ArticleOpen forum infectious diseases2022
Longitudinal Analysis of SARS-CoV-2 Vaccine Breakthrough Infections Reveals Limited Infectious Virus Shedding and Restricted Tissue Distribution.
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Article in Open forum infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
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44citing papers in PubMed, 1 pooled it
5.9field-weighted citation impact, top 3% of its field
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Duration of SARS-CoV-2 shedding: A systematic review.Journal of global health · 2024Pooled it
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- In depth sequencing of a serially sampled household cohort reveals the within-host dynamics of Omicron SARS-CoV-2 and rare selection of novel spike variants.PLoS pathogens · 2025Article
- The ratio between SARS-CoV-2 RNA viral load and culturable viral titre differs depending on the stage of infection: a case study of household transmission in an adult male.Access microbiology · 2025Article
- Evolution of SARS-CoV-2 in the murine central nervous system drives viral diversification.Nature microbiology · 2024Article
- Modeling the transmission mitigation impact of testing for infectious diseases.Science advances · 2024Article
- Modeling the Transmission Mitigation Impact of Testing for Infectious Diseases.medRxiv : the preprint server for health sciences · 2024Article
- Within-host evolutionary dynamics and tissue compartmentalization during acute SARS-CoV-2 infection.Journal of virology · 2024Article
- The effectiveness of booster vaccination of inactivated COVID-19 vaccines against susceptibility, infectiousness, and transmission of omicron BA.2 variant: a retrospective cohort study in Shenzhen, China.Frontiers in immunology · 2024Article
- Evaluation of the analytical performance of the 15-minute point-of-care DASH™ SARS-CoV-2 RT-qPCR test.Diagnostic microbiology and infectious disease · 2024Article
- Prior SARS-CoV-2 Infection Enhances Initial mRNA Vaccine Response with a Lower Impact on Long-Term Immunity.ImmunoHorizons · 2023Article
- Article
- Making waves: Integrating wastewater surveillance with dynamic modeling to track and predict viral outbreaks.Water research · 2023Article
- Daily SARS-CoV-2 Nasal Antigen Tests Miss Infected and Presumably Infectious People Due to Viral Load Differences among Specimen Types.Microbiology spectrum · 2023Article
- Article
- Extreme differences in SARS-CoV-2 viral loads among respiratory specimen types during presumed pre-infectious and infectious periods.PNAS nexus · 2023Article
- SARS-CoV-2 viral load and shedding kinetics.Nature reviews. Microbiology · 2023Review
- Ascertainment rate of SARS-CoV-2 infections from healthcare and community testing in the UK.Journal of theoretical biology · 2023Article
- Omicron variant: assessing the duration of viral shedding and its implications.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2023Article
Corrections and comments
- Update of
Authors and funding
43 authors at 5 institutions in 1 country.
Ruian KeT-6, Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, USA.ORCID https://orcid.org/0000-0001-5307-8934
Pamela P MartinezDepartment of Microbiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.ORCID https://orcid.org/0000-0002-3607-0938
Rebecca L SmithCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Laura L GibsonDivision of Infectious Diseases and Immunology, Departments of Medicine and Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Chad J AchenbachDivision of Infectious Diseases and Immunology, Departments of Medicine and Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Sally McFallCenter for Innovation in Point-of-Care Technologies for HIV/AIDS at Northwestern University, Evanston, Illinois, USA.
Chao QiDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Joshua JacobInstitute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Etienne DembeleInstitute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Camille BundyInstitute for Sexual and Gender Minority Health and Wellbeing, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Lacy M SimonsInstitute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Egon A OzerInstitute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Judd F HultquistInstitute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Ramon Lorenzo-RedondoInstitute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Anita K OpdyckeDepartment of Health Service, Northwestern University, Evanston, Illinois, USA.
