Evidence map›Paper›PMID 35791806›Full record

ArticleJournal of the American Geriatrics Society2022

Perception of atrial fibrillation symptoms: Impact on quality of life and treatment in older adults.

Hawa O Abu, Weijia Wang, Edith M Otabil, Jane S Saczynski, Jordy Mehawej, Ajay Mishra, Mayra Tisminetzky, Gary Blanchard, Jerry H Gurwitz, Robert J Goldberg and 1 more

Open access · greenAbstract readMulticenter Study
In one paragraph

Article in Journal of the American Geriatrics Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Trial
  2. Brazilian Atrial Fibrillation Guidelines - 2025.Arquivos brasileiros de cardiologia · 2025
    Article
  3. Identifying potential action points for reducing kinesiophobia among atrial fibrillation patients: a network and DAG analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025
    Article
  4. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Hawa O AbuDivision of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.ORCID 0000-0002-9359-7373
Weijia WangDivision of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.ORCID 0000-0002-9435-0145
Edith M OtabilDivision of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Jane S SaczynskiDepartment of Pharmacy and Health Systems Sciences, School of Pharmacy, Northeastern University, Boston, Massachusetts, USA.
Jordy MehawejDivision of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Ajay MishraDepartment of Internal Medicine, Saint Vincent Hospital, Worcester, Massachusetts, USA.
Mayra TisminetzkyDivision of Geriatric Medicine and Meyers Health Care Institute. Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Gary BlanchardDivision of Geriatrics, Department of Internal Medicine, Saint Vincent Hospital, Worcester, Massachusetts, USA.
Jerry H GurwitzDivision of Geriatric Medicine and Meyers Health Care Institute. Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Robert J GoldbergDepartment of Population and Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
David D McManusDivision of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
University of Massachusetts Chan Medical School · USSaint Vincent Hospital · USNortheastern University · US

Funding

Preparing For What Is Next With Aducanumab In Real World SettingsR33AG057806 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Christopher Barrett Bowling, Ana Roman Quinones · 2018 to 2026
$9.0M
Transdisciplinary Training In Cardiovascular ResearchT32HL120823 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DONAHUE, J KEVIN, KIEFE, CATARINA I. · 2014 to 2025
$3.9M
Detecting bleeding events using EHRs for prediction in AfibR01HL137794 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI MCMANUS, DAVID D., YU, HONG · 2018 to 2021
$3.3M
Systematic Assessment of Geriatric Elements in Atrial Fibrillation (SAGE-AF)R01HL126911 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI MCMANUS, DAVID D., SACZYNSKI, JANE STEELE · 2016 to 2019
$3.2M
Smartwatch Monitoring for Atrial Fibrillation After StrokeR01HL137734 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI CHON, KI H, MCMANUS, DAVID D. · 2018 to 2021
$3.1M
FHS-NEXT - Framingham Novel EXam using TechnologyR01HL141434 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BENJAMIN, EMELIA J., MCMANUS, DAVID D. · 2019 to 2022
$2.5M
Multimorbidity and Treatment-Related Outcomes in Older Heart Failure PatientsR01AG062630 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI TISMINETZKY, MAYRA S. · 2019 to 2022
$2.4M
NHLBI NIH HHS R01 HL126911NHLBI NIH HHS R01HL13660NHLBI NIH HHS R01 HL137734NHLBI NIH HHS R01 HL137794NHLBI NIH HHS R01 HL141434NHLBI NIH HHS T32 HL120823NIA NIH HHS R01 AG062630NIA NIH HHS R33 AG057806
6 · The paper itself

Abstract

backgroundIn managing older adults with atrial fibrillation (AF), their symptomatology impacts their well-being and may inform treatment decision-making. We examined AF symptom perception, its impact on quality of life (QoL), and its relation to treatment strategies in older adults with AF.

methodsData were obtained from older adults with AF enrolled in a multicenter study conducted at clinic sites in Massachusetts and Georgia between 2016 and 2018. Participants were stratified into three age groups: 65-74 (youngest-old), 75-84 (middle-old), and ≥85 (oldest). Perception of AF symptoms was assessed by participant self-report during their clinic visit and at study enrollment by the Atrial Fibrillation Effect on Quality-of-Life Questionnaire which assessed cardiac-specific and non-specific, non-cardiac AF symptoms and their impact on QoL. Treatment strategies (rate or rhythm control) utilized were ascertained from electronic medical records.

resultsAmong the 1184 participants (mean age 75 years, 48% women, 86% Non-Hispanic White), 51% were aged 65-74 years, 36% were 75-84 years, and 13% were ≥ 85 years. The most commonly reported AF symptoms were non-specific, non-cardiac symptoms (fatigue, dyspnea, lightheadedness) with similar prevalence and impact on QoL in all age groups. Cardiac-specific AF symptoms (palpitations, irregular heartbeat, pause in heart activity) were less prevalent, but most commonly reported by the youngest participants (65-74 years), who endorsed considerable impact of these symptoms on their QoL. Overall, those who reported experiencing any AF symptoms during their clinic visit were more likely to have received rhythm compared with rate control (OR: 1.56; 95% CI: 1.18-2.04) with similar findings for all age groups except those aged ≥85 years.

conclusionsOur findings suggest a high prevalence of non-specific, non-cardiac symptoms among older adults with AF and that cardiac-specific AF symptoms may exert considerable impact on their QoL. The presence of any AF symptoms may drive more rhythm control in a majority of older adults.

Indexed as

Atrial FibrillationAgedFemaleHumansMalePerceptionQuality of LifeSelf ReportSurveys and Questionnairesatrial fibrillationolder adultsquality of life

Identifiers

PMID35791806
PMCPMC9588564
OpenAlexW4284702536

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.