ArticleThe American journal of psychiatry2022
Decoding Shared Versus Divergent Transcriptomic Signatures Across Cortico-Amygdala Circuitry in PTSD and Depressive Disorders.
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Article in The American journal of psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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41citing papers in PubMed, 1 pooled it
5.9field-weighted citation impact, top 2% of its field
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder.Nature genetics · 2024Pooled it
- BDNF-DT and BDNF-AS-DT: novel genes in the BDNF locus.Molecular psychiatry · 2026Article
- Co-expression-based models improve eQTL predictions for transcriptome-wide association studies and highlight new schizophrenia-associated genes.Nature genetics · 2026Article
- Fine mapping of PTSD GWAS reveals a role for amygdalabioRxiv : the preprint server for biology · 2026Article
- Spatio-molecular gene expression reflects dorsal anterior cingulate cortex structure and function in the human brain.Cell reports · 2026Article
- Neuroimmune mechanisms in PTSD: inflammatory heterogeneity, circuit dysfunction, and biomarker-based subtypes.Molecular biology reports · 2026Review
- Behavioral and psychological symptoms of dementia: insights from a multivariate and network-based brain proteome-wide study.medRxiv : the preprint server for health sciences · 2026Article
- Cortistatin neurons in the prelimbic cortex regulate seizure susceptibility in female mice via BDNF-TrkB signaling.bioRxiv : the preprint server for biology · 2026Article
- Leveraging genomic and transcriptomic data of diverse ancestry to uncover mechanisms of psychiatric risk in the adult and developing brain.Nature communications · 2025Article
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- Integrating Aversive Memories in the Basolateral Amygdala.Biological psychiatry · 2025Review
- Transcriptomic Analysis of the Human Habenula in Schizophrenia.The American journal of psychiatry · 2025Article
- Transcriptomic diversity of amygdalar subdivisions across humans and nonhuman primates.Science advances · 2025Article
- The overlapping genetic architecture of psychiatric disorders and cortical brain structure.Nature. Mental health · 2025Article
- Shared Genetic Architecture Among Severe Mental Disorders: A System Biology Approach Based on Protein-Protein Interaction.Brain and behavior · 2025Article
- Single-nucleus chromatin accessibility profiling identifies cell types and functional variants contributing to major depression.Nature genetics · 2025Article
- Article
- A multi-omic approach implicates novel protein dysregulation in post-traumatic stress disorder.Genome medicine · 2025Article
- Molecular profiles in amygdala relevant to the relief of chronic unpredicted mild stress-induced depression by periodic meeting confidantes.Social cognitive and affective neuroscience · 2025Article
- Sex-specific gene expression and weighted co-expression network analysis suggest distinct sex-specific molecular signatures in acutely suicidal MDD-patients without somatic comorbidities.Frontiers in genetics · 2025Article
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Authors and funding
16 authors at 1 institution in 1 country.
Andrew E JaffeLieber Institute for Brain Development, Baltimore (Jaffe, Tao, Page, Maynard, Pattie, Nguyen, Deep-Soboslay, Bharadwaj, Shin, Hyde, Martinowich, Kleinman); Department of Neuroscience (Jaffe, Martinowich), Department of Genetic Medicine, McKusick-Nathans Institute of Genetic Medicine (Jaffe), and Department of Psychiatry and Behavioral Sciences (Jaffe, Hyde, Martinowich, Kleinman), Johns Hopkins University School of Medicine, Baltimore; Center for Computational Biology, Johns Hopkins University, Baltimore (Jaffe); Department of Biostatistics and Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Jaffe); Department of Psychiatry and Behavioral Sciences, Texas A&M College of Medicine, Bryan, Tex., Department of Veterans Affairs, VISN 17 Center of Excellence for Research on Returning War Veterans, Waco, Tex., Central Texas Veterans Health Care System, Temple, Tex., and Baylor Scott & White Psychiatry, Temple, Tex. (Young); Department of Psychiatry, Geisel School of Medicine at Dartmouth, Hanover, N.H. (Friedman); National Center for PTSD, U.S. Department of Veterans Affairs (Friedman); Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, N.C. (Williamson); Durham VA Health Care System, Durham, N.C. (Williamson); Department of Neurology, Johns Hopkins School of Medicine, Baltimore (Hyde).
