ArticleEuropean journal of nutrition2022
Soy product intake and risk of incident disabling dementia: the JPHC Disabling Dementia Study.
Article in European journal of nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Association of high consumption of soy products with the risk of cognitive impairment and major neurocognitive disorders: a systematic review and dose-response meta-analysis.Frontiers in nutrition · 2025Pooled it
- A scoping review of the health effects of fermented foods in specific human populations and their potential role in precision nutrition: current knowledge and gaps.Frontiers in nutrition · 2025Pooled it
- Nutrition and Healthy Ageing in Asia: A Systematic Review.Nutrients · 2023Pooled it
- Protein Consumption and Cognitive Health in Aging: Associations with Sarcopenia and Dietary Options, a Narrative Review.Nutrients · 2026Review
- Soy Intake During Childhood and/or Adolescence and Adult Breast Cancer: An Examination of the Early Soy Intake Hypothesis.Nutrients · 2026Review
- The Dietary Fiber Intake and the Risk of Disabling Dementia: The JPHC Disabling Dementia Study.Journal of atherosclerosis and thrombosis · 2026Article
- Soy and the gut microbiome: a bi-directional relationship shaping nutrition and health.European journal of nutrition · 2026Review
- Association between food intake frequency and psychological distress following the Great East Japan Earthquake: the Fukushima Health Management Survey FY 2012.BMC nutrition · 2025Article
- Perspective: Isoflavones-Intriguing Molecules but Much Remains to Be Learned about These Soybean Constituents.Advances in nutrition (Bethesda, Md.) · 2025Review
- A Review of the Clinical and Epidemiologic Evidence Relevant to the Impact of Postdiagnosis Isoflavone Intake on Breast Cancer Outcomes.Current nutrition reports · 2025Review
- Exploring the Complex Mechanisms of Isoflavones: From Cell Bioavailability, to Cell Dynamics and Breast Cancer.Phytotherapy research : PTR · 2025Review
- Effectiveness of Flavonoid-Rich Diet in Alleviating Symptoms of Neurodegenerative Diseases.Foods (Basel, Switzerland) · 2024Review
- Traditional and Domestic Cooking Dramatically Reduce Estrogenic Isoflavones in Soy Foods.Foods (Basel, Switzerland) · 2024Article
- Disaggregation of amyloid-beta fibrils via natural metabolites using long timescale replica exchange molecular dynamics simulation studies.Journal of molecular modeling · 2024Article
- Association Between Oral Malodor and Dementia: An 11-Year Follow-Up Study in Japan.Journal of Alzheimer's disease reports · 2024Article
- Lactic Acid Bacteria (LAB) and Neuroprotection, What Is New? An Up-To-Date Systematic Review.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Phytoestrogens and Health Effects.Nutrients · 2023Review
- The health effects of soy: A reference guide for health professionals.Frontiers in nutrition · 2022Review
- Body mass index, weight change in midlife, and dementia incidence: the Japan Public Health Center-based Prospective Study.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe evaluated the association between total soy, soy product (natto, miso and tofu) and isoflavone intake and incident disabling dementia in a Japanese population.
methodsWe conducted a population-based prospective study in 18,991 men and 22,456 women. Intake of soy products and isoflavone was calculated using a validated food frequency questionnaire when participants were 45-74 years old (1995 and 1998). Incident disabling dementia was defined by the daily living disability status related to dementia in the long-term care insurance program of Japan from 2006 to 2016. Multivariate hazard ratios (HRs) and 95% confidence intervals (CIs) of disabling dementia were calculated by quintiles of total soy, individual soy product and isoflavone intake, using Cox proportional hazard regression models.
resultsTotal soy product intake was not associated with disabling dementia risk in both men and women. By individual soy products, natto intake was marginally inversely associated with disabling dementia in women (trend P = 0.050). When we stratified by age, this inverse association was clearer in women aged under 60 years (multivariate HR for the highest versus lowest quintile was 0.78, 95% CI 0.59-1.04, trend P = 0.020 for those aged under 60 years and 0.90, 95% CI 0.77-1.05, trend P = 0.23 for those aged 60 years and older, respectively). Any soy product or isoflavone intake was not associated with disabling dementia risk in men.
conclusionsAlthough total soy product intake was not associated with disabling dementia risk, natto intake may contribute to reducing the risk of disabling dementia in women, especially in those aged under 60 years.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.