ArticleiScience2022
Modulation of mean luminance improves binocular balance across spatial frequencies in amblyopia.
Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- The impact of amblyopia, reduced viewing conditions and binocular vision on reading ability: a narrative review.Frontiers in neuroscience · 2026Review
- Temporal Frequency Modulation of Binocular Balance in Normal and Amblyopic Vision.Investigative ophthalmology & visual science · 2025Article
- Reduced Monocular Luminance Promotes Fusion But Not Mixed Perception in Amblyopia.Investigative ophthalmology & visual science · 2024Article
- Effects of Monocular Flicker on Binocular Imbalance in Amblyopic and Nonamblyopic Adults.Investigative ophthalmology & visual science · 2024Article
- Rapid Alternate Flicker Modulates Binocular Interaction in Adults With Abnormal Binocular Vision.Investigative ophthalmology & visual science · 2023Article
- Negligible contribution of adaptation of ocular opponency neurons to the effect of short-term monocular deprivation.Frontiers in psychology · 2023Article
- Issues Revisited: Shifts in Binocular Balance Depend on the Deprivation Duration in Normal and Amblyopic Adults.Ophthalmology and therapy · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Amblyopia is a visual impairment that perturbs binocular balance at high spatial frequencies in favor of the fellow eye. Studies reveal that amblyopes who had been treated with monocular therapies still show imbalance. Binocular balance is achieved when both eyes' inputs are weighed equally. A reduced light can diminish the dimmed eye's weight in binocular combination. In this study, we examined if binocular balance across spatial frequencies could be improved by reducing the luminance of the fellow eye in adult amblyopes. By doing so, we relieved their binocular imbalance across spatial frequencies. Also, normal observers showed amblyopic binocular imbalance when the dominant eye's light level was dimmed. Therefore, reducing the luminance in the unaffected eye in amblyopia mitigated the binocular imbalance, whereas doing so in normal adults simulated the amblyopic imbalance across spatial frequencies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.