Ran TaoLieber Institute for Brain Development, Baltimore (Jaffe, Tao, Page, Maynard, Pattie, Nguyen, Deep-Soboslay, Bharadwaj, Shin, Hyde, Martinowich, Kleinman); Department of Neuroscience (Jaffe, Martinowich), Department of Genetic Medicine, McKusick-Nathans Institute of Genetic Medicine (Jaffe), and Department of Psychiatry and Behavioral Sciences (Jaffe, Hyde, Martinowich, Kleinman), Johns Hopkins University School of Medicine, Baltimore; Center for Computational Biology, Johns Hopkins University, Baltimore (Jaffe); Department of Biostatistics and Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Jaffe); Department of Psychiatry and Behavioral Sciences, Texas A&M College of Medicine, Bryan, Tex., Department of Veterans Affairs, VISN 17 Center of Excellence for Research on Returning War Veterans, Waco, Tex., Central Texas Veterans Health Care System, Temple, Tex., and Baylor Scott & White Psychiatry, Temple, Tex. (Young); Department of Psychiatry, Geisel School of Medicine at Dartmouth, Hanover, N.H. (Friedman); National Center for PTSD, U.S. Department of Veterans Affairs (Friedman); Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, N.C. (Williamson); Durham VA Health Care System, Durham, N.C. (Williamson); Department of Neurology, Johns Hopkins School of Medicine, Baltimore (Hyde).
Stephanie C PageLieber Institute for Brain Development, Baltimore (Jaffe, Tao, Page, Maynard, Pattie, Nguyen, Deep-Soboslay, Bharadwaj, Shin, Hyde, Martinowich, Kleinman); Department of Neuroscience (Jaffe, Martinowich), Department of Genetic Medicine, McKusick-Nathans Institute of Genetic Medicine (Jaffe), and Department of Psychiatry and Behavioral Sciences (Jaffe, Hyde, Martinowich, Kleinman), Johns Hopkins University School of Medicine, Baltimore; Center for Computational Biology, Johns Hopkins University, Baltimore (Jaffe); Department of Biostatistics and Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Jaffe); Department of Psychiatry and Behavioral Sciences, Texas A&M College of Medicine, Bryan, Tex., Department of Veterans Affairs, VISN 17 Center of Excellence for Research on Returning War Veterans, Waco, Tex., Central Texas Veterans Health Care System, Temple, Tex., and Baylor Scott & White Psychiatry, Temple, Tex. (Young); Department of Psychiatry, Geisel School of Medicine at Dartmouth, Hanover, N.H. (Friedman); National Center for PTSD, U.S. Department of Veterans Affairs (Friedman); Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, N.C. (Williamson); Durham VA Health Care System, Durham, N.C. (Williamson); Department of Neurology, Johns Hopkins School of Medicine, Baltimore (Hyde).
Kristen R MaynardLieber Institute for Brain Development, Baltimore (Jaffe, Tao, Page, Maynard, Pattie, Nguyen, Deep-Soboslay, Bharadwaj, Shin, Hyde, Martinowich, Kleinman); Department of Neuroscience (Jaffe, Martinowich), Department of Genetic Medicine, McKusick-Nathans Institute of Genetic Medicine (Jaffe), and Department of Psychiatry and Behavioral Sciences (Jaffe, Hyde, Martinowich, Kleinman), Johns Hopkins University School of Medicine, Baltimore; Center for Computational Biology, Johns Hopkins University, Baltimore (Jaffe); Department of Biostatistics and Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Jaffe); Department of Psychiatry and Behavioral Sciences, Texas A&M College of Medicine, Bryan, Tex., Department of Veterans Affairs, VISN 17 Center of Excellence for Research on Returning War Veterans, Waco, Tex., Central Texas Veterans Health Care System, Temple, Tex., and Baylor Scott & White Psychiatry, Temple, Tex. (Young); Department of Psychiatry, Geisel School of Medicine at Dartmouth, Hanover, N.H. (Friedman); National Center for PTSD, U.S. Department of Veterans Affairs (Friedman); Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, N.C. (Williamson); Durham VA Health Care System, Durham, N.C. (Williamson); Department of Neurology, Johns Hopkins School of Medicine, Baltimore (Hyde).
