ArticleNature2022
Apoptotic brown adipocytes enhance energy expenditure via extracellular inosine.
Open access · hybridAbstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed, 1 pooled it
16.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
89 citing papers in PubMed, 1 synthesis or guideline pooled it, 143 citations in OpenAlex.
- Thermogenic Differentiation of Human Adipocyte Precursors in Culture: A Systematic Review.Cells · 2025Pooled it
- 6 weeks of fartlek-style endurance training does not alter physiological responses to mild cold exposure but attenuates the cold-induced plasma noradrenaline response: A randomized, matched control trial.Journal of clinical & translational endocrinology · 2026Article
- Dietary Nucleotides as Potential Modulators of Inflammatory and Metabolic Pathways with Implications for Insulin Resistance.International journal of molecular sciences · 2026Review
- Comparative compositional analysis of commercially produced mule duck and Landes goose foie gras.Poultry science · 2026Article
- Exercise and Fat: A Primer.Sports medicine - open · 2026Review
- Identification and validation of brown adipocyte-related key genes in ST-segment elevated myocardial infarction.Journal of cardiothoracic surgery · 2026Article
- Phosphomannomutase 1 restrains adipose thermogenic programming via inosine signaling.Molecular metabolism · 2026Article
- Cars2-Mediated Cysteine Catabolism Drives Brown Fat Development and Thermogenesis Through Persulfidating EBF2.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Advances in research on thermogenic substances.Journal of physiological anthropology · 2026Review
- Inosine promotes erythrocyte metabolic reprogramming and restores oxygen release for rejuvenation via 2,3-BPG-PNP axis.Cell discovery · 2026Article
- Antibiotic-Mediated Modulation of the Gut Microbiome Identifies Taurine as a Modulator of Adipocyte Function Through TGR5 Signaling.International journal of molecular sciences · 2026Article
- Advances in Adipose Tissue Biology.Endocrine reviews · 2026Review
- Adipose tissue releases nucleosides.American journal of physiology. Cell physiology · 2026Article
- From endocrine to immune: therapeutic potential of brown adipose tissue in remodelling the cardiovascular immune microenvironment.Frontiers in immunology · 2026Review
- Raspberry aqueous extract ameliorates MAFLD in mice by regulating gut microbiota and purine metabolism.Frontiers in nutrition · 2026Article
- Berberine combined with stachyose protects against obesity by modulating gut microbiota and increasing leptin sensitivity.Science China. Life sciences · 2026Article
- From fat to fate: how aging adipose tissue drives systemic metabolic aging.Biogerontology · 2025Review
- Mitochondrial membrane junction-mediated ATP channeling drives activity-dependent glucose metabolism.bioRxiv : the preprint server for biology · 2025Article
- The Artemisia argyi oil reduces high-fat diet-induced obesity by enhancing thermogenesis in brown adipose tissue.NPJ science of food · 2025Article
- Purinergic adipocyte-macrophage crosstalk promotes degeneration of thermogenic brown adipose tissue.EMBO reports · 2025Article
29 more citing papers are in PubMed but not listed here.
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Authors and funding
20 authors at 4 institutions in 2 countries.
Birte Niemann *Institute of Pharmacology and Toxicology, University Hospital, University of Bonn, Bonn, Germany. Bini@uni-bonn.de.ORCID http://orcid.org/0000-0002-0128-803X
Saskia Haufs-Brusberg *Institute of Pharmacology and Toxicology, University Hospital, University of Bonn, Bonn, Germany.
Laura PuetzInstitute of Pharmacology and Toxicology, University Hospital, University of Bonn, Bonn, Germany.
Martin FeickertInstitute of Pharmacology and Toxicology, University Hospital, University of Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0002-1911-7810
Michelle Y JaecksteinDepartment of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Anne HoffmannHelmholtz Institute for Metabolic Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany.
Jelena ZurkovicInstitute of Pharmacology and Toxicology, University Hospital, University of Bonn, Bonn, Germany.
Markus HeineDepartment of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Eva-Maria TrautmannInstitute for Diabetes and Obesity, Helmholtz Center Munich, Neuherberg, Germany.
Christa E MüllerPharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0002-0013-6624
Anke TönjesMedical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany.
Christian SchleinInstitute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Azin JafariClinic and Polyclinic for General, Visceral, Thoracic and Vascular Surgery, University Hospital, University of Bonn, Bonn, Germany.
Holger K EltzschigDepartment of Anesthesiology, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, Texas, USA.ORCID http://orcid.org/0000-0002-5676-6473
Thorsten GnadInstitute of Pharmacology and Toxicology, University Hospital, University of Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0003-0169-3067
Matthias BlüherHelmholtz Institute for Metabolic Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany.ORCID http://orcid.org/0000-0003-0208-2065
Natalie KrahmerInstitute for Diabetes and Obesity, Helmholtz Center Munich, Neuherberg, Germany.
Peter KovacsMedical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany.ORCID http://orcid.org/0000-0002-0290-5423
Joerg HeerenDepartment of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Alexander PfeiferInstitute of Pharmacology and Toxicology, University Hospital, University of Bonn, Bonn, Germany. Alexander.Pfeifer@uni-bonn.de.ORCID http://orcid.org/0000-0001-8805-6831
University of Bonn · DEHelmholtz Zentrum München · DEUniversität Hamburg · DEThe University of Texas Health Science Center at Houston · US
Funding
microRNA miR-147 Dampens Alveolar Epithelial Inflammation During ARDSR01HL154720 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ELTZSCHIG, HOLGER K. · 2021 to 2024
$2.2MTargeting MicroRNA miR-122 for the Treatment of Perioperative Liver InjuryR01DK122796 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ELTZSCHIG, HOLGER K., JU, CYNTHIA · 2020 to 2023
$1.8MMicroRNA Shuttling during Acute Respiratory Distress SyndromeR01HL133900 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ELTZSCHIG, HOLGER K. · 2017 to 2020
$1.5MResearch Training of Anesthesiology Physician-ScientistsT32GM135118 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Holger K. Eltzschig, Cynthia Ju · 2022 to 2026
$1.1MNHLBI NIH HHS R01 HL133900NHLBI NIH HHS R01 HL154720NIDDK NIH HHS R01 DK122796NIGMS NIH HHS T32 GM135118
Abstract
Brown adipose tissue (BAT) dissipates energy
Indexed as
Adipocytes, BrownAdipose Tissue, BrownEnergy MetabolismInosineAdipose Tissue, WhiteAnimalsEquilibrative Nucleoside Transporter 1HumansMiceObesityThermogenesisUncoupling Protein 1Equilibrative Nucleoside Transporter 1InosineSLC29A1 protein, humanSLC29A1 protein, mouseUCP1 protein, humanUncoupling Protein 1
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.