Evidence map›Paper›PMID 35790424›Full record

ArticleNeurology2022

Longitudinal Dopamine D2 Receptor Changes and Cerebrovascular Health in Aging.

Nina Karalija, Jarkko Johansson, Goran Papenberg, Anders Wåhlin, Alireza Salami, Ylva Köhncke, Andreas M Brandmaier, Micael Andersson, Jan Axelsson, Katrine Riklund and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 38 citations in OpenAlex.

  1. The role of dopamine decline, astrocyte reactivity and cerebral small-vessel disease in cognitive aging.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Article
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  5. Neurotransmitter Systems in Alzheimer's Disease.Current issues in molecular biology · 2026
    Review
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  20. Amphetamine-induced dopamine release in rat: Whole-brain spatiotemporal analysis with [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 4 countries.

Nina KaralijaFrom the Departments of Radiation Sciences, Diagnostic Radiology (N.K., J.J., K.R., L.N.) and Radiation Physics (A.W., J.A.), Department of Applied Physics and Electronics (A.W.), and Umeå Center for Functional Brain Imaging (UFBI) (N.K., J.J., A.W., A.S., M.A., J.A., K.R., L.N.), Umeå University; Aging Research Center (G.P., A.S., L.B.), Karolinska Institutet & Stockholm University; Department of Integrative Medical Biology (A.S., M.A., L.N.), and Wallenberg Center for Molecular Medicine (A.S., L.N.), Umeå University, Sweden; Center for Lifespan Psychology (Y.K., A.M.B., U.L.), Max Planck Institute for Human Development; Max Planck UCL Centre for Computational Psychiatry and Ageing Research (A.M.B., U.L.), Berlin, Germany and London, UK; and Department of Psychology (M.L.), University of Gothenburg, Sweden. nina.karalija@umu.se.
Jarkko JohanssonFrom the Departments of Radiation Sciences, Diagnostic Radiology (N.K., J.J., K.R., L.N.) and Radiation Physics (A.W., J.A.), Department of Applied Physics and Electronics (A.W.), and Umeå Center for Functional Brain Imaging (UFBI) (N.K., J.J., A.W., A.S., M.A., J.A., K.R., L.N.), Umeå University; Aging Research Center (G.P., A.S., L.B.), Karolinska Institutet & Stockholm University; Department of Integrative Medical Biology (A.S., M.A., L.N.), and Wallenberg Center for Molecular Medicine (A.S., L.N.), Umeå University, Sweden; Center for Lifespan Psychology (Y.K., A.M.B., U.L.), Max Planck Institute for Human Development; Max Planck UCL Centre for Computational Psychiatry and Ageing Research (A.M.B., U.L.), Berlin, Germany and London, UK; and Department of Psychology (M.L.), University of Gothenburg, Sweden.
Goran PapenbergFrom the Departments of Radiation Sciences, Diagnostic Radiology (N.K., J.J., K.R., L.N.) and Radiation Physics (A.W., J.A.), Department of Applied Physics and Electronics (A.W.), and Umeå Center for Functional Brain Imaging (UFBI) (N.K., J.J., A.W., A.S., M.A., J.A., K.R., L.N.), Umeå University; Aging Research Center (G.P., A.S., L.B.), Karolinska Institutet & Stockholm University; Department of Integrative Medical Biology (A.S., M.A., L.N.), and Wallenberg Center for Molecular Medicine (A.S., L.N.), Umeå University, Sweden; Center for Lifespan Psychology (Y.K., A.M.B., U.L.), Max Planck Institute for Human Development; Max Planck UCL Centre for Computational Psychiatry and Ageing Research (A.M.B., U.L.), Berlin, Germany and London, UK; and Department of Psychology (M.L.), University of Gothenburg, Sweden.
Anders WåhlinFrom the Departments of Radiation Sciences, Diagnostic Radiology (N.K., J.J., K.R., L.N.) and Radiation Physics (A.W., J.A.), Department of Applied Physics and Electronics (A.W.), and Umeå Center for Functional Brain Imaging (UFBI) (N.K., J.J., A.W., A.S., M.A., J.A., K.R., L.N.), Umeå University; Aging Research Center (G.P., A.S., L.B.), Karolinska Institutet & Stockholm University; Department of Integrative Medical Biology (A.S., M.A., L.N.), and Wallenberg Center for Molecular Medicine (A.S., L.N.), Umeå University, Sweden; Center for Lifespan Psychology (Y.K., A.M.B., U.L.), Max Planck Institute for Human Development; Max Planck UCL Centre for Computational Psychiatry and Ageing Research (A.M.B., U.L.), Berlin, Germany and London, UK; and Department of Psychology (M.L.), University of Gothenburg, Sweden.
