Evidence map›Paper›PMID 35788685›Full record

ReviewNature biomedical engineering2022

Shifting machine learning for healthcare from development to deployment and from models to data.

Angela Zhang, Lei Xing, James Zou, Joseph C Wu

Abstract readReview
In one paragraph

Review in Nature biomedical engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 165 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
165citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

165 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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105 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Angela ZhangStanford Cardiovascular Institute, School of Medicine, Stanford University, Stanford, CA, USA. angelazhang@greenstonebio.com.ORCID http://orcid.org/0000-0003-0906-6770
Lei XingDepartment of Radiation Oncology, School of Medicine, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-2536-5359
James ZouDepartment of Computer Science, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-8880-4764
Joseph C WuStanford Cardiovascular Institute, School of Medicine, Stanford University, Stanford, CA, USA. joewu@stanford.edu.ORCID http://orcid.org/0000-0002-6068-8041

Funding

Project 3 (Mercola)P01HL141084 · NHLBI · STANFORD UNIVERSITY · PI Joseph C. Wu · 2019 to 2026
$21.1M
Role of Single Cell mRNA Variation in Systems Associated Electrically Excitable CU01MH098953 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI EBERWINE, JAMES H, KIM, JUNHYONG · 2012 to 2016
$11.4M
Elucidating Mechanism of Cardiac Fibrosis with Cell Village of Pooled Human iPSCsR01HL130020 · NHLBI · STANFORD UNIVERSITY · PI Ronglih Liao, MARK MERCOLA · 2016 to 2026
$7.3M
Genome Editing of Human iPSCs to Study Inherited Hypertrophic CardiomyopathyR01HL126527 · NHLBI · STANFORD UNIVERSITY · PI QI, LEI STANLEY, WU, JOSEPH C. · 2015 to 2022
$5.4M
Human iPSC Model to Elucidate Metabolic Interplay in Diabetic CardimyopathyR01HL146690 · NHLBI · STANFORD UNIVERSITY · PI LIAO, RONGLIH, MERCOLA, MARK · 2019 to 2025
$5.1M
Stanford Medicine Center for Longevity and Healthy Aging Research Education CoreP30AG059307 · NIA · STANFORD UNIVERSITY · PI PERIYAKOIL, VYJEYANTHI S, YESAVAGE, JEROME A · 2018 to 2025
$4.9M
Dual Modality X-ray Luminescence CT for in vivo Cancer ImagingR01CA227713 · NCI · STANFORD UNIVERSITY · PI XING, LEI · 2019 to 2023
$2.9M
Elucidating ECM Signaling in Cardiac Organoids with Machine Learning and Single-cell MultiomicsR01HL163680 · NHLBI · STANFORD UNIVERSITY · PI RAJADAS, JAYAKUMAR, WONG, WING H. · 2022 to 2025
$2.5M
Leveraging deep learning for markerless motion management in radiation therapyR01CA256890 · NCI · STANFORD UNIVERSITY · PI XING, LEI · 2021 to 2025
$2.1M
Using Deep Learning to Predict Induced Pluripotent Stem Cell-Derived Cardiomyocyte (iPSC-CM) Differentiation OutcomesF30HL156478 · NHLBI · STANFORD UNIVERSITY · PI ZHANG, ANGELA · 2021 to 2023
$118k
NCI NIH HHS R01 CA227713NCI NIH HHS R01 CA256890NHLBI NIH HHS F30 HL156478NHLBI NIH HHS P01 HL141084NHLBI NIH HHS R01 HL126527NHLBI NIH HHS R01 HL130020NHLBI NIH HHS R01 HL146690NHLBI NIH HHS R01 HL163680NIA NIH HHS P30 AG059307NIMH NIH HHS U01 MH098953
6 · The paper itself

Abstract

In the past decade, the application of machine learning (ML) to healthcare has helped drive the automation of physician tasks as well as enhancements in clinical capabilities and access to care. This progress has emphasized that, from model development to model deployment, data play central roles. In this Review, we provide a data-centric view of the innovations and challenges that are defining ML for healthcare. We discuss deep generative models and federated learning as strategies to augment datasets for improved model performance, as well as the use of the more recent transformer models for handling larger datasets and enhancing the modelling of clinical text. We also discuss data-focused problems in the deployment of ML, emphasizing the need to efficiently deliver data to ML models for timely clinical predictions and to account for natural data shifts that can deteriorate model performance.

Indexed as

Electric Power SuppliesMachine LearningDelivery of Health Care

Identifiers

PMID35788685
PMCPMC12063568

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.