Evidence map›Paper›PMID 35789750›Full record

ArticleiScience2022

Immunomodulatory LncRNA on antisense strand of ICAM-1 augments SARS-CoV-2 infection-associated airway mucoinflammatory phenotype.

Dinesh Devadoss, Arpan Acharya, Marko Manevski, Dominika Houserova, Michael D Cioffi, Kabita Pandey, Madhavan Nair, Prem Chapagain, Mehdi Mirsaeidi, Glen M Borchert and 2 more

Open access · goldAbstract read
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Dinesh DevadossDepartment of Immunology and Nano-Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA.
Arpan AcharyaDepartment of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Marko ManevskiDepartment of Immunology and Nano-Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA.
Dominika HouserovaDepartment of Pharmacology, University of South Alabama, Mobile, AL 36688, USA.
Michael D CioffiDepartment of Physics, Florida International University, Miami, FL 33199, USA.
Kabita PandeyDepartment of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Madhavan NairDepartment of Immunology and Nano-Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA.
Prem ChapagainDepartment of Physics, Florida International University, Miami, FL 33199, USA.
Mehdi MirsaeidiMiller School of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, University of Miami, Miami, FL 33136, USA.
Glen M BorchertDepartment of Pharmacology, University of South Alabama, Mobile, AL 36688, USA.
Siddappa N ByrareddyDepartment of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Hitendra S ChandDepartment of Immunology and Nano-Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA.
Florida International University · USUniversity of Nebraska Medical Center · USUniversity of South Alabama · USUniversity of Miami · US

Funding

Epigenetic mechanisms underlying cannabinoid modulation of neuroinflammation in HIV/SIV infection-supplementR01DA052845 · NIDA · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI BYRAREDDY, SIDDAPPA N, MOHAN, MAHESH · 2020 to 2024
$4.0M
Neuroimmunology of Disease Training ProgramT32NS105594 · NINDS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Aditya N Bade, Howard E Gendelman · 2018 to 2026
$1.4M
Novel long noncoding RNAs in the airway mucous responseR21AI144374 · NIAID · FLORIDA INTERNATIONAL UNIVERSITY · PI LAKSHMANA, MADEPALLI KRISHNAPPA · 2019 to 2020
$625k
LncRNA in Alzheimer's Disease-Associated Neuroinflammation and NeurodegenerationR21AI152937 · NIAID · FLORIDA INTERNATIONAL UNIVERSITY · PI CHAND, HITENDRA SINGH · 2020 to 2021
$597k
NIAID NIH HHS R21 AI144374NIAID NIH HHS R21 AI152937NIDA NIH HHS R01 DA052845NINDS NIH HHS T32 NS105594
6 · The paper itself

Abstract

Noncoding RNAs are important regulators of mucoinflammatory response, but little is known about the contribution of airway long noncoding RNAs (lncRNAs) in COVID-19. RNA-seq analysis showed a more than 4-fold increased expression of

Indexed as

ImmunologyMolecular biologyMolecular mechanism of gene regulationVirology

Identifiers

PMID35789750
PMCPMC9242679
OpenAlexW4283747502

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.