Evidence map›Paper›PMID 35788623›Full record

ArticleScientific reports2022

The iodide transporter Slc26a7 impacts thyroid function more strongly than Slc26a4 in mice.

Naoya Yamaguchi, Atsushi Suzuki, Aya Yoshida, Tatsushi Tanaka, Kohei Aoyama, Hisashi Oishi, Yuichiro Hara, Tomoo Ogi, Izuki Amano, Satomi Kameo and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Thyroid differentiation profile for differentiated thyroid cancer.Endocrine oncology (Bristol, England) · 2025
    Article
  5. Review
  6. SLC26 Anion Transporters.Handbook of experimental pharmacology · 2024
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 1 country.

Naoya Yamaguchi *Department of Pediatrics and Neonatology, Nagoya City University Graduate School of Medical Sciences, 1-Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601, Japan.
Atsushi Suzuki *Department of Pediatrics and Neonatology, Nagoya City University Graduate School of Medical Sciences, 1-Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601, Japan.
Aya YoshidaDepartment of Pediatrics and Neonatology, Nagoya City University Graduate School of Medical Sciences, 1-Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601, Japan.
Tatsushi TanakaDepartment of Pediatrics, Toyohashi Municipal Hospital, Toyohashi, Japan.
Kohei AoyamaDepartment of Pediatrics and Neonatology, Nagoya City University Graduate School of Medical Sciences, 1-Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601, Japan. kohei-a@med.nagoya-cu.ac.jp.
Hisashi OishiDepartment of Comparative and Experimental Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Yuichiro HaraDepartment of Genetics, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.
Tomoo OgiDepartment of Genetics, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.
Izuki AmanoDepartment of Integrative Physiology, Gunma University Graduate School of Medicine, Maebashi, Japan.
Satomi KameoDepartment of Nutrition, Koshien University, Takarazuka, Japan.
Noriyuki KoibuchiDepartment of Integrative Physiology, Gunma University Graduate School of Medicine, Maebashi, Japan.
Yasuhiro ShibataDepartment of Anatomy and Neuroscience, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Shinya UgawaDepartment of Anatomy and Neuroscience, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Haruo MizunoDepartment of Pediatrics, Fujita Health University School of Medicine, Toyoake, Japan.
Shinji SaitohDepartment of Pediatrics and Neonatology, Nagoya City University Graduate School of Medical Sciences, 1-Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601, Japan.
Nagoya City University · JPGunma University · JPNagoya University · JPFujita Health University · JPTakara (Japan) · JPToyohashi Municipal Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

SLC26A4 is a known iodide transporter, and is localized at the apical membrane of thyrocytes. Previously, we reported that SLC26A7 is also involved in iodide transport and that Slc26a7 is a novel causative gene for congenital hypothyroidism. However, its detailed role in vivo remains to be elucidated. We generated mice that were deficient in Slc26a7 and Slc26a4 to delineate differences and associations in their roles in iodide transport. Slc26a7

Indexed as

Congenital HypothyroidismIodineAnimalsChloride-Bicarbonate AntiportersIodidesMembrane Transport ProteinsMiceSulfate TransportersChloride-Bicarbonate AntiportersIodidesIodineMembrane Transport ProteinsSlc26a4 protein, mouseSlc26a7 protein, mouseSulfate Transporters

Identifiers

PMID35788623
PMCPMC9253019
OpenAlexW4283800945

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.