Evidence map›Paper›PMID 35791323›Full record

ArticleJournal of experimental pharmacology2022

Filmon Kiflezghi Kiflemariam, Abiel Ghebrehiwet Tewelde, Ali Mahmud Hamid, Bilal Mussa Beshir, Samrawit Negasi Solomon, Tesfu Gonets Eman, Daniel Mebrahtu Abraha, Russom Kahsu, John Issac, Jeevan Jyoti Kaushik

Open access · goldAbstract read
In one paragraph

Article in Journal of experimental pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Antioxidant and Anticoagulant Screening ofCardiovascular & hematological disorders drug targets · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Filmon Kiflezghi KiflemariamDepartment of Clinical Laboratory Sciences, Asmara College of Health Sciences, Asmara, Eritrea.ORCID 0000-0001-6102-5357
Abiel Ghebrehiwet TeweldeDepartment of Clinical Laboratory Sciences, Asmara College of Health Sciences, Asmara, Eritrea.
Ali Mahmud HamidDepartment of Clinical Laboratory Sciences, Asmara College of Health Sciences, Asmara, Eritrea.
Bilal Mussa BeshirDepartment of Clinical Laboratory Sciences, Asmara College of Health Sciences, Asmara, Eritrea.
Samrawit Negasi SolomonDepartment of Clinical Laboratory Sciences, Asmara College of Health Sciences, Asmara, Eritrea.
Tesfu Gonets EmanDepartment of Clinical Laboratory Sciences, Asmara College of Health Sciences, Asmara, Eritrea.
Daniel Mebrahtu AbrahaDepartment of Clinical Laboratory Sciences, Asmara College of Health Sciences, Asmara, Eritrea.
Russom KahsuDepartment of Clinical Laboratory Sciences, Asmara College of Health Sciences, Asmara, Eritrea.
John IssacDepartment of Clinical Laboratory Sciences, Asmara College of Health Sciences, Asmara, Eritrea.
Jeevan Jyoti KaushikDepartment of Clinical Laboratory Sciences, Asmara College of Health Sciences, Asmara, Eritrea.
University of Asmara · ER

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Currently, cardiovascular disorders are the primary cause of mortality in the world and constitute a serious medical problem. Blood coagulation is an essential process to prevent excessive blood loss through injured blood vessels; however, abnormal blood clotting in the blood vessels can result in fatal cardiovascular disorders. This study investigated the in vitro anticoagulant activity of Methods: The plant leaves were extracted by a decoction method and were further fractionated by a liquid-liquid partition with a solvent of crescent polarity. The in vitro anticoagulant activity of the plant extract and its fractions was assessed by PT and APTT assays, while the membrane stabilizing activity was determined through hypotonic induced hemolysis. Results: The crude aqueous leaf extract of Conclusion: The crude extract and its aqueous residue fraction showed a potent in vitro anticoagulant and membrane stabilizing activity, which shows the potential of the plant's leaves as a new source of bioactive molecules for coagulation-related disorders.

Indexed as

anticoagulantAPTTblood coagulationfractionationin vitromedicinal plantMeriandra diantheraprothrombin time

Identifiers

PMID35791323
PMCPMC9250791
OpenAlexW4283706483

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.