Elizabeth A PattieLieber Institute for Brain Development, Baltimore (Jaffe, Tao, Page, Maynard, Pattie, Nguyen, Deep-Soboslay, Bharadwaj, Shin, Hyde, Martinowich, Kleinman); Department of Neuroscience (Jaffe, Martinowich), Department of Genetic Medicine, McKusick-Nathans Institute of Genetic Medicine (Jaffe), and Department of Psychiatry and Behavioral Sciences (Jaffe, Hyde, Martinowich, Kleinman), Johns Hopkins University School of Medicine, Baltimore; Center for Computational Biology, Johns Hopkins University, Baltimore (Jaffe); Department of Biostatistics and Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Jaffe); Department of Psychiatry and Behavioral Sciences, Texas A&M College of Medicine, Bryan, Tex., Department of Veterans Affairs, VISN 17 Center of Excellence for Research on Returning War Veterans, Waco, Tex., Central Texas Veterans Health Care System, Temple, Tex., and Baylor Scott & White Psychiatry, Temple, Tex. (Young); Department of Psychiatry, Geisel School of Medicine at Dartmouth, Hanover, N.H. (Friedman); National Center for PTSD, U.S. Department of Veterans Affairs (Friedman); Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, N.C. (Williamson); Durham VA Health Care System, Durham, N.C. (Williamson); Department of Neurology, Johns Hopkins School of Medicine, Baltimore (Hyde).
Claudia V NguyenLieber Institute for Brain Development, Baltimore (Jaffe, Tao, Page, Maynard, Pattie, Nguyen, Deep-Soboslay, Bharadwaj, Shin, Hyde, Martinowich, Kleinman); Department of Neuroscience (Jaffe, Martinowich), Department of Genetic Medicine, McKusick-Nathans Institute of Genetic Medicine (Jaffe), and Department of Psychiatry and Behavioral Sciences (Jaffe, Hyde, Martinowich, Kleinman), Johns Hopkins University School of Medicine, Baltimore; Center for Computational Biology, Johns Hopkins University, Baltimore (Jaffe); Department of Biostatistics and Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Jaffe); Department of Psychiatry and Behavioral Sciences, Texas A&M College of Medicine, Bryan, Tex., Department of Veterans Affairs, VISN 17 Center of Excellence for Research on Returning War Veterans, Waco, Tex., Central Texas Veterans Health Care System, Temple, Tex., and Baylor Scott & White Psychiatry, Temple, Tex. (Young); Department of Psychiatry, Geisel School of Medicine at Dartmouth, Hanover, N.H. (Friedman); National Center for PTSD, U.S. Department of Veterans Affairs (Friedman); Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, N.C. (Williamson); Durham VA Health Care System, Durham, N.C. (Williamson); Department of Neurology, Johns Hopkins School of Medicine, Baltimore (Hyde).
