Evidence map›Paper›PMID 35790773›Full record

ArticleNature communications2022

Atypical sideways recognition of CD1a by autoreactive γδ T cell receptors.

Marcin Wegrecki, Tonatiuh A Ocampo, Sachith D Gunasinghe, Anouk von Borstel, Shin Yi Tin, Josephine F Reijneveld, Thinh-Phat Cao, Benjamin S Gully, Jérôme Le Nours, D Branch Moody and 2 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 38 citations in OpenAlex.

  1. γδ T cells in colorectal and liver cancer.Nature reviews. Gastroenterology & hepatology · 2026
    Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Three-Dimensional Modeling ofAntibodies (Basel, Switzerland) · 2025
    Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Cancer immunotherapy by γδ T cells.Science (New York, N.Y.) · 2024
    Review
  15. Article
  16. The Evolving Portrait of γδ TCR Recognition Determinants.Journal of immunology (Baltimore, Md. : 1950) · 2024
    Review
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 5 countries.

Marcin WegreckiInfection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.ORCID 0000-0002-3275-9850
Tonatiuh A OcampoDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, US.
Sachith D GunasingheInfection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.ORCID 0000-0003-3794-3005
Anouk von BorstelInfection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.ORCID 0000-0002-3605-7936
Shin Yi TinInfection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Josephine F ReijneveldDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, US.ORCID 0000-0001-8695-964X
Thinh-Phat CaoInfection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.ORCID 0000-0001-9387-5460
Benjamin S GullyInfection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Jérôme Le NoursInfection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
D Branch MoodyDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, US. bmoody@bwh.harvard.edu.ORCID 0000-0003-2306-3058
Ildiko Van RhijnDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, US. I.vanRhijn@uu.nl.ORCID 0000-0002-1446-5701
Jamie RossjohnInfection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia. Jamie.rossjohn@monash.edu.ORCID 0000-0002-2020-7522
Australian Regenerative Medicine Institute · AUBrigham and Women's Hospital · USDiscovery Institute · US

Funding

T cell response to CDI-restricted lipids in tuberculosisR01AI049313 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI MOODY, DAVID BRANCH · 2001 to 2025
$10.6M
CD1 Presentation of Self Lipids to Human T CellsR01AR048632 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI MOODY, DAVID BRANCH · 2002 to 2024
$9.4M
CD1 autoreactive T cells in human inflammatory skin diseaseR37AR048632 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI DAVID Branch MOODY · 2025 to 2026
$1.1M
NIAID NIH HHS R01 AI049313NIAMS NIH HHS R01 AR048632NIAMS NIH HHS R37 AR048632Wellcome Trust
6 · The paper itself

Abstract

CD1a is a monomorphic antigen-presenting molecule on dendritic cells that presents lipids to αβ T cells. Whether CD1a represents a ligand for other immune receptors remains unknown. Here we use CD1a tetramers to show that CD1a is a ligand for Vδ1

Indexed as

Receptors, Antigen, T-Cell, gamma-deltaT-LymphocytesAntigensLigandsLipidsAntigensLigandsLipidsReceptors, Antigen, T-Cell, gamma-delta

Identifiers

PMID35790773
PMCPMC9256601
OpenAlexW4283814834

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.