Claudia HawkinsInstitute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Robert L MurphyInstitute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Agha MirzaDivision of Infectious Diseases, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Madison ConteDivision of Infectious Diseases, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Nicholas GallagherDivision of Medical Microbiology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Chun Huai LuoDivision of Medical Microbiology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Junko JarrettDivision of Medical Microbiology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Abigail ConteW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Ruifeng ZhouW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Mireille FarjoDepartment of Microbiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Gloria RendonHigh-Performance Biological Computing at the Roy J. Carver Biotechnology Center, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Christopher J FieldsHigh-Performance Biological Computing at the Roy J. Carver Biotechnology Center, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.ORCID https://orcid.org/0000-0002-7749-5844
Leyi WangVeterinary Diagnostic Laboratory, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Richard FredricksonVeterinary Diagnostic Laboratory, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Melinda E BaughmanCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Karen K ChiuCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Hannah ChoiCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Kevin R ScardinaCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Alyssa N OwensCenter for Clinical and Translational Research, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
John BroachDivision of Infectious Diseases and Immunology, Departments of Medicine and Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Bruce BartonDivision of Biostatistics and Health Services Research, University of Massachusetts Medical School, Worcester, Massachusetts, USA.ORCID https://orcid.org/0000-0001-7878-8895
Peter LazarDivision of Biostatistics and Health Services Research, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Matthew L RobinsonDivision of Infectious Diseases and Immunology, Departments of Medicine and Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Heba H MostafaDivision of Medical Microbiology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Yukari C ManabeDivision of Infectious Diseases and Immunology, Departments of Medicine and Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Andrew PekoszW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0003-3248-1761
David D McManusDivision of Infectious Diseases and Immunology, Departments of Medicine and Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Christopher B BrookeDepartment of Microbiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.ORCID https://orcid.org/0000-0002-6815-1193
Northwestern University · USUniversity of Illinois Urbana-Champaign · USJohns Hopkins University · USUniversity of Massachusetts Chan Medical School · USLos Alamos National Laboratory · US
Funding
The Center for Advancing Point of Care in Heart, Lung, Blood and Sleep DiseasesU54HL143541 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BRYAN O BUCHHOLZ, Nathaniel Scott Hafer · 2018 to 2026
$141.0MNorthwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8MUniversity of Massachusetts Center for Clinical Science and Translational SupplementUL1TR001453 · NCATS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LUZURIAGA, KATHERINE F · 2015 to 2024
$39.0MThe Center for Innovation in Point-of-Care Technologies for HIV/AIDS atNorthwestern University (C-THAN) Supplemental RequestU54EB027049 · NIBIB · NORTHWESTERN UNIVERSITY · PI Kara M Palamountain · 2018 to 2026
$24.0MModeling the HIV latent reservoir, latency reversal and immunotherapeutics for HIV cureR01AI152703 · NIAID · TRIAD NATIONAL SECURITY, LLC · PI KE, RUIAN · 2020 to 2024
$3.0MHigh resolution profiling and computational modeling of influenza virus-immune dynamics during natural infectionU01AI186993 · NIAID · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Christopher Byron Brooke, Ruian Ke · 2025 to 2026
$2.7MAssessing the Risk of SARS-CoV-2 Remdesivir ResistanceR21AI163912 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HULTQUIST, JUDD F · 2021 to 2022
$440kNCATS NIH HHS UL1 TR001422NCATS NIH HHS UL1 TR001453NHLBI NIH HHS U54 HL143541NIAID NIH HHS R01 AI152703NIAID NIH HHS R21 AI163912NIAID NIH HHS U01 AI186993NIBIB NIH HHS U54 EB027049
Abstract
Background: The global effort to vaccinate people against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during an ongoing pandemic has raised questions about how vaccine breakthrough infections compare with infections in immunologically naive individuals and the potential for vaccinated individuals to transmit the virus. Methods: We examined viral dynamics and infectious virus shedding through daily longitudinal sampling in 23 adults infected with SARS-CoV-2 at varying stages of vaccination, including 6 fully vaccinated individuals. Results: The durations of both infectious virus shedding and symptoms were significantly reduced in vaccinated individuals compared with unvaccinated individuals. We also observed that breakthrough infections are associated with strong tissue compartmentalization and are only detectable in saliva in some cases. Conclusions: Vaccination shortens the duration of time of high transmission potential, minimizes symptom duration, and may restrict tissue dissemination.
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breakthrough infectionsSARS-CoV-2vaccinesviral dynamics
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