Alireza SalamiFrom the Departments of Radiation Sciences, Diagnostic Radiology (N.K., J.J., K.R., L.N.) and Radiation Physics (A.W., J.A.), Department of Applied Physics and Electronics (A.W.), and Umeå Center for Functional Brain Imaging (UFBI) (N.K., J.J., A.W., A.S., M.A., J.A., K.R., L.N.), Umeå University; Aging Research Center (G.P., A.S., L.B.), Karolinska Institutet & Stockholm University; Department of Integrative Medical Biology (A.S., M.A., L.N.), and Wallenberg Center for Molecular Medicine (A.S., L.N.), Umeå University, Sweden; Center for Lifespan Psychology (Y.K., A.M.B., U.L.), Max Planck Institute for Human Development; Max Planck UCL Centre for Computational Psychiatry and Ageing Research (A.M.B., U.L.), Berlin, Germany and London, UK; and Department of Psychology (M.L.), University of Gothenburg, Sweden.
Ylva KöhnckeFrom the Departments of Radiation Sciences, Diagnostic Radiology (N.K., J.J., K.R., L.N.) and Radiation Physics (A.W., J.A.), Department of Applied Physics and Electronics (A.W.), and Umeå Center for Functional Brain Imaging (UFBI) (N.K., J.J., A.W., A.S., M.A., J.A., K.R., L.N.), Umeå University; Aging Research Center (G.P., A.S., L.B.), Karolinska Institutet & Stockholm University; Department of Integrative Medical Biology (A.S., M.A., L.N.), and Wallenberg Center for Molecular Medicine (A.S., L.N.), Umeå University, Sweden; Center for Lifespan Psychology (Y.K., A.M.B., U.L.), Max Planck Institute for Human Development; Max Planck UCL Centre for Computational Psychiatry and Ageing Research (A.M.B., U.L.), Berlin, Germany and London, UK; and Department of Psychology (M.L.), University of Gothenburg, Sweden.
Andreas M BrandmaierFrom the Departments of Radiation Sciences, Diagnostic Radiology (N.K., J.J., K.R., L.N.) and Radiation Physics (A.W., J.A.), Department of Applied Physics and Electronics (A.W.), and Umeå Center for Functional Brain Imaging (UFBI) (N.K., J.J., A.W., A.S., M.A., J.A., K.R., L.N.), Umeå University; Aging Research Center (G.P., A.S., L.B.), Karolinska Institutet & Stockholm University; Department of Integrative Medical Biology (A.S., M.A., L.N.), and Wallenberg Center for Molecular Medicine (A.S., L.N.), Umeå University, Sweden; Center for Lifespan Psychology (Y.K., A.M.B., U.L.), Max Planck Institute for Human Development; Max Planck UCL Centre for Computational Psychiatry and Ageing Research (A.M.B., U.L.), Berlin, Germany and London, UK; and Department of Psychology (M.L.), University of Gothenburg, Sweden.
Micael AnderssonFrom the Departments of Radiation Sciences, Diagnostic Radiology (N.K., J.J., K.R., L.N.) and Radiation Physics (A.W., J.A.), Department of Applied Physics and Electronics (A.W.), and Umeå Center for Functional Brain Imaging (UFBI) (N.K., J.J., A.W., A.S., M.A., J.A., K.R., L.N.), Umeå University; Aging Research Center (G.P., A.S., L.B.), Karolinska Institutet & Stockholm University; Department of Integrative Medical Biology (A.S., M.A., L.N.), and Wallenberg Center for Molecular Medicine (A.S., L.N.), Umeå University, Sweden; Center for Lifespan Psychology (Y.K., A.M.B., U.L.), Max Planck Institute for Human Development; Max Planck UCL Centre for Computational Psychiatry and Ageing Research (A.M.B., U.L.), Berlin, Germany and London, UK; and Department of Psychology (M.L.), University of Gothenburg, Sweden.
Jan AxelssonFrom the Departments of Radiation Sciences, Diagnostic Radiology (N.K., J.J., K.R., L.N.) and Radiation Physics (A.W., J.A.), Department of Applied Physics and Electronics (A.W.), and Umeå Center for Functional Brain Imaging (UFBI) (N.K., J.J., A.W., A.S., M.A., J.A., K.R., L.N.), Umeå University; Aging Research Center (G.P., A.S., L.B.), Karolinska Institutet & Stockholm University; Department of Integrative Medical Biology (A.S., M.A., L.N.), and Wallenberg Center for Molecular Medicine (A.S., L.N.), Umeå University, Sweden; Center for Lifespan Psychology (Y.K., A.M.B., U.L.), Max Planck Institute for Human Development; Max Planck UCL Centre for Computational Psychiatry and Ageing Research (A.M.B., U.L.), Berlin, Germany and London, UK; and Department of Psychology (M.L.), University of Gothenburg, Sweden.
