ArticleJournal of experimental botany2022
A weak allele of OsNRAMP5 confers moderate cadmium uptake while avoiding manganese deficiency in rice.
Article in Journal of experimental botany, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 28 citations in OpenAlex.
- The Tartary Buckwheat FtMYB46-FtNRAMP3 Module Enhances Plant Lead and Cadmium Tolerance.Plant, cell & environment · 2026Article
- Rice EMF3 Alleles Adjust Flower Opening Time to Enhance the Seed Setting Rate Under High Temperature Stress.Plant biotechnology journal · 2026Article
- Molecular insights into cadmium transport and micronutrient crosstalk in rice: Towards minimizing grain Cd.Journal of integrative plant biology · 2026Review
- Molecular Evolution and Mechanisms of Plants NRAMP Transporters in Response to Heavy Metal Stress.Plants (Basel, Switzerland) · 2026Review
- Pyramiding elite alleles of the genetically linked OsNRAMP5 and OsHMA3 confers low Cd accumulation in rice grains without compromising stress tolerance.Plant communications · 2026Article
- Functional characterization of SmNRAMP1 allelic variants conferring reduced cadmium uptake in Salvia miltiorrhiza.BMC plant biology · 2026Article
- A Review of Reducing Cadmium Pollution in the Rice-Soil System in China.Foods (Basel, Switzerland) · 2025Review
- Uptake and Accumulation of Cobalt Is Mediated by OsNramp5 in Rice.Plant, cell & environment · 2025Article
- Breeding of a promising isogenic line of rice (Breeding science · 2024Article
- Production of grains with ultra-low heavy metal accumulation by pyramiding novel Alleles of OsNramp5 and OsLsi2 in two-line hybrid rice.Plant biotechnology journal · 2024Article
- Multiomics and biotechnologies for understanding and influencing cadmium accumulation and stress response in plants.Plant biotechnology journal · 2024Review
- Engineering rice Nramp5 modifies cadmium and manganese uptake selectivity using yeast assay system.Frontiers in plant science · 2024Article
- Amino Acid Residues of the Metal Transporter OsNRAMP5 Responsible for Cadmium Absorption in Rice.Plants (Basel, Switzerland) · 2023Article
- A weak allele of OsNRAMP5 for safer rice.Journal of experimental botany · 2022Article
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5 authors at 2 institutions in 1 country.
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Abstract
Decreasing cadmium (Cd) concentrations in rice grains can effectively reduce potential risks to human health because rice is the major contributor to Cd intake in many diets. Among several genes involved in rice Cd accumulation, the loss of function of OsNRAMP5 is known to be effective in reducing grain concentration by inhibiting root uptake. However, disruption of this gene simultaneously decreases manganese (Mn) uptake because OsNRAMP5 is a major Mn transporter. With the aim of improving Mn uptake in OsNRAMP5 mutants while still restricting the grain Cd concentration below the upper limit of international standards, we identified a novel OsNRAMP5 allele encoding a protein in which glutamine (Q) at position 337 was replaced by lysine (K). The mutant carrying the OsNRAMP5-Q337K allele showed intermediate Cd and Mn accumulation between that of the wild-type and OsNRAMP5-knockout lines, and exhibited more resistance to Mn deficiency than the knockout lines. Different amino acid substitutions at position Q337 significantly affected the Cd and Mn transport activity in yeast cells, indicating that it is one of the crucial sites for OsNRAMP5 function. Our results suggest that the OsNRAMP5-Q337K allele might be useful for reducing grain Cd concentrations without causing severe Mn deficiency in rice cultivars through DNA marker-assisted breeding.
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