Evidence map›Paper›PMID 35789452›Full record

ArticleInternational urology and nephrology2022

The effect of a 9-month hybrid intradialytic exercise training program on nerve conduction velocity parameters in patients receiving hemodialysis therapy.

Stefania S Grigoriou, Christina Karatzaferi, Christoforos D Giannaki, Gianna Patramani, Christina Vogiatzi, Georgia I Mitrou, Ioannis Stefanidis, Giorgos K Sakkas

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in International urology and nephrology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07780175 (The Effects of Long-Term Hybrid Intradialytic Exercise on Cognitive Function and Quality of Life in End-Stage Kidney Disease Patients), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07780175 naactive not recruitingnot on this mapstarted 2026, after this paper: background citation

The Effects of Long-Term Hybrid Intradialytic Exercise on Cognitive Function and Quality of Life in End-Stage Kidney Disease Patients: A Randomized Controlled Trial

TypeinterventionalSponsorUniversity of ThessalyRan2026 to 2027Enrolled60ConditionsSupportive Care, Exercise Adaptations, Exercise Training Therapy, Clinical ExerciseArmsResistance Training, Aerobic training, Combination Training
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 3 countries.

Stefania S GrigoriouLive Lab, Department of PE and Sport Science, University of Thessaly, 42100, Trikala, Greece.
Christina KaratzaferiLive Lab, Department of PE and Sport Science, University of Thessaly, 42100, Trikala, Greece.
Christoforos D GiannakiDepartment of Life and Health Sciences, University of Nicosia, Nicosia, Cyprus.
Gianna PatramaniSchool of Health Science, Department of Medicine, University of Thessaly, Larissa, Greece.
Christina VogiatziSchool of Health Science, Department of Medicine, University of Thessaly, Larissa, Greece.
Georgia I MitrouLive Lab, Department of PE and Sport Science, University of Thessaly, 42100, Trikala, Greece.
Ioannis StefanidisSchool of Health Science, Department of Medicine, University of Thessaly, Larissa, Greece.
Giorgos K SakkasLive Lab, Department of PE and Sport Science, University of Thessaly, 42100, Trikala, Greece. gsakkas@uth.gr.ORCID http://orcid.org/0000-0002-2462-995X
University of Thessaly · GRUniversity of Nicosia · CY

Funding

H2020 Marie Skłodowska-Curie Actions 645648
6 · The paper itself

Abstract

INTRODUCTION AND

aimsNeurological complications such as peripheral neuropathy are very common in the end-stage renal disease (ESRD) patients, occurring in 60-80% of this specific population. The aim of the present study was to examine whether a 9-month hybrid intradialytic exercise training program could alter motor and sensory nerve conduction study (NCS) parameters in hemodialysis population.

methodsSeventeen stable patients undergoing HD with no clinical evidence of uremic polyneuropathy were included in the study (15 M/2F, 59 ± 13.7 years). All patients completed a 9-month supervised exercise training program composed of both aerobic cycling and resistance training (hybrid) during HD. Functional capacity was assessed by a battery of tests, while pain levels and fatigue profile were assessed via validated questionnaires. Motor and sensory NCS on bilateral median, ulnar, peroneal and tibial nerves as well as F-wave were assessed using a full neurographic electromyography (EMG) assessment.

resultsAfter the 9-month exercise training intervention, exercise capacity was increased by 65% and functional capacity by an average of 40%. The neurological assessment showed that conduction velocity from tibial and peroneal nerves was improved by 3.7% and 4.2%, respectively, while tibial F-wave latency and peroneal and sural nerve distal latency were significantly improved by 4.2%, 4.9% and 10%, respectively. Fatigue and pain were improved after the exercise intervention while fatigue score was positively correlated with conduction velocity and amplitude values.

conclusionsThe results of the current study demonstrate that 9-month hybrid exercise training induces beneficial effects on both sensory and motor NCS parameters, improving conduction velocity and F-wave latency. Improvements in neural activity were accompanied by changes in fatigue score and pain-related aspects. The parallel improvement in motor nerve conduction velocity and its correlations with functional tests supports the hypothesis that exercise could be beneficial for preventing a decline in neural function in HD patients.

Indexed as

Neural ConductionRenal DialysisExerciseFatigueHumansPainElectromyographyExerciseFatigueFunctional capacityHemodialysis

Identifiers

PMID35789452
OpenAlexW4283817608

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.