ArticleGenome biology2022
Combined nature and human selections reshaped peach fruit metabolome.
Article in Genome biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 76 citations in OpenAlex.
- Genome-wide association studies in horticultural crops: decoding genetic diversity for precision breeding.Horticulture research · 2026Article
- Identification of QTLs linked to bioactive flavonoids and glycosides in the apricot fruit (Prunus armeniaca L.).BMC genomics · 2026Article
- Whole-Genome Resequencing ofInternational journal of molecular sciences · 2026Article
- The Influence of Pre-Harvest Application ofFoods (Basel, Switzerland) · 2026Article
- The C2H2-GGAT Regulatory Module Fine-Tunes Glutamate Homeostasis to Improve Fruit Flavour and Enhance Disease Resistance in Peach.Plant biotechnology journal · 2026Article
- Analysis of mechanisms underlying accelerated plant growth induced by NtGLK85 overexpression in tobacco.Scientific reports · 2025Article
- Marker Metabolite-Based Multi-Omics Analysis Identifies New Loci Controlling Thousand Seed Weight in Brassica Napus.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- The genomic design of fruit metabolomes.Plant communications · 2025Review
- Optimized Auxin and Cytokinin Interactions Enable Direct Somatic Embryogenesis in the Peach Rootstock 'GuardianInternational journal of molecular sciences · 2025Article
- Genetic architecture of key traits forHorticulture research · 2025Article
- A reproducible ddRAD-seq protocol reveals novel genomic association signatures for fruit-related traits in peach.Plant methods · 2025Article
- Integrating whole-genome resequencing and machine learning to refine QTL analysis for fruit quality traits in peach.Horticulture research · 2025Article
- Occurrence of White Flesh Color and Refreshing Flavor FollowingJournal of agricultural and food chemistry · 2025Article
- Graph pangenome reveals the regulation of malate content in blood-fleshed peach by NAC transcription factors.Genome biology · 2025Article
- Novel Targets for Fruit Conservation Strategies Revealed by Omics Studies: A Systematic Review and Meta-Analysis.International journal of food science · 2025Review
- Soluble sugar, organic acid and phenolic composition and flavor evaluation of plum fruits.Food chemistry: X · 2024Article
- Evolution of plant metabolism: the state-of-the-art.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Multi-Omics Analysis Uncovers the Mechanism for Enhanced Organic Acid Accumulation in Peach (Plants (Basel, Switzerland) · 2024Article
- PCMD: A multilevel comparison database of intra- and cross-species metabolic profiling in 530 plant species.Plant communications · 2024Article
- Integrative multi-omics analysis reveals genetic and heterotic contributions to male fertility and yield in potato.Nature communications · 2024Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPlant metabolites reshaped by nature and human beings are crucial for both their lives and human health. However, which metabolites respond most strongly to selection pressure at different evolutionary stages and what roles they undertake on perennial fruit crops such as peach remain unclear.
resultsHere, we report 18,052 significant locus-trait associations, 12,691 expression-metabolite correlations, and 294,676 expression quantitative trait loci (eQTLs) for peach. Our results indicate that amino acids accumulated in landraces may be involved in the environmental adaptation of peaches by responding to low temperature and drought. Moreover, the contents of flavonoids, the major nutrients in fruits, have kept decreasing accompanied by the reduced bitter flavor during both domestication and improvement stages. However, citric acid, under the selection of breeders' and consumers' preference for flavor, shows significantly different levels between eastern and western varieties. This correlates with differences in activity against cancer cells in vitro in fruit from these two regions. Based on the identified key genes regulating flavonoid and acid contents, we propose that more precise and targeted breeding technologies should be designed to improve peach varieties with rich functional contents because of the linkage of genes related to bitterness and acid taste, antioxidant and potential anti-cancer activity that are all located at the top of chromosome 5.
conclusionsThis study provides powerful data for future improvement of peach flavor, nutrition, and resistance in future and expands our understanding of the effects of natural and artificial selection on metabolites.
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