Evidence map›Paper›PMID 35791633›Full record

ArticleASN neuro

Lanthionine Ketimine Ethyl Ester Accelerates Remyelination in a Mouse Model of Multiple Sclerosis.

Jeffrey L Dupree, Pablo M Paez, Seema K Tiwari-Woodruff, Travis T Denton, Kenneth Hensley, Christina G Angeliu, Anne I Boullerne, Sergey Kalinin, Sophia Egge, Veronica T Cheli and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ASN neuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Fisetin Mitigates Ferroptosis and Promotes Remyelination in a Cuprizone Model of Multiple Sclerosis.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Remyelination in Multiple Sclerosis: Findings in the Cuprizone Model.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jeffrey L DupreeDepartment of Anatomy and Neurobiology, 6889Virginia Commonwealth University, Richmond, VA, USA.
Pablo M PaezInstitute for Myelin and Glia Exploration, Department of Pharmacology and Toxicology, 12292University at Buffalo, NY, USA.ORCID 0000-0001-9362-9454
Seema K Tiwari-WoodruffDivision of Biomedical Sciences, 8790School of Medicine at the University of California Riverside, Riverside, CA, USA.ORCID 0000-0001-7608-4763
Travis T DentonDepartment of Pharmaceutical Sciences, College of Pharmacy & Pharmaceutical Sciences, Washington State University Health Sciences Spokane, Spokane, WA, USA.
Kenneth Hensley477020Arkansas College of Osteopathic Medicine, Fort Smith, AR, USA.
Christina G AngeliuInstitute for Myelin and Glia Exploration, Department of Pharmacology and Toxicology, 12292University at Buffalo, NY, USA.
Anne I BoullerneDepartment Anesthesiology, University of Illinois, Chicago, IL, USA.
Sergey KalininDepartment Anesthesiology, University of Illinois, Chicago, IL, USA.
Sophia EggeDepartment of Anatomy and Neurobiology, 6889Virginia Commonwealth University, Richmond, VA, USA.
Veronica T CheliInstitute for Myelin and Glia Exploration, Department of Pharmacology and Toxicology, 12292University at Buffalo, NY, USA.
Giancarlo DenarosoInstitute for Myelin and Glia Exploration, Department of Pharmacology and Toxicology, 12292University at Buffalo, NY, USA.
Kelley C AtkinsonDivision of Biomedical Sciences, 8790School of Medicine at the University of California Riverside, Riverside, CA, USA.
Micah FeriDivision of Biomedical Sciences, 8790School of Medicine at the University of California Riverside, Riverside, CA, USA.
Douglas L FeinsteinDepartment Anesthesiology, University of Illinois, Chicago, IL, USA.ORCID 0000-0003-2815-2885

Funding

Demyelination is coupled to neuronal hyperexcitability leading to seizuresR01NS111552 · NINDS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI BINDER, DEVIN K, TIWARI-WOODRUFF, SEEMA K · 2020 to 2024
$1.9M
Stimulating oligodendrocyte progenitor cell differentiation and remyelinationR01NS081141 · NINDS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI TIWARI-WOODRUFF, SEEMA K · 2014 to 2017
$1.3M
BLR&D Research Career Scientist Award ApplicationIK6BX004852 · VA · JESSE BROWN VA MEDICAL CENTER · PI Douglas L. Feinstein · 2020 to 2026
–
BLRD VA I01 BX002565BLRD VA IK6 BX004852NINDS NIH HHS R01 NS081141NINDS NIH HHS R01 NS111552
6 · The paper itself

Abstract

Although over 20 disease modifying therapies are approved to treat Multiple Sclerosis (MS), these do not increase remyelination of demyelinated axons or mitigate axon damage. Previous studies showed that lanthionine ketenamine ethyl ester (LKE) reduces clinical signs in the experimental autoimmune encephalomyelitis (EAE) mouse model of MS and increased maturation of oligodendrocyte (OL) progenitor cells (OPCs)

Indexed as

Encephalomyelitis, Autoimmune, ExperimentalMultiple SclerosisRemyelinationAmino Acids, SulfurAnimalsCuprizoneDisease Models, AnimalEstersMiceRNA, MessengerAmino Acids, SulfurCuprizoneEsterslanthionine ketimineRNA, Messengerdemyelination < NEURO degenerationmyelination < NEURO developmentoligodendrocytes < NEURO gliaregeneration < NEURO repair

Identifiers

PMID35791633
PMCPMC9272172

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.