Amy Deep-SoboslayLieber Institute for Brain Development, Baltimore (Jaffe, Tao, Page, Maynard, Pattie, Nguyen, Deep-Soboslay, Bharadwaj, Shin, Hyde, Martinowich, Kleinman); Department of Neuroscience (Jaffe, Martinowich), Department of Genetic Medicine, McKusick-Nathans Institute of Genetic Medicine (Jaffe), and Department of Psychiatry and Behavioral Sciences (Jaffe, Hyde, Martinowich, Kleinman), Johns Hopkins University School of Medicine, Baltimore; Center for Computational Biology, Johns Hopkins University, Baltimore (Jaffe); Department of Biostatistics and Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Jaffe); Department of Psychiatry and Behavioral Sciences, Texas A&M College of Medicine, Bryan, Tex., Department of Veterans Affairs, VISN 17 Center of Excellence for Research on Returning War Veterans, Waco, Tex., Central Texas Veterans Health Care System, Temple, Tex., and Baylor Scott & White Psychiatry, Temple, Tex. (Young); Department of Psychiatry, Geisel School of Medicine at Dartmouth, Hanover, N.H. (Friedman); National Center for PTSD, U.S. Department of Veterans Affairs (Friedman); Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, N.C. (Williamson); Durham VA Health Care System, Durham, N.C. (Williamson); Department of Neurology, Johns Hopkins School of Medicine, Baltimore (Hyde).
Rahul BharadwajLieber Institute for Brain Development, Baltimore (Jaffe, Tao, Page, Maynard, Pattie, Nguyen, Deep-Soboslay, Bharadwaj, Shin, Hyde, Martinowich, Kleinman); Department of Neuroscience (Jaffe, Martinowich), Department of Genetic Medicine, McKusick-Nathans Institute of Genetic Medicine (Jaffe), and Department of Psychiatry and Behavioral Sciences (Jaffe, Hyde, Martinowich, Kleinman), Johns Hopkins University School of Medicine, Baltimore; Center for Computational Biology, Johns Hopkins University, Baltimore (Jaffe); Department of Biostatistics and Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Jaffe); Department of Psychiatry and Behavioral Sciences, Texas A&M College of Medicine, Bryan, Tex., Department of Veterans Affairs, VISN 17 Center of Excellence for Research on Returning War Veterans, Waco, Tex., Central Texas Veterans Health Care System, Temple, Tex., and Baylor Scott & White Psychiatry, Temple, Tex. (Young); Department of Psychiatry, Geisel School of Medicine at Dartmouth, Hanover, N.H. (Friedman); National Center for PTSD, U.S. Department of Veterans Affairs (Friedman); Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, N.C. (Williamson); Durham VA Health Care System, Durham, N.C. (Williamson); Department of Neurology, Johns Hopkins School of Medicine, Baltimore (Hyde).
Keith A YoungLieber Institute for Brain Development, Baltimore (Jaffe, Tao, Page, Maynard, Pattie, Nguyen, Deep-Soboslay, Bharadwaj, Shin, Hyde, Martinowich, Kleinman); Department of Neuroscience (Jaffe, Martinowich), Department of Genetic Medicine, McKusick-Nathans Institute of Genetic Medicine (Jaffe), and Department of Psychiatry and Behavioral Sciences (Jaffe, Hyde, Martinowich, Kleinman), Johns Hopkins University School of Medicine, Baltimore; Center for Computational Biology, Johns Hopkins University, Baltimore (Jaffe); Department of Biostatistics and Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Jaffe); Department of Psychiatry and Behavioral Sciences, Texas A&M College of Medicine, Bryan, Tex., Department of Veterans Affairs, VISN 17 Center of Excellence for Research on Returning War Veterans, Waco, Tex., Central Texas Veterans Health Care System, Temple, Tex., and Baylor Scott & White Psychiatry, Temple, Tex. (Young); Department of Psychiatry, Geisel School of Medicine at Dartmouth, Hanover, N.H. (Friedman); National Center for PTSD, U.S. Department of Veterans Affairs (Friedman); Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, N.C. (Williamson); Durham VA Health Care System, Durham, N.C. (Williamson); Department of Neurology, Johns Hopkins School of Medicine, Baltimore (Hyde).
