ArticlePain and therapy2022
Prevalence of and Risk Factors for Prescription Opioid Misuse, Abuse, Diversion and Doctor Shopping in Japan: A Survey Study.
Article in Pain and therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence of opioid misuse in patients with cancer: a systematic review and meta-analysis.British journal of cancer · 2024Pooled it
- Clinical characteristics and treatment resource utilization among patients with substance use disorders: A comparative study of individuals who misuse pharmaceuticals and use illegal drugs.PCN reports : psychiatry and clinical neurosciences · 2025Article
- Opioid use in postoperative pain management of pediatric appendectomy patients in Japan.Journal of anesthesia · 2025Article
- Consensus statement on chronic pain treatment in cancer survivors.Journal of anesthesia · 2025Review
- Article
- Sex differences in comorbid pain and opioid use disorder: A scoping review.British journal of clinical pharmacology · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
introductionOpioid use disorder is a global problem. Although opioid analgesics are prescribed less frequently in Japan than in many other countries, the rate of aberrant prescription opioid-taking behaviors in Japan is unknown.
methodsAn internet survey was conducted to estimate the prevalence of and risk factors for prescription opioid misuse, abuse, diversion and doctor shopping in Japanese subjects with chronic pain who had been prescribed opioid analgesics.
resultsThe proportion of respondents (n = 387) who reported opioid misuse was 45.5% (95% confidence interval [CI]: 40.4-50.6); rates were: 24.6% (95% CI: 20.3-29.2) for abuse; 15.0% (95% CI: 11.6-19.0) for diversion; and 10.6% (95% CI: 7.7-14.1) for doctor shopping. Aberrant prescription opioid-taking behaviors were higher in participants with chronic post-cancer treatment pain (misuse, 64.2%; abuse, 52.2%) or chronic cancer pain (misuse, 57.4%; abuse, 26.2%) than in those with chronic noncancer pain (misuse, 37.8%; abuse, 17.0%). Younger age, male sex, smoking, habitual drinking, diagnosis of psychiatric disease, use of opioids other than tramadol, and use of opioids for chronic post-cancer treatment pain and chronic cancer pain were identified as risk factors for aberrant prescription opioid-taking behaviors.
conclusionEven in Japan, which has not experienced the surge in opioid consumption documented in other countries, aberrant prescription opioid-taking behaviors were observed. When prescribing opioid analgesics, universal precautions should always be taken for both cancer and non-cancer patients.
trial registrationUMIN000041788.
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