Evidence map›Paper›PMID 35788155›Full record

ArticleJournal of neurophysiology2022

The potassium channel auxiliary subunit Kvβ2 (

Joshua X Yee, Ariana Rastani, Marta E Soden

Open access · greenAbstract read
In one paragraph

Article in Journal of neurophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Article
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  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Joshua X YeeDepartment of Pharmacology, University of Washington, Seattle, Washington.ORCID 0000-0002-3661-2071
Ariana RastaniDepartment of Pharmacology, University of Washington, Seattle, Washington.
Marta E SodenDepartment of Pharmacology, University of Washington, Seattle, Washington.ORCID 0000-0002-0695-8653
University of Washington · US

Funding

University of Washington Center of Excellence in Opioid Addiction ResearchP30DA048736 · NIDA · UNIVERSITY OF WASHINGTON · PI Charles Chavkin · 2019 to 2026
$13.0M
Leica SP8 WWL Confocal MicroscopeS10OD016240 · OD · UNIVERSITY OF WASHINGTON · PI CATTERALL, WILLIAM A · 2014 to 2014
$581k
Targeted mutagenesis to elucidate the function of understudied ion channels in the central nervous systemR03TR003307 · NCATS · UNIVERSITY OF WASHINGTON · PI SODEN, MARTA E · 2020 to 2020
$156k
NCATS NIH HHS R03 TR003307NIDA NIH HHS P30 DA048736NIH HHS S10 OD016240
6 · The paper itself

Abstract

Ion channel complexes typically consist of both pore-forming subunits and auxiliary subunits that do not directly conduct current but can regulate trafficking or alter channel properties. Isolating the role of these auxiliary subunits in neurons has proved difficult due to a lack of specific pharmacological agents and the potential for developmental compensation in constitutive knockout models. Here, we use cell-type-specific viral-mediated CRISPR/Cas9 mutagenesis to target the potassium channel auxiliary subunit Kvβ2 (

Indexed as

Dopaminergic NeuronsPotassium ChannelsAnimalsMiceShaker Superfamily of Potassium ChannelsKcnab2 protein, mousePotassium ChannelsShaker Superfamily of Potassium ChannelsCRISPRdopamineKvβ2potassium channel

Identifiers

PMID35788155
PMCPMC9273274
OpenAlexW4282922335

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.