Matthew J FriedmanLieber Institute for Brain Development, Baltimore (Jaffe, Tao, Page, Maynard, Pattie, Nguyen, Deep-Soboslay, Bharadwaj, Shin, Hyde, Martinowich, Kleinman); Department of Neuroscience (Jaffe, Martinowich), Department of Genetic Medicine, McKusick-Nathans Institute of Genetic Medicine (Jaffe), and Department of Psychiatry and Behavioral Sciences (Jaffe, Hyde, Martinowich, Kleinman), Johns Hopkins University School of Medicine, Baltimore; Center for Computational Biology, Johns Hopkins University, Baltimore (Jaffe); Department of Biostatistics and Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Jaffe); Department of Psychiatry and Behavioral Sciences, Texas A&M College of Medicine, Bryan, Tex., Department of Veterans Affairs, VISN 17 Center of Excellence for Research on Returning War Veterans, Waco, Tex., Central Texas Veterans Health Care System, Temple, Tex., and Baylor Scott & White Psychiatry, Temple, Tex. (Young); Department of Psychiatry, Geisel School of Medicine at Dartmouth, Hanover, N.H. (Friedman); National Center for PTSD, U.S. Department of Veterans Affairs (Friedman); Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, N.C. (Williamson); Durham VA Health Care System, Durham, N.C. (Williamson); Department of Neurology, Johns Hopkins School of Medicine, Baltimore (Hyde).
Douglas E WilliamsonLieber Institute for Brain Development, Baltimore (Jaffe, Tao, Page, Maynard, Pattie, Nguyen, Deep-Soboslay, Bharadwaj, Shin, Hyde, Martinowich, Kleinman); Department of Neuroscience (Jaffe, Martinowich), Department of Genetic Medicine, McKusick-Nathans Institute of Genetic Medicine (Jaffe), and Department of Psychiatry and Behavioral Sciences (Jaffe, Hyde, Martinowich, Kleinman), Johns Hopkins University School of Medicine, Baltimore; Center for Computational Biology, Johns Hopkins University, Baltimore (Jaffe); Department of Biostatistics and Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Jaffe); Department of Psychiatry and Behavioral Sciences, Texas A&M College of Medicine, Bryan, Tex., Department of Veterans Affairs, VISN 17 Center of Excellence for Research on Returning War Veterans, Waco, Tex., Central Texas Veterans Health Care System, Temple, Tex., and Baylor Scott & White Psychiatry, Temple, Tex. (Young); Department of Psychiatry, Geisel School of Medicine at Dartmouth, Hanover, N.H. (Friedman); National Center for PTSD, U.S. Department of Veterans Affairs (Friedman); Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, N.C. (Williamson); Durham VA Health Care System, Durham, N.C. (Williamson); Department of Neurology, Johns Hopkins School of Medicine, Baltimore (Hyde).
Traumatic Stress Brain Research GroupLieber Institute for Brain Development, Baltimore (Jaffe, Tao, Page, Maynard, Pattie, Nguyen, Deep-Soboslay, Bharadwaj, Shin, Hyde, Martinowich, Kleinman); Department of Neuroscience (Jaffe, Martinowich), Department of Genetic Medicine, McKusick-Nathans Institute of Genetic Medicine (Jaffe), and Department of Psychiatry and Behavioral Sciences (Jaffe, Hyde, Martinowich, Kleinman), Johns Hopkins University School of Medicine, Baltimore; Center for Computational Biology, Johns Hopkins University, Baltimore (Jaffe); Department of Biostatistics and Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Jaffe); Department of Psychiatry and Behavioral Sciences, Texas A&M College of Medicine, Bryan, Tex., Department of Veterans Affairs, VISN 17 Center of Excellence for Research on Returning War Veterans, Waco, Tex., Central Texas Veterans Health Care System, Temple, Tex., and Baylor Scott & White Psychiatry, Temple, Tex. (Young); Department of Psychiatry, Geisel School of Medicine at Dartmouth, Hanover, N.H. (Friedman); National Center for PTSD, U.S. Department of Veterans Affairs (Friedman); Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, N.C. (Williamson); Durham VA Health Care System, Durham, N.C. (Williamson); Department of Neurology, Johns Hopkins School of Medicine, Baltimore (Hyde).
