Evidence map›Paper›PMID 35791358›Full record

ArticleOpen forum infectious diseases2022

Outcomes of B-Cell-Depleted Patients With Coronavirus Disease 2019 Treated With Antispike Monoclonal Antibodies.

Zachary A Yetmar, Ryan B Khodadadi, Maria Teresa Seville, Lisa Brumble, John C O'Horo, Ravindra Ganesh, Raymund R Razonable

Abstract read
In one paragraph

Article in Open forum infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. COVID-19 in patients with B cell immune deficiency.Journal of immunological methods · 2022
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zachary A YetmarDivision of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, USA.ORCID https://orcid.org/0000-0003-2098-2868
Ryan B KhodadadiDivision of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, USA.ORCID https://orcid.org/0000-0003-1903-6700
Maria Teresa SevilleDivision of Infectious Diseases, Mayo Clinic, Scottsdale, Arizona, USA.
Lisa BrumbleDivision of Infectious Diseases, Mayo Clinic, Jacksonville, Florida, USA.ORCID https://orcid.org/0000-0001-5761-7309
John C O'HoroDivision of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, USA.ORCID https://orcid.org/0000-0002-0880-4498
Ravindra GaneshDivision of General Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.ORCID https://orcid.org/0000-0002-6877-1712
Raymund R RazonableDivision of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, USA.ORCID https://orcid.org/0000-0001-5248-0227

Funding

Mayo Clinic Center for Clinical and Translational Science (CCaTS UL1 Supplement - Dr. Timothy Curry)UL1TR002377 · NCATS · MAYO CLINIC ROCHESTER · PI VESNA D GAROVIC · 2017 to 2026
$78.4M
NCATS NIH HHS UL1 TR002377
6 · The paper itself

Abstract

Antispike monoclonal antibody treatment of 180 B-cell-depleted patients with mild-to-moderate coronavirus disease 2019 (COVID-19) resulted in good outcomes overall, with only 12.2% progressing to severe disease, 9.4% requiring hospitalization, 0.6% requiring mechanical ventilation, no deaths within 30 days, and 1.8% developing persistent COVID-19. Antispike monoclonal antibodies appear effective in this immunocompromised population.

Indexed as

anti-CD20COVID-19monoclonal antibodyrituximabSARS-CoV-2

Identifiers

PMID35791358
PMCPMC9047222

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.