ArticleAngewandte Chemie (International ed. in English)2022
Cathodic Radical Cyclisation of Aryl Halides Using a Strongly-Reducing Catalytic Mediator in Flow.
Article in Angewandte Chemie (International ed. in English), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 47 citations in OpenAlex.
- Homogeneous catalysis in continuous flow integrating photocatalysis, electrocatalysis, and automation technologies.Communications chemistry · 2025Review
- Prediction and optimization of electrochemical oxidation efficiency using machine learning: Insights from carbon-based anodes for water treatment.Journal of environmental management · 2025Article
- Photoredox-Catalyzed Hydroalkylation of C(spChemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Electrochemical Flow Reactors: Mass Transport, iR Drop, and Membrane-Free Performance with In-Line Analysis.ACS electrochemistry · 2025Article
- Iodoarene Activation: Take a Leap Forward toward Green and Sustainable Transformations.Chemical reviews · 2025Review
- Paired Electrolysis Enables Reductive Heck Coupling of Unactivated (Hetero)Aryl Halides and Alkenes.Angewandte Chemie (International ed. in English) · 2024Article
- Electroreductive deuteroarylation of alkenes enabled by an organo-mediator.Chemical science · 2024Article
- Bromide-Mediated Silane Oxidation: A Practical Counter-Electrode Process for Nonaqueous Deep Reductive Electrosynthesis.JACS Au · 2024Article
- Allylation ofAngewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2024Article
- Allylation of C-, N-, and O-Nucleophiles via a Mechanochemically-Driven Tsuji-Trost Reaction Suitable for Late-Stage Modification of Bioactive Molecules.Angewandte Chemie (International ed. in English) · 2024Article
- Transition-metal-catalyst-free electroreductive alkene hydroarylation with aryl halides under visible-light irradiation.Beilstein journal of organic chemistry · 2024Article
- Organomediated electrochemical fluorosulfonylation of aryl triflates via selective C-O bond cleavage.Nature communications · 2023Article
- Electroreductive Radical Borylation of Unactivated (Hetero)Aryl Chlorides Without Light by Using Cumulene-Based Redox Mediators.Angewandte Chemie (International ed. in English) · 2023Article
- Electroreductively Induced Radicals for Organic Synthesis.Molecules (Basel, Switzerland) · 2023Review
- Cathodic Radical Cyclisation of Aryl Halides Using a Strongly-Reducing Catalytic Mediator in Flow.Angewandte Chemie (International ed. in English) · 2022Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Electro-reductive radical cyclisation of aryl halides affords the corresponding hetero- and carbo-cycles in an undivided flow reactor equipped with steel and carbon electrodes using an organic mediator. A dissolving metal anode is not needed, and the mediator can be employed in a sub-stoichiometric amount (0.05 equiv), increasing the practical utility of cathodic radical cyclisation. The methodology is applied to O-, N-, and C-tethers, yielding tricyclic fused and spiro systems. In the absence of mediator, the major pathway is hydrogenolysis of the C-X bond, a 2 e
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.