Evidence map›Paper›PMID 35790333›Full record

ArticleBMJ open2022

Acute pain pathways: protocol for a prospective cohort study.

Molly Moore Jeffery, Mitra Ahadpour, Summer Allen, Richardae Araojo, Fernanda Bellolio, Nancy Chang, Laura Ciaccio, Lindsay Emanuel, Jonathan Fillmore, Gregg H Gilbert and 20 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04509115 (Real-World Data to Assess Variation in Opioid Prescribing and Use for Acute Pain in Diverse Populations), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04509115 completednot on this map

Real-World Data to Assess Variation in Opioid Prescribing and Use for Acute Pain in Diverse Populations

TypeobservationalSponsorYale UniversityRan2020 to 2023Enrolled1,709ConditionsOpioid Use, Opioid PrescribingArmsShort-acting opioid prescription for acute pain
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors at 9 institutions in 3 countries.

Molly Moore JefferyEmergency Medicine and Health Care Delivery Research, Mayo Clinic, Rochester, Minnesota, USA jeffery.molly@mayo.edu.ORCID 0000-0003-3854-6810
Mitra AhadpourCenter for Drug Evaluation and Research, Office of Surveillance and Epidemiology, US Food and Drug Administration, Silver Spring, Maryland, USA.
Summer AllenKnowledge and Evaluation Research Unit; Department of Family Medicine, Mayo Clinic Rochester, Rochester, Minnesota, USA.
Richardae AraojoOffice of the Commissioner, Office of Minority Health and Health Equity, US Food and Drug Administration, Silver Spring, Maryland, USA.
Fernanda BellolioEmergency Medicine and Health Care Delivery Research, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0002-1632-4750
Nancy ChangCenter for Drug Evaluation and Research, Office of Translational Sciences, US Food and Drug Administration, Silver Spring, Maryland, USA.
Laura CiaccioDivision of Population Health and Genomics, University of Dundee School of Medicine, Dundee, UK.
Lindsay EmanuelDivision of Health Care Delivery Research, Kern Center for the Science of Health Care Delivery, Mayo Clinic Rochester, Rochester, Minnesota, USA.
Jonathan FillmoreDepartment of Surgery, Mayo Clinic Division of Oral and Maxillofacial Surgery, Rochester, Minnesota, USA.
Gregg H GilbertDepartment of Clinical and Community Sciences, School of Dentistry, The University of Alabama at Birmingham School of Dentistry, Birmingham, Alabama, USA.
Patricia KoussisCenter for Drug Evaluation and Research, Office of Translational Sciences, US Food and Drug Administration, Silver Spring, Maryland, USA.
Christine LeeOffice of the Commissioner, Office of Minority Health and Health Equity, US Food and Drug Administration, Silver Spring, Maryland, USA.
Heather LipkindDepartment of Obstetrics, Gynecology, & Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut, USA.
Celeste MallamaCenter for Drug Evaluation and Research, Office of Surveillance and Epidemiology, US Food and Drug Administration, Silver Spring, Maryland, USA.
Tamra MeyerCenter for Drug Evaluation and Research, Office of Surveillance and Epidemiology, US Food and Drug Administration, Silver Spring, Maryland, USA.
Megan MoncurCenter for Drug Evaluation and Research, Office of New Drugs, US Food and Drug Administration, Silver Spring, Maryland, USA.
Teryl NuckolsDivision of General Internal Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Michael A PacanowskiCenter for Drug Evaluation and Research, Office of Translational Sciences, US Food and Drug Administration, Silver Spring, Maryland, USA.
David B PageDepartment of Emergency Medicine, Department of Medicine, Division of Pulmonary, Allergy & Critical Care Medicine, The University of Alabama, Birmingham, Alabama, USA.
Elektra PapadopoulosCenter for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA.
Jessica D RitchieCenter for Outcomes Research and Evaluation, Yale University Center for Outcomes Research and Evaluation, New Haven, Connecticut, USA.
Joseph S RossInternal Medicine, Yale University Center for Outcomes Research and Evaluation, New Haven, Connecticut, USA.
Nilay D ShahHealth Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
Mat SoukupCenter for Drug Evaluation and Research, Office of Translational Sciences, US Food and Drug Administration, Silver Spring, Maryland, USA.
Christopher O St ClairCenter for Drug Evaluation and Research, Office of New Drugs, US Food and Drug Administration, Silver Spring, Maryland, USA.
Stephen TamangDepartment of Family Medicine, Monument Health, Rapid City, South Dakota, USA.
Sam TorbatiDepartment of Emergency Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Douglas W WallaceDepartment of Emergency Medicine, Department of Medicine, Division of Pulmonary, Allergy & Critical Care Medicine, The University of Alabama, Birmingham, Alabama, USA.
Yueqin ZhaoCenter for Drug Evaluation and Research, Office of Translational Sciences, US Food and Drug Administration, Silver Spring, Maryland, USA.
Rebekah HeckmannDepartment of Emergency Medicine, Yale University, New Haven, Connecticut, USA.
United States Food and Drug Administration · USYale University · USMayo Clinic in Florida · USUniversity of Alabama at Birmingham · USCedars-Sinai Medical Center · USMayo Clinic · USMayo Clinic in Arizona · USRapid City Regional Hospital · USUniversity of Dundee · GB

