Evidence map›Paper›PMID 35790571›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2022

A retrospective, multicenter study on the management of macular holes without residual internal limiting membrane: the refractory macular hole (ReMaHo) study.

Umberto Lorenzi, Joel Mehech, Tommaso Caporossi, Mario R Romano, Rocco De Fazio, Eric Parrat, Frédéric Matonti, Paolo Mora, ReMaHo Study Group

Open access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. Optimal approaches for managing recurrent macular holes: a comprehensive systematic review and meta-analysis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025
    Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 2 countries.

Umberto LorenziOphthalmology Unit, Centre Hospitalier Universitaire Charles-Nicolle, Rouen, France.
Joel MehechOphthalmology Unit, Centre Hospitalier Universitaire Charles-Nicolle, Rouen, France.
Tommaso CaporossiOphthalmology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Mario R RomanoDepartment of Biomedical Science, Humanitas University, Pieve Emanuele, Milan, Italy.
Rocco De FazioOphthalmology Unit, Ospedale Santa Maria della Scaletta, Imola, Italy.
Eric ParratP 1.5 Group, 80, allée des Ormes, 06250, Mougins, France.
Frédéric MatontiP 1.5 Group, 80, allée des Ormes, 06250, Mougins, France.
Paolo MoraOphthalmology Unit, University Hospital of Parma, 43126, Parma, PR, Italy. paolo.mora@unipr.it.ORCID http://orcid.org/0000-0001-7133-8250
ReMaHo Study Group
Hôpital Charles-Nicolle · FRClinique Claude-Bernard · FRDélégation Provence et Corse · FRHumanitas University · ITOspedale Santa Maria · ITUniversità Cattolica del Sacro Cuore · ITUniversity of Parma · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the surgical management, outcomes and prognostic factors of full thickness macular holes without residual internal limiting membrane (NO-ILM FTMHs).

methodsWe performed a multicenter, retrospective study of 116 NO-ILM FTMHs. Human amniotic membrane (hAM) plug, autologous ILM free flap transplantation (AILMT), and autologous retinal graft transplantation (ART) were performed in 58, 48, and 10 patients, respectively. Data were collected before and up to 12 months after surgery. The primary outcomes were hole closure and final best-corrected visual acuity (BCVA).

resultsThe final BCVA (0.78 ± 0.51 logMAR) was significantly better than and correlated with the initial BCVA (p < 0.0001 and p = 0.004, respectively). Hole closure was achieved in 92% of eyes. The minimum FTMH diameter was wider and final BCVA was lower in the ART group than in the other groups (p < 0.003 and p < 0.001, respectively). FTMHs with diameter > 680 μm had a higher closure rate with hAM than with AILMT (p = 0.02).

conclusionsAILMT and hAM were the most frequently performed surgeries with both high closure rate and significant functional improvement. Preoperative BCVA was correlated with final BCVA. The minimum FTMH diameter may guide the treatment choice.

Indexed as

Retinal PerforationsBasement MembraneHumansRetinaRetrospective StudiesTomography, Optical CoherenceVisual AcuityVitrectomyFull thickness macular holeNo internal limiting membranePrognostic variablesReconstructive surgery

Identifiers

PMID35790571
PMCPMC9666308
OpenAlexW4284663199

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.