Evidence map›Paper›PMID 35790241›Full record

ArticleCanadian journal of surgery. Journal canadien de chirurgie

Outcomes of liver transplant recipients with high MELD scores: an experience from a Canadian centre.

Michael S Bleszynski, Subin Punnen, Sameer Desai, Trana Hussaini, Vladimir Marquez, Eric M Yoshida, Saumya Jayakumar, Stephanie Chartier-Plante, Maja Segedi, Charles H Scudamore and 3 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Canadian journal of surgery. Journal canadien de chirurgie. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Michael S BleszynskiFrom the Department of Surgery, Division of General Surgery, University of British Columbia, Vancouver, B.C. (Bleszynski, Punnen, Desai Chartier-Plante, Segedi, Scudamore, Chung, Buczkowski, Kim); the Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, B.C. (Hussaini); and the Department of Medicine, Division of Gastroenterology, University of British Columbia Vancouver, B.C. (Marquez, Yoshida, Jayakumar).
Subin PunnenFrom the Department of Surgery, Division of General Surgery, University of British Columbia, Vancouver, B.C. (Bleszynski, Punnen, Desai Chartier-Plante, Segedi, Scudamore, Chung, Buczkowski, Kim); the Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, B.C. (Hussaini); and the Department of Medicine, Division of Gastroenterology, University of British Columbia Vancouver, B.C. (Marquez, Yoshida, Jayakumar).
Sameer DesaiFrom the Department of Surgery, Division of General Surgery, University of British Columbia, Vancouver, B.C. (Bleszynski, Punnen, Desai Chartier-Plante, Segedi, Scudamore, Chung, Buczkowski, Kim); the Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, B.C. (Hussaini); and the Department of Medicine, Division of Gastroenterology, University of British Columbia Vancouver, B.C. (Marquez, Yoshida, Jayakumar).
Trana HussainiFrom the Department of Surgery, Division of General Surgery, University of British Columbia, Vancouver, B.C. (Bleszynski, Punnen, Desai Chartier-Plante, Segedi, Scudamore, Chung, Buczkowski, Kim); the Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, B.C. (Hussaini); and the Department of Medicine, Division of Gastroenterology, University of British Columbia Vancouver, B.C. (Marquez, Yoshida, Jayakumar).
Vladimir MarquezFrom the Department of Surgery, Division of General Surgery, University of British Columbia, Vancouver, B.C. (Bleszynski, Punnen, Desai Chartier-Plante, Segedi, Scudamore, Chung, Buczkowski, Kim); the Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, B.C. (Hussaini); and the Department of Medicine, Division of Gastroenterology, University of British Columbia Vancouver, B.C. (Marquez, Yoshida, Jayakumar).
Eric M YoshidaFrom the Department of Surgery, Division of General Surgery, University of British Columbia, Vancouver, B.C. (Bleszynski, Punnen, Desai Chartier-Plante, Segedi, Scudamore, Chung, Buczkowski, Kim); the Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, B.C. (Hussaini); and the Department of Medicine, Division of Gastroenterology, University of British Columbia Vancouver, B.C. (Marquez, Yoshida, Jayakumar).
Saumya JayakumarFrom the Department of Surgery, Division of General Surgery, University of British Columbia, Vancouver, B.C. (Bleszynski, Punnen, Desai Chartier-Plante, Segedi, Scudamore, Chung, Buczkowski, Kim); the Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, B.C. (Hussaini); and the Department of Medicine, Division of Gastroenterology, University of British Columbia Vancouver, B.C. (Marquez, Yoshida, Jayakumar).
Stephanie Chartier-PlanteFrom the Department of Surgery, Division of General Surgery, University of British Columbia, Vancouver, B.C. (Bleszynski, Punnen, Desai Chartier-Plante, Segedi, Scudamore, Chung, Buczkowski, Kim); the Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, B.C. (Hussaini); and the Department of Medicine, Division of Gastroenterology, University of British Columbia Vancouver, B.C. (Marquez, Yoshida, Jayakumar).
Maja SegediFrom the Department of Surgery, Division of General Surgery, University of British Columbia, Vancouver, B.C. (Bleszynski, Punnen, Desai Chartier-Plante, Segedi, Scudamore, Chung, Buczkowski, Kim); the Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, B.C. (Hussaini); and the Department of Medicine, Division of Gastroenterology, University of British Columbia Vancouver, B.C. (Marquez, Yoshida, Jayakumar).
Charles H ScudamoreFrom the Department of Surgery, Division of General Surgery, University of British Columbia, Vancouver, B.C. (Bleszynski, Punnen, Desai Chartier-Plante, Segedi, Scudamore, Chung, Buczkowski, Kim); the Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, B.C. (Hussaini); and the Department of Medicine, Division of Gastroenterology, University of British Columbia Vancouver, B.C. (Marquez, Yoshida, Jayakumar).
Stephen ChungFrom the Department of Surgery, Division of General Surgery, University of British Columbia, Vancouver, B.C. (Bleszynski, Punnen, Desai Chartier-Plante, Segedi, Scudamore, Chung, Buczkowski, Kim); the Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, B.C. (Hussaini); and the Department of Medicine, Division of Gastroenterology, University of British Columbia Vancouver, B.C. (Marquez, Yoshida, Jayakumar).
Andrzej K BuczkowskiFrom the Department of Surgery, Division of General Surgery, University of British Columbia, Vancouver, B.C. (Bleszynski, Punnen, Desai Chartier-Plante, Segedi, Scudamore, Chung, Buczkowski, Kim); the Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, B.C. (Hussaini); and the Department of Medicine, Division of Gastroenterology, University of British Columbia Vancouver, B.C. (Marquez, Yoshida, Jayakumar).
Peter T W KimFrom the Department of Surgery, Division of General Surgery, University of British Columbia, Vancouver, B.C. (Bleszynski, Punnen, Desai Chartier-Plante, Segedi, Scudamore, Chung, Buczkowski, Kim); the Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, B.C. (Hussaini); and the Department of Medicine, Division of Gastroenterology, University of British Columbia Vancouver, B.C. (Marquez, Yoshida, Jayakumar) peter.kim@vch.ca.
University of British Columbia · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe frequency with which patients with high Model for End-Stage Liver Disease (MELD) scores undergo liver transplantation has been increasing. Canadian literature regarding the outcomes of liver transplantation in recipients with high MELD scores is limited. The primary objective of this study was to assess patient and graft survival among recipients with high (> 35) and low (≤ 35) MELD scores. Secondary objectives were to potentially identify independent predictors of graft failure and patient mortality.

methodsWe conducted a retrospective chart review of patients undergoing liver transplantation at a single Canadian centre from 2012 to 2017.

resultsA total of 332 patients were included in the study: 280 patients had a MELD score of 35 or lower, and 52 had a MELD score above 35. Patients with high MELD scores had higher rates of pretransplant acute kidney injury and dialysis (

conclusionNo difference in patient mortality was found between MELD groups. Graft survival was significantly lower in recipients with MELD scores above 35. D-MELD may potentially be used as an adjunct in determining risk of graft failure in recipients with high MELD scores.

Indexed as

Acute Kidney InjuryEnd Stage Liver DiseaseLiver TransplantationCanadaHumansRetrospective StudiesSeverity of Illness IndexTreatment Outcome

Identifiers

PMID35790241
PMCPMC9337864
OpenAlexW4283827678

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.