ArticleNature communications2022
Vibrio cholerae O139 genomes provide a clue to why it may have failed to usher in the eighth cholera pandemic.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 24 citations in OpenAlex.
- Hospital wastewater-based surveillance as an early-warning system for toxigenicEmerging microbes & infections · 2026Article
- The role of cytochrome oxidases in bacterial virulence.Infection and immunity · 2026Review
- A decade of antimicrobial resistance inMicrobiology spectrum · 2026Article
- Public health surveillance ofJournal of medical microbiology · 2026Article
- Population structure and phylogenetic analysis of Vibrio cholerae non-O1/O139 by whole genome sequencing.PloS one · 2026Article
- Genome-wide investigation of outbreak-associatedFrontiers in microbiology · 2026Article
- Genomic characterization of clinical and environmentalFrontiers in microbiology · 2026Article
- Detection of toxigenicIDCases · 2026Article
- Genomic analysis and antimicrobial resistance ofMicrobial genomics · 2025Article
- Genomic Characteristics and Antibiotic Resistance Evolution of Vibrio cholerae O139 - Anhui Province, China, 2013-2024.China CDC weekly · 2025Article
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- Genomic evolution and rearrangement of CTX-Φ prophage elements inEmerging microbes & infections · 2024Article
- Surveillance of travel-associated isolates elucidates the diversity of non-pandemicMicrobial genomics · 2024Article
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- Cholera rages in Africa and the Middle East: A narrative review on challenges and solutions.Health science reports · 2024Review
- Genomic and functional insights into antibiotic resistance genesMicrobiology (Reading, England) · 2024Article
- Comparison of O-specific polysaccharide responses in patients following infection withmSphere · 2023Article
- Understanding antimicrobial resistance to manage cholera.Nature microbiology · 2023Article
- Antimicrobial resistance heterogeneity among multidrug-resistant Gram-negative pathogens: Phenotypic, genotypic, and proteomic analysis.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
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Authors and funding
18 authors at 9 institutions in 4 countries.
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Abstract
Cholera is a life-threatening infectious disease that remains an important public health issue in several low and middle-income countries. In 1992, a newly identified O139 Vibrio cholerae temporarily displaced the O1 serogroup. No study has been able to answer why the potential eighth cholera pandemic (8CP) causing V. cholerae O139 emerged so successfully and then died out. We conducted a genomic study, including 330 O139 isolates, covering emergence of the serogroup in 1992 through to 2015. We noted two key genomic evolutionary changes that may have been responsible for the disappearance of genetically distinct but temporally overlapping waves (A-C) of O139. Firstly, as the waves progressed, a switch from a homogenous toxin genotype in wave-A to heterogeneous genotypes. Secondly, a gradual loss of antimicrobial resistance (AMR) with the progression of waves. We hypothesize that these two changes contributed to the eventual epidemiological decline of O139.
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