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Yale-Mayo FDA Center for Excellence in Regulatory Science and InnovationU01FD005938 · FDA · YALE UNIVERSITY · PI Joseph Solomon Ross · 2016 to 2026
$25.4M
The National Dental PBRN - Administrative CoreU19DE028717 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GILBERT, GREGG H · 2019 to 2025
$23.5M
Leveraging Physician Networks to Improve Care and Outcomes for Low-Income PopulationsR01HL144644 · NHLBI · YALE UNIVERSITY · PI NDUMELE, CHIMA · 2019 to 2021
$1.6M
AHRQ HHS R01 HS022882AHRQ HHS R01 HS025164FDA HHS U01 FD005938NCATS NIH HHS UL1 TR001863NHLBI NIH HHS R01 HL144644NIDCR NIH HHS U19 DE028717
6 · The paper itself

Abstract

introductionOpioid analgesics are often used to treat moderate-to-severe acute non-cancer pain; however, there is little high-quality evidence to guide clinician prescribing. An essential element to developing evidence-based guidelines is a better understanding of pain management and pain control among individuals experiencing acute pain for various common diagnoses. METHODS AND ANALYSIS: This multicentre prospective observational study will recruit 1550 opioid-naïve participants with acute pain seen in diverse clinical settings including primary/urgent care, emergency departments and dental clinics. Participants will be followed for 6 months with the aid of a patient-centred health data aggregating platform that consolidates data from study questionnaires, electronic health record data on healthcare services received, prescription fill data from pharmacies, and activity and sleep data from a Fitbit activity tracker. Participants will be enrolled to represent diverse races and ethnicities and pain conditions, as well as geographical diversity. Data analysis will focus on assessing patients' patterns of pain and opioid analgesic use, along with other pain treatments; associations between patient and condition characteristics and patient-centred outcomes including resolution of pain, satisfaction with care and long-term use of opioid analgesics; and descriptive analyses of patient management of leftover opioids. ETHICS AND DISSEMINATION: This study has received approval from IRBs at each site. Results will be made available to participants, funders, the research community and the public. TRIAL REGISTRATION NUMBER: NCT04509115.

Indexed as

Acute PainAnalgesics, OpioidPain ManagementPatient-Centered CareEmergency Service, HospitalHumansMulticenter Studies as TopicObservational Studies as TopicOpioid-Related DisordersProspective StudiesAnalgesics, Opioidaccident & emergency medicineoral & maxillofacial surgerypain managementprimary care

Identifiers

PMID35790333
PMCPMC9258513
OpenAlexW4283829144

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.