Evidence map›Paper›PMID 35789834›Full record

ArticleiScience2022

Single-cell transcriptional regulation and genetic evolution of neuroendocrine prostate cancer.

Ziwei Wang, Tao Wang, Danni Hong, Baijun Dong, Yan Wang, Huaqiang Huang, Wenhui Zhang, Bijun Lian, Boyao Ji, Haoqing Shi and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 58 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 7 institutions in 3 countries.

Ziwei WangDepartment of Urology, Changhai Hospital, Naval Medical University, Shanghai 200433, China.
Tao WangDepartment of Urology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Danni HongState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, China.
Baijun DongDepartment of Urology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
Yan WangDepartment of Urology, Changhai Hospital, Naval Medical University, Shanghai 200433, China.
Huaqiang HuangState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, China.
Wenhui ZhangDepartment of Urology, Changhai Hospital, Naval Medical University, Shanghai 200433, China.
Bijun LianDepartment of Urology, the 903rd PLA Hospital, Hangzhou, Zhejiang 310012, China.
Boyao JiDepartment of Histology and Embryology, Naval Medical University, Shanghai 200433, China.
Haoqing ShiDepartment of Urology, Changhai Hospital, Naval Medical University, Shanghai 200433, China.
Min QuDepartment of Urology, Changhai Hospital, Naval Medical University, Shanghai 200433, China.
Xu GaoDepartment of Urology, Changhai Hospital, Naval Medical University, Shanghai 200433, China.
Daofeng LiDepartment of Genetics, Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA.
Colin CollinsDepartment of Urologic Sciences, University of British Columbia, Canada.
Gonghong WeiFudan University Shanghai Cancer Center, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Shanghai Medical College of Fudan University, Shanghai, China.
Chuanliang XuDepartment of Urology, Changhai Hospital, Naval Medical University, Shanghai 200433, China.
Hyung Joo LeeDepartment of Genetics, Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA.
Jialiang HuangState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, China.
Jing LiDepartment of Bioinformatics, Center for Translational Medicine, Naval Medical University, Shanghai 200433, China.
Second Military Medical University · CNXiamen University · CNWashington University in St. Louis · USFirst Affiliated Hospital of Zhengzhou University · CNShanghai Jiao Tong University · CNShanghai Medical College of Fudan University · CNUniversity of British Columbia · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroendocrine prostate cancer (NEPC) is a lethal subtype of prostate cancer, with a 10% five-year survival rate. However, little is known about its origin and the mechanisms governing its emergence. Our study characterized ADPC and NEPC in prostate tumors from 7 patients using scRNA-seq. First, we identified two NEPC gene expression signatures representing different phases of

Indexed as

CancerCancer systems biologyTranscriptomics

Identifiers

PMID35789834
PMCPMC9250006
OpenAlexW4282574692

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.