Joo Heon ShinLieber Institute for Brain Development, Baltimore (Jaffe, Tao, Page, Maynard, Pattie, Nguyen, Deep-Soboslay, Bharadwaj, Shin, Hyde, Martinowich, Kleinman); Department of Neuroscience (Jaffe, Martinowich), Department of Genetic Medicine, McKusick-Nathans Institute of Genetic Medicine (Jaffe), and Department of Psychiatry and Behavioral Sciences (Jaffe, Hyde, Martinowich, Kleinman), Johns Hopkins University School of Medicine, Baltimore; Center for Computational Biology, Johns Hopkins University, Baltimore (Jaffe); Department of Biostatistics and Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Jaffe); Department of Psychiatry and Behavioral Sciences, Texas A&M College of Medicine, Bryan, Tex., Department of Veterans Affairs, VISN 17 Center of Excellence for Research on Returning War Veterans, Waco, Tex., Central Texas Veterans Health Care System, Temple, Tex., and Baylor Scott & White Psychiatry, Temple, Tex. (Young); Department of Psychiatry, Geisel School of Medicine at Dartmouth, Hanover, N.H. (Friedman); National Center for PTSD, U.S. Department of Veterans Affairs (Friedman); Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, N.C. (Williamson); Durham VA Health Care System, Durham, N.C. (Williamson); Department of Neurology, Johns Hopkins School of Medicine, Baltimore (Hyde).
Thomas M HydeLieber Institute for Brain Development, Baltimore (Jaffe, Tao, Page, Maynard, Pattie, Nguyen, Deep-Soboslay, Bharadwaj, Shin, Hyde, Martinowich, Kleinman); Department of Neuroscience (Jaffe, Martinowich), Department of Genetic Medicine, McKusick-Nathans Institute of Genetic Medicine (Jaffe), and Department of Psychiatry and Behavioral Sciences (Jaffe, Hyde, Martinowich, Kleinman), Johns Hopkins University School of Medicine, Baltimore; Center for Computational Biology, Johns Hopkins University, Baltimore (Jaffe); Department of Biostatistics and Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Jaffe); Department of Psychiatry and Behavioral Sciences, Texas A&M College of Medicine, Bryan, Tex., Department of Veterans Affairs, VISN 17 Center of Excellence for Research on Returning War Veterans, Waco, Tex., Central Texas Veterans Health Care System, Temple, Tex., and Baylor Scott & White Psychiatry, Temple, Tex. (Young); Department of Psychiatry, Geisel School of Medicine at Dartmouth, Hanover, N.H. (Friedman); National Center for PTSD, U.S. Department of Veterans Affairs (Friedman); Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, N.C. (Williamson); Durham VA Health Care System, Durham, N.C. (Williamson); Department of Neurology, Johns Hopkins School of Medicine, Baltimore (Hyde).
Keri MartinowichLieber Institute for Brain Development, Baltimore (Jaffe, Tao, Page, Maynard, Pattie, Nguyen, Deep-Soboslay, Bharadwaj, Shin, Hyde, Martinowich, Kleinman); Department of Neuroscience (Jaffe, Martinowich), Department of Genetic Medicine, McKusick-Nathans Institute of Genetic Medicine (Jaffe), and Department of Psychiatry and Behavioral Sciences (Jaffe, Hyde, Martinowich, Kleinman), Johns Hopkins University School of Medicine, Baltimore; Center for Computational Biology, Johns Hopkins University, Baltimore (Jaffe); Department of Biostatistics and Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Jaffe); Department of Psychiatry and Behavioral Sciences, Texas A&M College of Medicine, Bryan, Tex., Department of Veterans Affairs, VISN 17 Center of Excellence for Research on Returning War Veterans, Waco, Tex., Central Texas Veterans Health Care System, Temple, Tex., and Baylor Scott & White Psychiatry, Temple, Tex. (Young); Department of Psychiatry, Geisel School of Medicine at Dartmouth, Hanover, N.H. (Friedman); National Center for PTSD, U.S. Department of Veterans Affairs (Friedman); Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, N.C. (Williamson); Durham VA Health Care System, Durham, N.C. (Williamson); Department of Neurology, Johns Hopkins School of Medicine, Baltimore (Hyde).
