Evidence map›Paper›PMID 35790748›Full record

ArticleLight, science & applications2022

Quantitative phase imaging through an ultra-thin lensless fiber endoscope.

Jiawei Sun, Jiachen Wu, Song Wu, Ruchi Goswami, Salvatore Girardo, Liangcai Cao, Jochen Guck, Nektarios Koukourakis, Juergen W Czarske

Open access · goldAbstract read
In one paragraph

Article in Light, science & applications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
13.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 97 citations in OpenAlex.

  1. Article
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  8. Review
  9. Quantitative phase imaging endoscopy with a metalens.Light, science & applications · 2024
    Article
  10. Review
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  19. Light People: Professor Liangcai Cao.Light, science & applications · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Jiawei SunLaboratory of Measurement and Sensor System Technique (MST), TU Dresden, Helmholtzstrasse 18, 01069, Dresden, Germany. jiawei.sun@tu-dresden.de.ORCID http://orcid.org/0000-0001-8663-1556
Jiachen WuLaboratory of Measurement and Sensor System Technique (MST), TU Dresden, Helmholtzstrasse 18, 01069, Dresden, Germany.
Song WuInstitute for Integrative Nanosciences, IFW Dresden, Helmholtzstraße 20, 01069, Dresden, Germany.
Ruchi GoswamiMax Planck Institute for the Science of Light & Max-Planck-Zentrum für Physik und Medizin, 91058, Erlangen, Germany.ORCID http://orcid.org/0000-0001-9724-2898
Salvatore GirardoMax Planck Institute for the Science of Light & Max-Planck-Zentrum für Physik und Medizin, 91058, Erlangen, Germany.
Liangcai CaoState Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instruments, Tsinghua University, 100084, Beijing, China.ORCID http://orcid.org/0000-0002-8099-2948
Jochen GuckMax Planck Institute for the Science of Light & Max-Planck-Zentrum für Physik und Medizin, 91058, Erlangen, Germany.
Nektarios KoukourakisLaboratory of Measurement and Sensor System Technique (MST), TU Dresden, Helmholtzstrasse 18, 01069, Dresden, Germany. nektarios.koukourakis@tu-dresden.de.
Juergen W CzarskeLaboratory of Measurement and Sensor System Technique (MST), TU Dresden, Helmholtzstrasse 18, 01069, Dresden, Germany. juergen.czarske@tu-dresden.de.ORCID http://orcid.org/0000-0001-7280-0523
Center for Systems Biology Dresden · DEMax Planck Institute for the Science of Light · DELeibniz Institute for Solid State and Materials Research · DETechnische Universität Dresden · DETsinghua University · CN

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) CZ55/40-1EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020) 953121Tsinghua University (THU) 2020023
6 · The paper itself

Abstract

Quantitative phase imaging (QPI) is a label-free technique providing both morphology and quantitative biophysical information in biomedicine. However, applying such a powerful technique to in vivo pathological diagnosis remains challenging. Multi-core fiber bundles (MCFs) enable ultra-thin probes for in vivo imaging, but current MCF imaging techniques are limited to amplitude imaging modalities. We demonstrate a computational lensless microendoscope that uses an ultra-thin bare MCF to perform quantitative phase imaging with microscale lateral resolution and nanoscale axial sensitivity of the optical path length. The incident complex light field at the measurement side is precisely reconstructed from the far-field speckle pattern at the detection side, enabling digital refocusing in a multi-layer sample without any mechanical movement. The accuracy of the quantitative phase reconstruction is validated by imaging the phase target and hydrogel beads through the MCF. With the proposed imaging modality, three-dimensional imaging of human cancer cells is achieved through the ultra-thin fiber endoscope, promising widespread clinical applications.

Identifiers

PMID35790748
PMCPMC9255502
OpenAlexW4200634865

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.