Evidence map›Paper›PMID 35789165›Full record

ArticleScientific reports2022

Stable isotope analysis confirms substantial changes in the fatty acid composition of bacteria treated with antimicrobial random peptide mixtures (RPMs).

Nina Wiedmaier-Czerny, Dorothee Schroth, Stephanie Krauß, Shiri Topman-Rakover, Aya Brill, Saul Burdman, Zvi Hayouka, Walter Vetter

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In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nina Wiedmaier-CzernyDepartment of Food Chemistry (170B), Institute of Food Chemistry, University of Hohenheim, 70593, Stuttgart, Germany.
Dorothee SchrothDepartment of Food Chemistry (170B), Institute of Food Chemistry, University of Hohenheim, 70593, Stuttgart, Germany.
Stephanie KraußDepartment of Food Chemistry (170B), Institute of Food Chemistry, University of Hohenheim, 70593, Stuttgart, Germany.
Shiri Topman-RakoverInstitute of Biochemistry, Food Science and Nutrition, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, 7610001, Israel.
Aya BrillInstitute of Biochemistry, Food Science and Nutrition, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, 7610001, Israel.
Saul BurdmanDepartment of Plant Pathology and Microbiology, Institute of Environmental Sciences, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, 7610001, Israel.
Zvi HayoukaInstitute of Biochemistry, Food Science and Nutrition, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, 7610001, Israel. zvi.hayouka@mail.huji.ac.il.
Walter VetterDepartment of Food Chemistry (170B), Institute of Food Chemistry, University of Hohenheim, 70593, Stuttgart, Germany. walter.vetter@uni-hohenheim.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Resistance of plant-pathogenic bacteria to classic antibiotics has prompted the search for suitable alternative antimicrobial substances. One promising strategy could be the use of purposely synthesized random peptide mixtures (RPMs). Six plant-pathogenic bacteria were cultivated and treated with two RPMs previously found to show antimicrobial activity mainly by bacterial membrane disruption. Here, we show that bacteria treated with RPMs showed partly remarkable changes in the fatty acid pattern while those unaffected did not. Quantitative changes could be verified by compound specific isotope analysis of δ

Indexed as

Anti-Bacterial AgentsAntimicrobial PeptidesBacteriaFatty AcidsIsotopesAnti-Infective AgentsDrug Resistance, BacterialPeptidesPlant DiseasesPlantsAnti-Bacterial AgentsAnti-Infective AgentsAntimicrobial PeptidesFatty AcidsIsotopesPeptides

Identifiers

PMID35789165
PMCPMC9252987

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.