Evidence map›Paper›PMID 35789966›Full record

ArticleFrontiers in nutrition2022

Milk of Cow and Goat, Immunized by Recombinant Protein Vaccine ZF-UZ-VAC2001(Zifivax), Contains Neutralizing Antibodies Against SARS-CoV-2 and Remains Active After Standard Milk Pasteurization.

Victoria Garib, Stefani Katsamaki, Shahlo Turdikulova, Yuliya Levitskaya, Nodira Zahidova, Galina Bus, Kristina Karamova, Manona Rakhmedova, Nigora Magbulova, Alexander Bruhov and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Victoria GaribDivision of Immunopathology, Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria.
Stefani KatsamakiCentre of Advanced Technology, Ministry of Innovative Development of the Republic of Uzbekistan, Tashkent, Uzbekistan.
Shahlo TurdikulovaCentre of Advanced Technology, Ministry of Innovative Development of the Republic of Uzbekistan, Tashkent, Uzbekistan.
Yuliya LevitskayaInternational Centre of Molecular Allergology, Ministry of Innovative Development of the Republic of Uzbekistan, Tashkent, Uzbekistan.
Nodira ZahidovaScientific and Diagnostical Centre of Laboratory Technology "Defactum Laboratories", Tashkent, Uzbekistan.
Galina BusScientific and Diagnostical Centre of Laboratory Technology "Defactum Laboratories", Tashkent, Uzbekistan.
Kristina KaramovaInternational Centre of Molecular Allergology, Ministry of Innovative Development of the Republic of Uzbekistan, Tashkent, Uzbekistan.
Manona RakhmedovaInternational Centre of Molecular Allergology, Ministry of Innovative Development of the Republic of Uzbekistan, Tashkent, Uzbekistan.
Nigora MagbulovaInternational Centre of Molecular Allergology, Ministry of Innovative Development of the Republic of Uzbekistan, Tashkent, Uzbekistan.
Alexander BruhovInternational Centre of Molecular Allergology, Ministry of Innovative Development of the Republic of Uzbekistan, Tashkent, Uzbekistan.
Firuz Y GaribInternational Centre of Molecular Allergology, Ministry of Innovative Development of the Republic of Uzbekistan, Tashkent, Uzbekistan.
Ibrokhim Y AbdurakhmonovCentre of Genomics and Bioinformatics, Academy of Sciences of Uzbekistan, Tashkent, Uzbekistan.
Ministry of Innovative Development of the Republic of UzbekistanTashkent Pediatric Medical Institute · UZAcademy of Sciences Republic of Uzbekistan · UZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Here, we present the first experimental validation of the possibility for obtaining immune milk with neutralizing antibodies against SARS-CoV-2 from vaccinated cows and goat using approved recombinant protein human coronavirus vaccine, ZF-UZ-VAC2001, in the Republic of Uzbekistan. In the period of 2 weeks after first vaccination, we detected the neutralizing antibodies against coronavirus in the blood serum of vaccinated animals. The neutralizing activity, in its peak on the 21st day after receiving the third dose (77th day from first dose), was effective in neutralization test using a live SARS-CoV-2 in Vero E6 cells, even after 120-fold serum titration. In cows receiving three dose of human vaccine, the MAGLUMI

Indexed as

bovine immunoglobulinsimmune milkneutralizing antibody (nAb)passive immunizationSARS-CoV-2vaccinationZF-UZ-VAC2001

Identifiers

PMID35789966
PMCPMC9249723
OpenAlexW4282585396

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.