Katrine RiklundFrom the Departments of Radiation Sciences, Diagnostic Radiology (N.K., J.J., K.R., L.N.) and Radiation Physics (A.W., J.A.), Department of Applied Physics and Electronics (A.W.), and Umeå Center for Functional Brain Imaging (UFBI) (N.K., J.J., A.W., A.S., M.A., J.A., K.R., L.N.), Umeå University; Aging Research Center (G.P., A.S., L.B.), Karolinska Institutet & Stockholm University; Department of Integrative Medical Biology (A.S., M.A., L.N.), and Wallenberg Center for Molecular Medicine (A.S., L.N.), Umeå University, Sweden; Center for Lifespan Psychology (Y.K., A.M.B., U.L.), Max Planck Institute for Human Development; Max Planck UCL Centre for Computational Psychiatry and Ageing Research (A.M.B., U.L.), Berlin, Germany and London, UK; and Department of Psychology (M.L.), University of Gothenburg, Sweden.ORCID 0000-0001-5227-8117
Martin LövdénFrom the Departments of Radiation Sciences, Diagnostic Radiology (N.K., J.J., K.R., L.N.) and Radiation Physics (A.W., J.A.), Department of Applied Physics and Electronics (A.W.), and Umeå Center for Functional Brain Imaging (UFBI) (N.K., J.J., A.W., A.S., M.A., J.A., K.R., L.N.), Umeå University; Aging Research Center (G.P., A.S., L.B.), Karolinska Institutet & Stockholm University; Department of Integrative Medical Biology (A.S., M.A., L.N.), and Wallenberg Center for Molecular Medicine (A.S., L.N.), Umeå University, Sweden; Center for Lifespan Psychology (Y.K., A.M.B., U.L.), Max Planck Institute for Human Development; Max Planck UCL Centre for Computational Psychiatry and Ageing Research (A.M.B., U.L.), Berlin, Germany and London, UK; and Department of Psychology (M.L.), University of Gothenburg, Sweden.
Ulman LindenbergerFrom the Departments of Radiation Sciences, Diagnostic Radiology (N.K., J.J., K.R., L.N.) and Radiation Physics (A.W., J.A.), Department of Applied Physics and Electronics (A.W.), and Umeå Center for Functional Brain Imaging (UFBI) (N.K., J.J., A.W., A.S., M.A., J.A., K.R., L.N.), Umeå University; Aging Research Center (G.P., A.S., L.B.), Karolinska Institutet & Stockholm University; Department of Integrative Medical Biology (A.S., M.A., L.N.), and Wallenberg Center for Molecular Medicine (A.S., L.N.), Umeå University, Sweden; Center for Lifespan Psychology (Y.K., A.M.B., U.L.), Max Planck Institute for Human Development; Max Planck UCL Centre for Computational Psychiatry and Ageing Research (A.M.B., U.L.), Berlin, Germany and London, UK; and Department of Psychology (M.L.), University of Gothenburg, Sweden.
Lars BäckmanFrom the Departments of Radiation Sciences, Diagnostic Radiology (N.K., J.J., K.R., L.N.) and Radiation Physics (A.W., J.A.), Department of Applied Physics and Electronics (A.W.), and Umeå Center for Functional Brain Imaging (UFBI) (N.K., J.J., A.W., A.S., M.A., J.A., K.R., L.N.), Umeå University; Aging Research Center (G.P., A.S., L.B.), Karolinska Institutet & Stockholm University; Department of Integrative Medical Biology (A.S., M.A., L.N.), and Wallenberg Center for Molecular Medicine (A.S., L.N.), Umeå University, Sweden; Center for Lifespan Psychology (Y.K., A.M.B., U.L.), Max Planck Institute for Human Development; Max Planck UCL Centre for Computational Psychiatry and Ageing Research (A.M.B., U.L.), Berlin, Germany and London, UK; and Department of Psychology (M.L.), University of Gothenburg, Sweden.
Lars NybergFrom the Departments of Radiation Sciences, Diagnostic Radiology (N.K., J.J., K.R., L.N.) and Radiation Physics (A.W., J.A.), Department of Applied Physics and Electronics (A.W.), and Umeå Center for Functional Brain Imaging (UFBI) (N.K., J.J., A.W., A.S., M.A., J.A., K.R., L.N.), Umeå University; Aging Research Center (G.P., A.S., L.B.), Karolinska Institutet & Stockholm University; Department of Integrative Medical Biology (A.S., M.A., L.N.), and Wallenberg Center for Molecular Medicine (A.S., L.N.), Umeå University, Sweden; Center for Lifespan Psychology (Y.K., A.M.B., U.L.), Max Planck Institute for Human Development; Max Planck UCL Centre for Computational Psychiatry and Ageing Research (A.M.B., U.L.), Berlin, Germany and London, UK; and Department of Psychology (M.L.), University of Gothenburg, Sweden.
Max Planck Institute for Human Development · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesCross-sectional studies suggest marked dopamine (DA) decline in aging, but longitudinal evidence is lacking. The aim of this study was to estimate within-person decline rates for DA D2-like receptors (DRD2) in aging and examine factors that may contribute to individual differences in DRD2 decline rates.

