ArticleInternational ophthalmology2022
Microvascular assessment of macula, choroid, and optic disk in children with unilateral amblyopia using OCT angiography.
Article in International ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 10 citations in OpenAlex.
- Superficial Retinal Vascular Network Morphology and Sectoral RNFL Thickness in Children with a History of Bilateral Congenital Cataract Surgery: An Exploratory OCT/OCTA Study.Journal of clinical medicine · 2026Article
- Structural and microvascular changes in anisometropic amblyopia: a comparative analysis of swept-source OCTA.BMC ophthalmology · 2026Article
- Article
- 3D choroidal vascularity index in hyperopic amblyopic eyes of preschool children: a case-control study using SS-OCTA.International journal of ophthalmology · 2026Article
- Macular and optic disc vascular densities measured by optical coherence tomography angiography in pediatric patients with different amblyopia types.BMC ophthalmology · 2025Article
- Choroidal vascular characteristics in anisometropic amblyopia: a comparative analysis.BMC ophthalmology · 2025Article
- Reduced Retinal Vascular Density and Skeleton Length in Amblyopia.Translational vision science & technology · 2024Observational
- Choroid vascular changes in hyperopic anisometropia amblyopia using SS-OCTA.BMC ophthalmology · 2023Article
- Assessment of choroidal vascularity and choriocapillaris blood perfusion in Chinese preschool-age anisometropic hyperopic amblyopia children.Frontiers in pediatrics · 2022Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo investigate the microvascular changes of macula, choroid, and optic disk in children with unilateral amblyopia.
methodsThis prospective cross-sectional study involved 39 unilateral amblyopic children and 39 age- and sex-matched heathy participants who served as control. Vessel densities of the superficial and deep capillary plexuses (SCP and DCP), foveal avascular zone (FAZ) area, macular thickness, optic disk vessel density, retinal nerve fiber layer (RNFL) thickness, choriocapillaris vessel density, and subfoveal choroidal thickness were evaluated by OCT angiography (OCTA). Meanwhile, the correlations of microvascular perfusion and structural changes of macula, choroid, and optic disk were analyzed.
resultsThe vessel density of SCP and DCP in the whole macula in the amblyopic group was significantly lower than that in the control group after adjusting for age, axial length, and spherical equivalents (all P < 0.05). FAZ area, macular thickness, RNFL thickness, and the optic disk vessel density were not statistically different between the amblyopic group and the control group (all P > 0.05). Subfoveal choroidal thickness of amblyopic eyes was significantly higher than that of control eyes(P = 0.032). Choriocapillaris flow void (FV) in the amblyopic group was greater than that in the control group (P = 0.013). Significant differences were observed between the fellow eyes and the control eyes in choriocapillaris FV and subfoveal choroidal thickness (P = 0.011 and P = 0.042, respectively). Foveal SCP and DCP vessel density in all studied eyes were positively correlated with the whole macular thickness, respectively (r = 0.556 and r = 0.627, respectively, both P < 0.001). Whole SCP and DCP vessel density in the amblyopic eyes were negatively correlated with choriocapillaris FV (r = -0.723, P < 0.001; r = -0.512, P = 0.001, respectively).
conclusionChildren with amblyopic eyes have attenuated macular and choriocapillaris perfusion. There is a need for future studies that will investigate the pathophysiology of amblyopia in children by OCTA.
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