Joel E KleinmanLieber Institute for Brain Development, Baltimore (Jaffe, Tao, Page, Maynard, Pattie, Nguyen, Deep-Soboslay, Bharadwaj, Shin, Hyde, Martinowich, Kleinman); Department of Neuroscience (Jaffe, Martinowich), Department of Genetic Medicine, McKusick-Nathans Institute of Genetic Medicine (Jaffe), and Department of Psychiatry and Behavioral Sciences (Jaffe, Hyde, Martinowich, Kleinman), Johns Hopkins University School of Medicine, Baltimore; Center for Computational Biology, Johns Hopkins University, Baltimore (Jaffe); Department of Biostatistics and Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Jaffe); Department of Psychiatry and Behavioral Sciences, Texas A&M College of Medicine, Bryan, Tex., Department of Veterans Affairs, VISN 17 Center of Excellence for Research on Returning War Veterans, Waco, Tex., Central Texas Veterans Health Care System, Temple, Tex., and Baylor Scott & White Psychiatry, Temple, Tex. (Young); Department of Psychiatry, Geisel School of Medicine at Dartmouth, Hanover, N.H. (Friedman); National Center for PTSD, U.S. Department of Veterans Affairs (Friedman); Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, N.C. (Williamson); Durham VA Health Care System, Durham, N.C. (Williamson); Department of Neurology, Johns Hopkins School of Medicine, Baltimore (Hyde).
Allen Institute for Brain Science · US
Funding
Regulation of neural activity in fear circuits by promoter IV derived BDNFR01MH105592 · NIMH · LIEBER INSTITUTE, INC. · PI MARTINOWICH, KERI · 2015 to 2024
$5.6MRegistration of spatial gene expression in key nodes of reward-related circuitry in the human brainR01DA053581 · NIDA · LIEBER INSTITUTE, INC. · PI MARTINOWICH, KERI · 2021 to 2025
$3.7MNIMH NIH HHS R01 MH105592
Abstract
objectivePosttraumatic stress disorder (PTSD) is a debilitating neuropsychiatric disease that is highly comorbid with major depressive disorder (MDD) and bipolar disorder. The overlap in symptoms is hypothesized to stem from partially shared genetics and underlying neurobiological mechanisms. To delineate conservation between transcriptional patterns across PTSD and MDD, the authors examined gene expression in the human cortex and amygdala in these disorders.
methodsRNA sequencing was performed in the postmortem brain of two prefrontal cortex regions and two amygdala regions from donors diagnosed with PTSD (N=107) or MDD (N=109) as well as from neurotypical donors (N=109).
resultsThe authors identified a limited number of differentially expressed genes (DEGs) specific to PTSD, with nearly all mapping to cortical versus amygdala regions. PTSD-specific DEGs were enriched in gene sets associated with downregulated immune-related pathways and microglia as well as with subpopulations of GABAergic inhibitory neurons. While a greater number of DEGs associated with MDD were identified, most overlapped with PTSD, and only a few were MDD specific. The authors used weighted gene coexpression network analysis as an orthogonal approach to confirm the observed cellular and molecular associations.
conclusionsThese findings provide supporting evidence for involvement of decreased immune signaling and neuroinflammation in MDD and PTSD pathophysiology, and extend evidence that GABAergic neurons have functional significance in PTSD.
Indexed as
Major Depressive DisorderStress Disorders, Post-TraumaticAmygdalaHumansPrefrontal CortexTranscriptomeDepressive DisordersHuman Postmortem TissueMajor Depressive DisorderPosttraumatic Stress Disorder (PTSD)RNA Sequencing
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