Evidence map›Paper›PMID 35789845›Full record

ArticleiScience2022

Lipoxins reduce obesity-induced adipose tissue inflammation in 3D-cultured human adipocytes and explant cultures.

Matúš Soták, Meenu Rohini Rajan, Madison Clark, Matthew Harms, Alankrita Rani, Jamie D Kraft, David Tandio, Tong Shen, Kamil Borkowski, Oliver Fiehn and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Inflammation and resolution in obesity.Nature reviews. Endocrinology · 2025 · on this map
    Review
  7. Attenuation of adipose tissue inflammation by pro-resolving lipid mediators.Current opinion in endocrine and metabolic research · 2024
    Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 6 institutions in 2 countries.

Matúš SotákDepartment of Molecular and Clinical Medicine, Wallenberg Laboratory, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 40530 Gothenburg, Sweden.
Meenu Rohini RajanDepartment of Molecular and Clinical Medicine, Wallenberg Laboratory, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 40530 Gothenburg, Sweden.
Madison ClarkDepartment of Molecular and Clinical Medicine, Wallenberg Laboratory, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 40530 Gothenburg, Sweden.
Matthew HarmsBioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Alankrita RaniDepartment of Molecular and Clinical Medicine, Wallenberg Laboratory, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 40530 Gothenburg, Sweden.
Jamie D KraftDepartment of Molecular and Clinical Medicine, Wallenberg Laboratory, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 40530 Gothenburg, Sweden.
David TandioDepartment of Molecular and Clinical Medicine, Wallenberg Laboratory, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 40530 Gothenburg, Sweden.
Tong ShenNIH West Coast Metabolomics Center, Genome Center, University of California Davis, Davis, CA 95616, USA.
Kamil BorkowskiNIH West Coast Metabolomics Center, Genome Center, University of California Davis, Davis, CA 95616, USA.
Oliver FiehnNIH West Coast Metabolomics Center, Genome Center, University of California Davis, Davis, CA 95616, USA.
John W NewmanNIH West Coast Metabolomics Center, Genome Center, University of California Davis, Davis, CA 95616, USA.
Marianne Quiding-JärbrinkDepartment of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, 40530 Gothenburg, Sweden.
Christina BiörserudDepartment of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Peter ApelgrenDepartment of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Trude StaalesenDepartment of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Carolina E HagbergDivision of Cardiovascular Medicine, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
Jeremie BoucherWallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, 40530 Gothenburg, Sweden.
Ville WalleniusDepartment of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Stephan LangeDepartment of Molecular and Clinical Medicine, Wallenberg Laboratory, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 40530 Gothenburg, Sweden.
Emma BörgesonDepartment of Molecular and Clinical Medicine, Wallenberg Laboratory, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 40530 Gothenburg, Sweden.
University of Gothenburg · SEUniversity of California, Davis · USSahlgrenska University Hospital · SEAstraZeneca (Sweden) · SEKarolinska Institutet · SEUniversity of California, San Diego · US

Funding

West Coast Central Comprehensive Metabolomics Resource Core (WC3MRC)U24DK097154 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI FIEHN, OLIVER · 2012 to 2017
$9.9M
The role of obscurin and Obsl1 as key determinants for diastolic functionR01HL152251 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHO, YOSHITAKE, LANGE, STEPHAN · 2021 to 2024
$2.3M
Signaling Pathways in Dilated CardiomyopathyR01HL128457 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LANGE, STEPHAN · 2015 to 2019
$1.9M
Cullin mediated protein turnover in skeletal and cardiac musclesR00HL107744 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LANGE, STEPHAN · 2013 to 2015
$726k
Cullin mediated protein turnover in skeletal and cardiac musclesK99HL107744 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LANGE, STEPHAN · 2011 to 2012
$178k
NHLBI NIH HHS K99 HL107744NHLBI NIH HHS R00 HL107744NHLBI NIH HHS R01 HL128457NHLBI NIH HHS R01 HL152251NIDDK NIH HHS U24 DK097154
6 · The paper itself

Abstract

Adipose tissue inflammation drives obesity-related cardiometabolic diseases. Enhancing endogenous resolution mechanisms through administration of lipoxin A

Indexed as

Biological sciencesCell biologyHuman metabolismPhysiologyPrecision medicine

Identifiers

PMID35789845
PMCPMC9249816
OpenAlexW4283825571

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.