Evidence map›Paper›PMID 35789021›Full record

ArticleAmerican journal of reproductive immunology (New York, N.Y. : 1989)2022

Decreased severity of COVID-19 in vaccinated pregnant individuals during predominance of different SARS-CoV-2 variants.

Joe Eid, Mahmoud Abdelwahab, Hayley Williams, Madeleine Caplan, Sema Hajmurad, Kartik K Venkatesh, Maged M Costantine, Kara M Rood

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of reproductive immunology (New York, N.Y. : 1989), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. An Update on COVID-19 Vaccination and Pregnancy.Journal of personalized medicine · 2023
    Review
  6. Pregnancy and COVID-19: past, present and future.Obstetrics & gynecology science · 2023
    Article
  7. Review
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Joe EidMaternal Fetal Medicine Division, Department of Obstetrics and Gynecology at The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0001-9366-7100
Mahmoud AbdelwahabMaternal Fetal Medicine Division, Department of Obstetrics and Gynecology at The Ohio State University, Columbus, Ohio, USA.
Hayley WilliamsMaternal Fetal Medicine Division, Department of Obstetrics and Gynecology at The Ohio State University, Columbus, Ohio, USA.
Madeleine CaplanMaternal Fetal Medicine Division, Department of Obstetrics and Gynecology at The Ohio State University, Columbus, Ohio, USA.
Sema HajmuradMaternal Fetal Medicine Division, Department of Obstetrics and Gynecology at The Ohio State University, Columbus, Ohio, USA.
Kartik K VenkateshMaternal Fetal Medicine Division, Department of Obstetrics and Gynecology at The Ohio State University, Columbus, Ohio, USA.
Maged M CostantineMaternal Fetal Medicine Division, Department of Obstetrics and Gynecology at The Ohio State University, Columbus, Ohio, USA.
Kara M RoodMaternal Fetal Medicine Division, Department of Obstetrics and Gynecology at The Ohio State University, Columbus, Ohio, USA.
The Ohio State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

problemSince the start of the pandemic, Pregnant individuals have been disproportionately affected by the severe acute respiratory syndrome coronavirus 2. Vaccination has been shown to be protective against severe disease. However, data on effectiveness of vaccine in reducing disease severity are limited in pregnant individuals who later developed COVID-19. METHOD OF STUDY: This is a single academic center retrospective cohort study of pregnant individuals who tested positive for COVID-19 from December 2020 through January 2022. The cohort was divided into two groups based on vaccination status. The primary outcome of our study was progression to severe or critical disease. A secondary analysis was performed based on the timeframes of predominance of different variants of SARS-CoV-2, to determine whether the effect of vaccination was different during these epochs.

resultsOur cohort included 472 patients among which 125 (26.5%) were vaccinated and 347 were unvaccinated. None of the patients in the vaccinated group who later developed COVID-19 progressed to severe or critical disease compared to 7.2% in the unvaccinated one (p < .01). Similarly, after adjusting for medical comorbidities, obesity, receipt of monoclonal antibodies, and trimester at diagnosis, vaccinated individuals who later developed COVID-19 were less likely to be admitted to the hospital (1.6% vs. 14.7%, aOR .14, 95% CI .22-.47) compared with unvaccinated ones.

conclusionVaccination against SARS-CoV-2 in pregnant individuals who later develop a breakthrough infection, is associated with decreased progression to severe or critical COVID-19, and need for hospital and ICU admissions. Vaccination is specifically effective during the predominance of the more severe Delta variant.

Indexed as

COVID-19Pregnancy Complications, InfectiousViral VaccinesFemaleHumansPregnancyRetrospective StudiesSARS-CoV-2VaccinationViral VaccinesCOVID-19pregnancySARS-CoV-2 variantsvaccination

Identifiers

PMID35789021
PMCPMC9349799
OpenAlexW4283803985

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.