Evidence map›Paper›PMID 35789856›Full record

ArticleiScience2022

A Tead1-Apelin axis directs paracrine communication from myogenic to endothelial cells in skeletal muscle.

Umji Lee, Pascal Stuelsatz, Sonia Karaz, David W McKellar, Julie Russeil, Maria Deak, Iwijn De Vlaminck, Christoph Lepper, Bart Deplancke, Benjamin D Cosgrove and 1 more

Open access · goldAbstract read
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 24 citations in OpenAlex.

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  17. Exercise metabolism and adaptation in skeletal muscle.Nature reviews. Molecular cell biology · 2023
    Review
  18. Apelin as a Potential Regulator of Peak Athletic Performance.International journal of molecular sciences · 2023
    Article
  19. Review
  20. Exerkines and osteoarthritis.Frontiers in physiology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Umji LeeNestlé Institute of Health Sciences, Nestlé Research, Lausanne, Switzerland.
Pascal StuelsatzNestlé Institute of Health Sciences, Nestlé Research, Lausanne, Switzerland.
Sonia KarazNestlé Institute of Health Sciences, Nestlé Research, Lausanne, Switzerland.
David W McKellarMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
Julie RusseilSchool of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Maria DeakNestlé Institute of Health Sciences, Nestlé Research, Lausanne, Switzerland.
Iwijn De VlaminckMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
Christoph LepperDepartment of Physiology and Cell Biology, The Ohio State University College of Medicine, Columbus, OH, USA.
Bart DeplanckeSchool of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Benjamin D CosgroveMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
Jerome N FeigeNestlé Institute of Health Sciences, Nestlé Research, Lausanne, Switzerland.
Cornell University · USNestlé (Switzerland) · CHÉcole Polytechnique Fédérale de Lausanne · CHThe Ohio State University · US

Funding

Revealing muscle stem cell heterogeneity in mice and humans through deep single-cell analysisR01AG058630 · NIA · CORNELL UNIVERSITY · PI COSGROVE, BENJAMIN DAVID · 2018 to 2022
$2.9M
Regulation of Muscle Stem Cell Number via Paracrine SignalingR01AR078231 · NIAMS · OHIO STATE UNIVERSITY · PI LEPPER, CHRISTOPH · 2021 to 2025
$1.9M
NIAMS NIH HHS R01 AR078231NIA NIH HHS R01 AG058630
6 · The paper itself

Abstract

Apelin (Apln) is a myokine that regulates skeletal muscle plasticity and metabolism and declines during aging. Through a yeast one-hybrid transcription factor binding screen, we identified the TEA domain transcription factor 1 (Tead1) as a novel regulator of the

Indexed as

Cell biologyMolecular biologyMolecular mechanism of gene regulation

Identifiers

PMID35789856
PMCPMC9250016
OpenAlexW4282833336

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.