiratory journal · 2026Observational
- Functional recovery after pulmonary embolism: A pilot study using metabolic monitoring during the 6-minute walk test.Respiratory medicine · 2026Observational
- Post-Pulmonary Embolism Syndrome: New Phenotypes Come into Focus.Journal of clinical medicine · 2026Review
- How I treat pediatric pulmonary embolism.Blood · 2025Review
- Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension: Patient Selection, Procedural Pearls, and Expected Outcomes.Seminars in interventional radiology · 2025Review
- Cardiopulmonary Exercise Testing in People With Dyspnea With a Recent Acute Pulmonary Embolism.CHEST pulmonary · 2025Article
- Elevated risk of dyspnea in pediatric patients three months after pulmonary embolism.Respiratory medicine · 2025Article
- Acute Pulmonary Embolism: The Clinical Value of Early Follow-Up Computed Tomography Imaging in Thrombus Regression and Rare Differential Diagnoses of Pulmonary Intimal Sarcoma.Journal of atherosclerosis and thrombosis · 2025Article
- The Functional Characterization of Venous Thromboembolic Disease (FUVID) study: rationale, design, and methods of a prospective, observational, multicenter study to evaluate mechanisms of exercise intolerance and dyspnea following pediatric pulmonary embolism.Research and practice in thrombosis and haemostasis · 2025Article
- Sequelae of Acute Pulmonary Embolism: From Post-Pulmonary Embolism Functional Impairment to Chronic Thromboembolic Disease.Journal of clinical medicine · 2024Review
- Cardiopulmonary exercise testing following acute pulmonary embolism: Systematic review and pooled analysis of global studies.Pulmonary circulation · 2024Article
- Standardized Data Elements for Patients With Acute Pulmonary Embolism: A Consensus Report From the Pulmonary Embolism Research Collaborative.Circulation · 2024Review
- The occurrence mechanism, assessment, and non-pharmacological treatment of dyspnea.Medical review (2021) · 2024Review
- Pulmonary perfusion defects or residual vascular obstruction and persistent symptoms after pulmonary embolism: a systematic review and meta-analysis.ERJ open research · 2024Article
- Sildenafil improves hemodynamic changes caused by acute pulmonary embolism by inhibiting Rho kinase activity.The Journal of international medical research · 2024Article
- Cardiopulmonary exercise test to detect cardiac dysfunction from pulmonary vascular disease.Respiratory research · 2024Review
- Observational cohort study to validate SEARCH, a novel hierarchical algorithm to define long-term outcomes after pulmonary embolism.BMJ open · 2023Observational
- Cardiopulmonary exercise testing during follow-up after acute pulmonary embolism.The European respiratory journal · 2023Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Long-term dyspnea and exercise intolerance are common clinical problems after acute pulmonary embolism. Unfortunately, no single test can distinguish among the range of potential pathologic outcomes after pulmonary embolism. We illustrate a stepwise approach to post-pulmonary embolism evaluation that uses a hierarchic series of clinically validated diagnostic tests. The algorithm is represented by the acronym SEARCH, which stands for Symptom screening, Exercise testing, Arterial perfusion, Resting echocardiography, Confirmatory chest imaging, and Hemodynamics measured by right heart catheterization. We illustrate the algorithm with a patient whom we saw in our pulmonary embolism follow-up clinic. Patients are asked at least 6 months after pulmonary embolism whether they have returned to their baseline level of respiratory comfort and exercise tolerance. Patients with dyspnea and exercise intolerance undergo noninvasive cardiopulmonary exercise testing to identify elevated ventilatory dead space ratios, decreased stroke volume augmentation with exercise, and other physiologic abnormalities during exertion. Ventilation-perfusion scanning is performed on those patients with exercise-related physiologic findings to confirm the presence of residual pulmonary arterial obstruction or to suggest alternative diagnoses. Resting echocardiography may provide evidence of pulmonary hypertension; confirmatory imaging with pulmonary angiography or CT angiography may disclose findings characteristic of chronic pulmonary artery obstruction. Finally, right heart catheterization is performed to confirm chronic thromboembolic pulmonary hypertension; if resting pulmonary hemodynamics are normal, then invasive cardiopulmonary exercise testing may disclose exercise-induced defects.
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