Evidence map›Paper›PMID 35792050›Full record

ArticleAddiction (Abingdon, England)2022

Definition matters: assessment of tolerance to the effects of alcohol in a prospective cohort study of emerging adults.

Siobhan M O'Dean, Louise Mewton, Tammy Chung, Peter Clay, Philip J Clare, Raimondo Bruno, Wing See Yuen, Nyanda McBride, Wendy Swift, Ashling Isik and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Addiction (Abingdon, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 7 citations in OpenAlex.

  1. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2026
    Guideline
  2. Screening for high-risk drinking and alcohol use disorder: update of the 2023 national clinical practice guideline.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2026
    Guideline
  3. Chronic Alcoholism and Propofol Demand: The Impact of Alcohol Tolerance in Painless Gastrointestinal Endoscopy.JGH open : an open access journal of gastroenterology and hepatology · 2025
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 2 countries.

Siobhan M O'DeanThe Matilda Centre for Research in Mental Health and Substance Use, University of Sydney, Sydney, Australia.ORCID 0000-0002-5898-2065
Louise MewtonCentre for Healthy Brain Ageing, University of New South Wales, Sydney, NSW, Australia.ORCID 0000-0002-7812-296X
Tammy ChungDepartment of Psychiatry, Rutgers, The State University of New Jersey, Institute for Health, Healthcare Policy and Aging Research, New Jersey, USA.
Peter ClayThe Matilda Centre for Research in Mental Health and Substance Use, University of Sydney, Sydney, Australia.
Philip J ClarePrevention Research Collaboration, University of Sydney, Sydney, Australia.ORCID 0000-0002-2009-7386
Raimondo BrunoNational Drug and Alcohol Research Centre, UNSW, Sydney, Australia.
Wing See YuenNational Drug and Alcohol Research Centre, UNSW, Sydney, Australia.ORCID 0000-0002-2791-6858
Nyanda McBrideNational Drug Research Institute and enAble Institute, Curtin University, Perth, Australia.ORCID 0000-0003-1714-6631
Wendy SwiftAW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, Camperdown, NSW, Australia.
Ashling IsikThe Matilda Centre for Research in Mental Health and Substance Use, University of Sydney, Sydney, Australia.
Emily UptonNational Drug and Alcohol Research Centre, UNSW, Sydney, Australia.
Joel TibbettsThe Matilda Centre for Research in Mental Health and Substance Use, University of Sydney, Sydney, Australia.
Phoebe JohnsonThe Matilda Centre for Research in Mental Health and Substance Use, University of Sydney, Sydney, Australia.
Kypros KypriSchool of Medicine and Public Health, University of Newcastle, NSW, Australia.ORCID 0000-0002-9657-9904
Tim SladeThe Matilda Centre for Research in Mental Health and Substance Use, University of Sydney, Sydney, Australia.ORCID 0000-0002-1725-9188
The University of Sydney · AUUNSW Sydney · AUCurtin University · AURoyal Prince Alfred Hospital · AURutgers, The State University of New Jersey · USUniversity of Newcastle Australia · AUUniversity of Tasmania · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsTolerance to the effects of alcohol is an important element in the diagnosis of alcohol use disorders (AUD); however, there is ongoing debate about its utility in the diagnosis AUD in adolescents and young adults. This study aimed to refine the assessment of tolerance in young adults by testing different definitions of tolerance and their associations with longitudinal AUD outcomes.

designProspective cohort study. SETTINGS: Australia.

participantsA contemporary cohort of emerging adults across Australia (n = 565, mean age = 18.9, range = 18-21 at baseline). MEASUREMENTS: Clinician-administered Structured Clinical Interview for DSM-IV Research Version (SCID-IV-RV) assessed for AUD criteria across five interviews, at 6-month intervals over 2.5 years. Tolerance definitions were operationalized using survey-type response (yes/no), clinician judgement (SCID-IV-RV), different initial drinking quantity and percentage increase thresholds and average heavy consumption metrics. AUD persistence was operationalized by the number of times AUD was present across the 2.5-year study period (n = 491), and new-onset AUD was operationalized as any new incidence of AUD during the follow-up period (n = 461).

findingsThe (i) SCID-IV-RV clinician judgement [odds ratio (OR) = 2.50, P = 0.005], (ii) an initial drinking quantity threshold of four to five drinks and 50% minimum increase (OR = 2.48, P = 0.007) and (iii) 50% increase only (OR = 2.40, P = 0.005) were the tolerance definitions more strongly associated with any new onset of AUD throughout the four follow-up time-points than other definitions. However, these definitions were not associated with persistent AUD (Ps > 0.05). Average heavy consumption definitions of tolerance were most strongly associated with persistent AUD (OR = 6.66, P = 0.001; OR = 4.65, P = 0.004) but not associated with new-onset AUD (Ps > 0.05).

conclusionsInitial drink and percentage change thresholds appear to improve the efficacy of change-based tolerance as an indicator for new-onset alcohol use disorder diagnosis in self-report surveys of young adults. When predicting persistent alcohol use disorder, average heavy consumption-based indicators appear to be a better way to measure tolerance than self-reported change-based definitions.

Indexed as

AlcoholismAlcohol-Related DisordersAdolescentAlcohol DrinkingEthanolHumansProspective StudiesYoung AdultEthanolAdolescentsalcoholalcohol use disordercohort studytoleranceyoung adult

Identifiers

PMID35792050
PMCPMC9796318
OpenAlexW4283827510

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.