methodsWe investigated 5-year within-person changes in DRD2 availability in a sample of older adults. At both occasions, PET with

resultsLongitudinal analyses of the sample (baseline: n = 181, ages: 64-68 years, 100 men and 81 women; 5-year follow-up: n = 129, 69 men and 60 women) revealed aging-related striatal and extrastriatal DRD2 decline, along with marked individual differences in rates of change. Notably, the magnitude of striatal DRD2 decline was ∼50% of past cross-sectional estimates, suggesting that the DRD2 decline rate has been overestimated in past cross-sectional studies. Significant DRD2 reductions were also observed in select extrastriatal regions, including hippocampus, orbitofrontal cortex (OFC), and anterior cingulate cortex (ACC). Distinct profiles of correlated DRD2 changes were found across several associative regions (ACC, dorsal striatum, and hippocampus) and in the reward circuit (nucleus accumbens and OFC). DRD2 losses in associative regions were associated with white matter lesion progression, whereas DRD2 losses in limbic regions were related to reduced cortical perfusion. DISCUSSION: These findings provide the first longitudinal evidence for individual and region-specific differences of DRD2 decline in older age and support the hypothesis that cerebrovascular factors are linked to age-related dopaminergic decline.

Indexed as

DopamineReceptors, Dopamine D2AgedAgingCross-Sectional StudiesFemaleHumansMaleMiddle AgedPositron-Emission TomographyRacloprideReceptors, Dopamine D3DopamineDRD2 protein, humanRacloprideReceptors, Dopamine D2Receptors, Dopamine D3

Identifiers

PMID35790424
PMCPMC9576296
OpenAlexW4283832958

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.