ArticleNature biomedical engineering2022
A strain-programmed patch for the healing of diabetic wounds.
Article in Nature biomedical engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
111 citing papers in PubMed.
- Quercetin-derived carbon dots-modified ZIF-8 and M2 macrophage-derived migrasomes-functionalized microenvironment-responsive nanocomposite hydrogel for osteoporotic bone defects regeneration.Bioactive materials · 2027Article
- Contractile hydrogel with NIR-induced spatiotemporally programmed release from core-shell nanoparticles for integrated antibacterial and pro-angiogenic healing.Materials today. Bio · 2026Article
- An ultrasound-switchable hydrogel enables sequential antibacterial and anti-inflammatory therapy for infected diabetic wounds.iScience · 2026Article
- Functionalized bio-patches for intra-abdominal applications.iScience · 2026Review
- Intelligent microneedle patch with cobalt-iron Prussian blue nanozymes for accelerating diabetic wound healingBioactive materials · 2026Article
- Immune-Responsive Bioinks Enable Vision-GuidedAdvanced functional materials · 2026Article
- Thermal-feedback modality switchable hydrogel with thermoelectric self-modulation for stage-adaptive repair of infected diabetic wound.Nature communications · 2026Article
- Multi-Axis Stretchable Zippers for Personalized Wound Healing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Ambient Light-Activatable Luminescent Particle-Embedded Conformal Patch for Photochemical Tissue Bonding and Photobiomodulated Healing.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Macrophage Membrane-Camouflaged Nanozyme Microneedles Restore Immunovascular Homeostasis Through SPP1-ApoE Signaling in Diabetic Wounds.Advanced healthcare materials · 2026Article
- Soft Hypoxia-Adaptive Bioelectronics Integrating PEDOT:PSS/Polydopamine/Enzyme Biocomposites for Closed-Loop Therapeutics of Chronic Wounds.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Polymerized Pro-Estrogen Microneedles via Two Photon Polymerization.Macromolecular rapid communications · 2026Article
- Ready-to-use 3D bioprinted scaffolds from natural materials loaded with patient's PRGF for personalized skin regeneration.iScience · 2026Article
- Machine learning-guided design of mechanoadaptive bioglues for multitissue trauma and first-aid applications.Nature biomedical engineering · 2026Article
- Seta-Inspired Mechano-Intelligent Janus Bandage with Coordinated Adhesion-Contraction for Minimizing Scarring.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Dynamically responsive hydrogel with mechanical stimulation enhances diabetic wound healing via activation of Piezo1-mediated efferocytosis.Bioactive materials · 2026Article
- Spatiotemporal acoustic meta-patches for multifactorial wound treatment.Bioactive materials · 2026Article
- Active protein-capturing hydrogel for broad-spectrum pathogen defense.Science advances · 2026Article
- Enalaprilat reverses neutrophil polarization imbalance via targeting taurine-STING axis for treatment of diabetic wounds.Cell reports. Medicine · 2026Article
- A Multifunctional ε-Polylysine/Hyaluronic Acid Hydrogel Promotes Diabetic Wound Healing by Orchestrating Multidimensional Synergy.Pharmaceutics · 2026Article
51 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
20 authors.
Funding
Abstract
Diabetic foot ulcers and other chronic wounds with impaired healing can be treated with bioengineered skin or with growth factors. However, most patients do not benefit from these treatments. Here we report the development and preclinical therapeutic performance of a strain-programmed patch that rapidly and robustly adheres to diabetic wounds, and promotes wound closure and re-epithelialization. The patch consists of a dried adhesive layer of crosslinked polymer networks bound to a pre-stretched hydrophilic elastomer backing, and implements a hydration-based shape-memory mechanism to mechanically contract diabetic wounds in a programmable manner on the basis of analytical and finite-element modelling. In mouse and human skin, and in mini-pigs and humanized mice, the patch enhanced the healing of diabetic wounds by promoting faster re-epithelialization and angiogenesis, and the enrichment of fibroblast populations with a pro-regenerative phenotype. Strain-programmed patches might also be effective for the treatment of other forms of acute and chronic wounds.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.