ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022
Elevated TNF-α Leads to Neural Circuit Instability in the Absence of Interferon Regulatory Factor 8.
Open access · bronzeAbstract read
In one paragraph
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 27 citations in OpenAlex.
- TNF-dependent regulation of synaptic plasticity and neuronal activity: implications for psychiatric disorders.Molecular psychiatry · 2026Review
- Th17 effector cytokines induce shared and distinct microglial and endothelial cell responses in a mouse model for post-streptococcal encephalitis.Nature communications · 2026Article
- TNF-α and IFN-γ impair neural oscillations and induce neurodegeneration by microglial nitric oxide, metabolic and oxidative stress.Journal of neuroinflammation · 2026Article
- Fn14 is an activity-dependent, Bmal1-regulated cytokine receptor that induces rod-like microglia and restricts neuronal activity in vivo.Cell reports · 2026Article
- Th17 effector cytokines induce shared and distinct microglial and endothelial cell responses in post-streptococcal encephalitis.bioRxiv : the preprint server for biology · 2026Article
- TNF-α in traumatic brain injury: a bidirectional effect in regulating neuroimmune and inflammatory responses.Cellular and molecular life sciences : CMLS · 2025Review
- Aging in mice alters regionally enriched striatal astrocytes.Nature communications · 2025Article
- Article
- Single-cell spatial transcriptomics reveals distinct patterns of dysregulation in non-neuronal and neuronal cells induced by the Trem2Molecular psychiatry · 2025Article
- The multiple roles of interferon regulatory factor family in health and disease.Signal transduction and targeted therapy · 2024Review
- Glial Control of Cortical Neuronal Circuit Maturation and Plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- IRF8 as durable architect of the microglial chromatin landscape.Nature immunology · 2024Article
- IRF8 and MAFB drive distinct transcriptional machineries in different resident macrophages of the central nervous system.Communications biology · 2024Article
- The neural and cardiovascular effects of exposure of gram-positive bacterial inflammation in preterm fetal sheep.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- The cytokine receptor Fn14 is a molecular brake on neuronal activity that mediates circadian functionbioRxiv : the preprint server for biology · 2024Article
- Microglia: Activity-dependent regulators of neural circuits.Annals of the New York Academy of Sciences · 2024Review
- Tuning neural circuits and behaviors by microglia in the adult brain.Trends in neurosciences · 2024Review
- The roles of tissue resident macrophages in health and cancer.Experimental hematology & oncology · 2024Review
- Altered neuroepithelial morphogenesis and migration defects in iPSC-derived cerebral organoids and 2D neural stem cells in familial bipolar disorder.Oxford open neuroscience · 2024Article
- Single cell spatial transcriptomics reveals distinct patterns of dysregulation in non-neuronal and neuronal cells induced by theResearch square · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Philip A FeinbergDepartment of Neurobiology, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Chan Medical School, Worcester, Massachusetts 01605.
Shannon C BeckerDepartment of Neurobiology, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Chan Medical School, Worcester, Massachusetts 01605.
Leeyup ChungDepartment of Neurobiology, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Chan Medical School, Worcester, Massachusetts 01605.
Loris FerrariDepartment of Neurobiology, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Chan Medical School, Worcester, Massachusetts 01605.
David StellwagenDepartment of Neurology and Neurosurgery, Centre for Research in Neuroscience, Research Institute of the McGill University Health Center, Montreal, Quebec Canada H3G 1A4.
Christelle AnacletDepartment of Neurobiology, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Chan Medical School, Worcester, Massachusetts 01605.
Violeta Durán-LaforetDepartment of Neurobiology, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Chan Medical School, Worcester, Massachusetts 01605.
Travis E FaustDepartment of Neurobiology, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Chan Medical School, Worcester, Massachusetts 01605.ORCID https://orcid.org/0000-0002-4567-8435
Rachita K SumbriaDepartment of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, California 92618.
Dorothy P SchaferDepartment of Neurobiology, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Chan Medical School, Worcester, Massachusetts 01605 dorothy.schafer@umassmed.edu.
University of Massachusetts Chan Medical School · USChapman University · USMcGill University Health Centre · CA
Funding
Microglia-dependent mechanisms governing neural circuit plasticityR01MH113743 · NIMH · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Dorothy Patricia Schafer · 2017 to 2026
$4.9MUniversity of Massachusetts Center for Clinical and Translational ScienceTL1TR001454 · NCATS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LEWIS, BRIAN C · 2015 to 2024
$3.6MModulation of the liver-brain axis by alcohol and its impact on Alzheimers disease pathologyR01AG072896 · NIA · KECK GRADUATE INST OF APPLIED LIFE SCIS · PI HAN, DERICK S, SUMBRIA, RACHITA · 2020 to 2024
$2.3MHow Do Synaptic Connections Change in Demyelinating Disease?R01NS117533 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SCHAFER, DOROTHY PATRICIA · 2021 to 2025
$2.2MBrainstem circuitry for sleep-wake controlR01NS119597 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI ANACLET, CHRISTELLE · 2021 to 2025
$2.0MA Brain Penetrating Bi-functional Transferrin Receptor Antibody-TNF-alpha Decoy Receptor Fusion Protein for Alzheimer's DiseaseR01AG062840 · NIA · KECK GRADUATE INST OF APPLIED LIFE SCIS · PI SUMBRIA, RACHITA · 2019 to 2024
$1.9MDissecting the impact of senescence on microglia function and neurodegenerationRF1AG068281 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SCHAFER, DOROTHY PATRICIA, ZHANG, HONG · 2020 to 2020
$1.7MMedullary Circuitry Regulating Slow-Wave-SleepR00MH103399 · NIMH · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI ANACLET, CHRISTELLE · 2017 to 2019
$742kMedullary Circuitry Regulating Slow-Wave-SleepK99MH103399 · NIMH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI ANACLET, CHRISTELLE · 2014 to 2015
$167kNCATS NIH HHS TL1 TR001454NIA NIH HHS R01 AG062840NIA NIH HHS R01 AG072896NIA NIH HHS RF1 AG068281NIMH NIH HHS K99 MH103399NIMH NIH HHS R00 MH103399NIMH NIH HHS R01 MH113743NINDS NIH HHS R01 NS117533NINDS NIH HHS R01 NS119597
Abstract
Interferon regulatory factor 8 (IRF8) is a transcription factor necessary for the maturation of microglia, as well as other peripheral immune cells. It also regulates the transition of microglia and other immune cells to a pro-inflammatory phenotype.
Indexed as
Tumor Necrosis Factor-alphaAnimalsFemaleInterferon Regulatory Factor-8Interferon Regulatory FactorsMaleMiceMultiple SclerosisSeizuresInterferon Regulatory Factor-8Interferon Regulatory FactorsTumor Necrosis Factor-alphaIRF8microglianeural-immuneseizuressynapsesTNF alpha
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.