Evidence map›Paper›PMID 35790642›Full record

ArticleEuropean journal of epidemiology2022

Proteomics and Population Biology in the Cardiovascular Health Study (CHS): design of a study with mentored access and active data sharing.

Thomas R Austin, Caitlin P McHugh, Jennifer A Brody, Joshua C Bis, Colleen M Sitlani, Traci M Bartz, Mary L Biggs, Nisha Bansal, Petra Buzkova, Steven A Carr and 28 more

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Article in European journal of epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors.

Thomas R AustinCardiovascular Health Research Unit, University of Washington, Seattle, WA, USA. austintr@uw.edu.
Caitlin P McHughAlzheimer's Disease Data Initiative, Kirkland, WA, USA.
Jennifer A BrodyCardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.
Joshua C BisCardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.
Colleen M SitlaniCardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.
Traci M BartzCardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.
Mary L BiggsCardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.
Nisha BansalDivision of Nephrology, University of Washington, Seattle, WA, USA.
Petra BuzkovaDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Steven A CarrBroad Institute of MIT and Harvard, Boston, MA, USA.
Christopher R deFilippiInova Heart and Vascular Institute, Falls Church, VA, USA.
Mitchell S V ElkindDepartment of Neurology, Columbia University, New York, NY, USA.
Howard A FinkGeriatric Research Education & Clinical Center, Minneapolis VA Healthcare System, Minneapolis, MN, USA.
James S FloydCardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.
Alison E FohnerCardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.
Robert E GersztenDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Susan R HeckbertCardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.
Daniel H KatzDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Jorge R KizerCardiology Section, San Francisco VA Health Care System, San Francisco, CA, USA.
Rozenn N LemaitreCardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.
W T LongstrethDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Barbara McKnightDepartment of Medicine, University of Washington, Seattle, WA, USA.
Hao MeiDepartment of Data Science, University of Mississippi Medical Center, Jackson, MS, USA.
Kenneth J MukamalBeth Israel Deaconess Medical Center, Boston, MA, USA.
Anne B NewmanDepartment of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Debby NgoBeth Israel Deaconess Medical Center, Boston, MA, USA.
Michelle C OddenDepartment of Epidemiology and Population Health, Stanford University, Stanford, CA, USA.
Ramachandran S VasanDepartment of Epidemiology, School of Public Health, Boston University, Boston, MA, USA.
Ali ShojaieDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Noah SimonDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
George Davey SmithMRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, UK.
Neil M DaviesMRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, UK.
David S SiscovickThe New York Academy of Medicine, New York, NY, USA.
Nona SotoodehniaCardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.
Russell P TracyDepartments of Pathology & Laboratory Medicine, and Biochemistry, Larner College of Medicine, University of Vermont, Burlington, VT, USA.
Kerri L WigginsCardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.
Jie ZhengMRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, UK.
Bruce M PsatyCardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.

Funding

Exceptional Survival: Trajectories to Functional Aging (CHS All Stars)R01AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2004 to 2016
$9.5M
CARDIOVASCULAR HEALTH STUDY (CHS) - TASK AREA C, STUDY CLOSEOUT75N92021D00006 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE · 2021 to 2024
$8.4M
CHS research resources for the cardiovascular health of older adultsU01HL130114 · NHLBI · UNIVERSITY OF WASHINGTON · PI BURKE, GREGORY L, KRONMAL, RICHARD A · 2016 to 2019
$6.6M
Plasma proteomics in CHS and population biologyR01HL144483 · NHLBI · UNIVERSITY OF WASHINGTON · PI DURDA, JON PETER, GERSZTEN, ROBERT E · 2019 to 2022
$6.0M
CHS Events Follow-up StudyU01HL080295 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2005 to 2008
$4.6M
Plasma Proteome and Risk of Alzheimer Dementia and Related Endophenotypes in the Framingham StudyRF1AG063507 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI GERSZTEN, ROBERT E, RAMACHANDRAN, VASAN S · 2019 to 2019
$4.2M
Proteomic Pathway Discovery in Cardiovascular DiseaseR01HL132320 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI GERSZTEN, ROBERT E, RAMACHANDRAN, VASAN S · 2016 to 2019
$3.4M
Role of EIIIA fibronectin in pulmonary fibrosisR01HL085083 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WHITE, ERIC S · 2007 to 2011
$1.9M
Integrated multi-omics approach to identify early protein biomarkers in Alzheimer's disease and cognitive declineK01AG071689 · NIA · UNIVERSITY OF WASHINGTON · PI FOHNER, ALISON ELIZABETH · 2022 to 2025
$488k
CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65 TO 84N01HC085079 · HC · UNIVERSITY OF WASHINGTON · 1988 to 2005
–
CHS-Transition Phase -268055222-268055222N01HC055222 · HC · UNIVERSITY OF WASHINGTON · PI KRONMAL, RICHARD A · 2005 to 2006
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CORONARY HEART DISEASE &STROKE IN THE ELDERLYN01HC085080 · HC · WAKE FOREST UNIVERSITY · PI BURKE, GREGORY L · 1988 to 2000
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Medical Research Council MC_UU_00011/1NHLBI NIH HHS 75N92021D00006NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS HL144483NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS R01 HL132320NHLBI NIH HHS R01HL132320NHLBI NIH HHS R01 HL144483NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01HL080295NHLBI NIH HHS U01 HL130114NHLBI NIH HHS U01HL130114NIA NIH HHS K01 AG071689NIA NIH HHS R01 AG023629NIA NIH HHS R01AG023629NIA NIH HHS RF1 AG063507NIA NIH HHS RF1AG063507Wellcome Trust
6 · The paper itself

Abstract

backgroundIn the last decade, genomic studies have identified and replicated thousands of genetic associations with measures of health and disease and contributed to the understanding of the etiology of a variety of health conditions. Proteins are key biomarkers in clinical medicine and often drug-therapy targets. Like genomics, proteomics can advance our understanding of biology. METHODS AND

resultsIn the setting of the Cardiovascular Health Study (CHS), a cohort study of older adults, an aptamer-based method that has high sensitivity for low-abundance proteins was used to assay 4979 proteins in frozen, stored plasma from 3188 participants (61% women, mean age 74 years). CHS provides active support, including central analysis, for seven phenotype-specific working groups (WGs). Each CHS WG is led by one or two senior investigators and includes 10 to 20 early or mid-career scientists. In this setting of mentored access, the proteomic data and analytic methods are widely shared with the WGs and investigators so that they may evaluate associations between baseline levels of circulating proteins and the incidence of a variety of health outcomes in prospective cohort analyses. We describe the design of CHS, the CHS Proteomics Study, characteristics of participants, quality control measures, and structural characteristics of the data provided to CHS WGs. We additionally highlight plans for validation and replication of novel proteomic associations.

conclusionThe CHS Proteomics Study offers an opportunity for collaborative data sharing to improve our understanding of the etiology of a variety of health conditions in older adults.

Indexed as

Information DisseminationProteomicsBiomarkersCohort StudiesFemaleHumansMaleProspective StudiesBiomarkersCardiovascular DiseaseCohort StudyGenomicsProteomics

Identifiers

PMID35790642
PMCPMC9255954

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.