Evidence map›Paper›PMID 35789284›Full record

ArticleClinical neuroradiology2023

Ischemic Lesion Growth in Patients with a Persistent Target Mismatch After Large Vessel Occlusion.

Shinya Tomari, Thomas Lillicrap, Carlos Garcia-Esperon, Yumi Tomari Kashida, Andrew Bivard, Longting Lin, Christopher R Levi, Neil J Spratt

Open access · hybridFull text read
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In one paragraph

Article in Clinical neuroradiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Shinya TomariHunter Medical Research Institute, University of Newcastle, Newcastle, Australia. sny5588@gmail.com.ORCID http://orcid.org/0000-0001-9680-1723
Thomas LillicrapHunter Medical Research Institute, University of Newcastle, Newcastle, Australia.
Carlos Garcia-EsperonHunter Medical Research Institute, University of Newcastle, Newcastle, Australia.
Yumi Tomari KashidaHunter Medical Research Institute, University of Newcastle, Newcastle, Australia.
Andrew BivardMelbourne Brain Center at the Royal Melbourne Hospital, University of Melbourne, Melbourne, Australia.
Longting LinHunter Medical Research Institute, University of Newcastle, Newcastle, Australia.
Christopher R LeviHunter Medical Research Institute, University of Newcastle, Newcastle, Australia.
Neil J SprattHunter Medical Research Institute, University of Newcastle, Newcastle, Australia.
Hunter Medical Research Institute · AUJohn Hunter Hospital · AUThe Royal Melbourne Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFailure to reperfuse a cerebral occlusion resulting in a persistent penumbral pattern has not been fully described.

methodsWe retrospectively reviewed patients with anterior large vessel occlusion who did not receive reperfusion, and underwent repeated perfusion imaging, with baseline imaging < 6 h after onset and follow-up scans from 16-168 h. A persistent target mismatch (PTM) was defined as core volume of < 100 mL, mismatch ratio > 1.2, and mismatch volume > 10 mL on follow-up imaging. Patients were divided into PTM or non-PTM groups. Ischemic core and penumbral volumes were compared between baseline and follow-up imaging between the two groups, and collateral flow status assessed using CT perfusion collateral index.

resultsA total of 25 patients (14 PTM and 11 non-PTM) were enrolled in the study. Median core volumes increased slightly in the PTM group, from 22 to 36 ml. There was a much greater increase in the non-PTM group, from 57 to 190 ml. Penumbral volumes were stable in the PTM group from a median of 79 ml at baseline to 88 ml at follow-up, whereas penumbra was reduced in the non-PTM group, from 120 to 0 ml. Collateral flow status was also better in the PTM group and the median collateral index was 33% compared with 44% in the non-PTM group (p = 0.043).

conclusionMultiple patients were identified with limited core growth and large penumbra (persistent target mismatch) > 16 h after stroke onset, likely due to more favorable collateral flow.

Indexed as

Brain IschemiaStrokeHumansRetrospective StudiesTomography, X-Ray ComputedCT perfusion collateral indexCT perfusion imageGood collateral flowLittle core growthPersistent large penumbra

Identifiers

PMID35789284
PMCPMC10014761
OpenAlexW4283811009

What OpenQuestion holds

Textfull text, public
LicenceCC BY
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.