Evidence map›Paper›PMID 35788594›Full record

ArticleNature communications2022

Flexible ultrasound-induced retinal stimulating piezo-arrays for biomimetic visual prostheses.

Laiming Jiang, Gengxi Lu, Yushun Zeng, Yizhe Sun, Haochen Kang, James Burford, Chen Gong, Mark S Humayun, Yong Chen, Qifa Zhou

Abstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed.

  1. Review
  2. Bioinspired Photodetectors: From Nature to Advanced Applications.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
  3. Review
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  5. Article
  6. Article
  7. Autonomous Implants.Advanced materials (Deerfield Beach, Fla.) · 2025
    Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Emerging Wearable Acoustic Sensing Technologies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  15. Article
  16. High-Frequency Wearable Ultrasound Array Belt for Small Animal Echocardiography.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2024
    Article
  17. Sonogenetics in the Treatment of Chronic Diseases: A New Method for Cell Regulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  18. Article
  19. Article
  20. Advanced Ultrasound Energy Transfer Technologies using Metamaterial Structures.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Laiming Jiang *Roski Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA. laiming_jiang@foxmail.com.ORCID http://orcid.org/0000-0002-8658-3168
Gengxi Lu *Roski Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.ORCID http://orcid.org/0000-0001-7497-050X
Yushun Zeng *Roski Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.ORCID http://orcid.org/0000-0001-5995-4085
Yizhe SunDepartment of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, 90089, USA.ORCID http://orcid.org/0000-0001-9291-0076
Haochen KangDepartment of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, 90089, USA.
James BurfordRoski Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
Chen GongRoski Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
Mark S HumayunRoski Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
Yong ChenEpstein Department of Industrial and Systems Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, 90089, USA. yongchen@usc.edu.ORCID http://orcid.org/0000-0002-8377-5914
Qifa ZhouRoski Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA. qifazhou@usc.edu.ORCID http://orcid.org/0000-0003-1527-3020

Funding

Non-invasive Ultrasound Stimulated Retinal ProsthesisR01EY030126 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ZHOU, QIFA · 2019 to 2022
$2.0M
NEI NIH HHS R01 EY030126
6 · The paper itself

Abstract

Electronic visual prostheses, or biomimetic eyes, have shown the feasibility of restoring functional vision in the blind through electrical pulses to initiate neural responses artificially. However, existing visual prostheses predominantly use wired connections or electromagnetic waves for powering and data telemetry, which raises safety concerns or couples inefficiently to miniaturized implant units. Here, we present a flexible ultrasound-induced retinal stimulating piezo-array that can offer an alternative wireless artificial retinal prosthesis approach for evoking visual percepts in blind individuals. The device integrates a two-dimensional piezo-array with 32-pixel stimulating electrodes in a flexible printed circuit board. Each piezo-element can be ultrasonically and individually activated, thus, spatially reconfigurable electronic patterns can be dynamically applied via programmable ultrasound beamlines. As a proof of concept, we demonstrate the ultrasound-induced pattern reconstruction in ex vivo murine retinal tissue, showing the potential of this approach to restore functional, life-enhancing vision in people living with blindness.

Indexed as

Visual ProsthesisAnimalsBiomimeticsBlindnessHumansMiceRetinaVision, Ocular

Identifiers

PMID35788594
PMCPMC9253314

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.