Evidence map›Paper›PMID 35790428›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2022

[IRE1

X Li, D Yin, M Fan, Y Yang, L Liang, N Feng, X Li, F Guo

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. [Type III secretory protein SINC ofNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

X LiDepartment of Cell Biology and Genetics, Chongqing Medical University, Chongqing 400016, China.
D YinDepartment of Pathology, Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing 100011, China.
M FanDepartment of Cell Biology and Genetics, Chongqing Medical University, Chongqing 400016, China.
Y YangDepartment of Cell Biology and Genetics, Chongqing Medical University, Chongqing 400016, China.
L LiangDepartment of Cell Biology and Genetics, Chongqing Medical University, Chongqing 400016, China.
N FengDepartment of Cell Biology and Genetics, Chongqing Medical University, Chongqing 400016, China.
X LiDepartment of Cell Biology and Genetics, Chongqing Medical University, Chongqing 400016, China.
F GuoDepartment of Cell Biology and Genetics, Chongqing Medical University, Chongqing 400016, China.
Chongqing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore the mechanism by which inositol-requiring enzyme-1

methodsCultured human chondrocytes (C28/I2 cells) were treated with tunicamycin, 4μ8c, rapamycin, or both 4μ8c and rapamycin, and the expressions of endoplasmic reticulum (ER) stress- and autophagy-related proteins were detected with Western blotting. Primary chondrocytes from ERN1 knockout (ERN1 CKO) mice and wild-type mice were examined for ATG5 and ATG7 mRNA expressions, IRE1

resultsTunicamycin treatment significantly up-regulated ER stress-related proteins and LC3 Ⅱ/LC3 Ⅰ ratio and down-regulated the expression of p62 in C28/I2 cells (

conclusionIRE1

Indexed as

ChondrocytesEndoribonucleasesAnimalsAutophagyCalciumEndoplasmic ReticulumHomeostasisInositolMiceMice, KnockoutProtein Serine-Threonine KinasesRNA, MessengerSirolimusTunicamycinCalciumEndoribonucleasesInositolProtein Serine-Threonine KinasesRNA, MessengerSirolimusTunicamycinautophagic fluxcalcium homeostasis endoplasmic reticulum proteincalcium ionschondrocytesIRE1α

Identifiers

PMID35790428
PMCPMC9257368
OpenAlexW4283827887

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.