Evidence map›Paper›PMID 35788152›Full record

ReviewAmerican journal of physiology. Gastrointestinal and liver physiology2022

Distension contraction plots of pharyngeal/esophageal peristalsis: next frontier in the assessment of esophageal motor function.

Taher I Omari, Ali Zifan, Charles Cock, Ravinder K Mittal

2 registry-linked trialsOpen access · greenAbstract readReview
In one paragraph

Review in American journal of physiology. Gastrointestinal and liver physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06665971 phase4recruitingnot on this mapstarted 2024, after this paper: background citation

Effect of Dupilumab on Esophageal Peristaltic Function in Participants with Eosinophilic Esophagitis

TypeinterventionalSponsorUniversity of California, San DiegoRan2024 to 2026Enrolled30ConditionsEosinophilic Esophagitis (EoE)ArmsDupilumab 300 MG/2 ML Subcutaneous Solution [DUPIXENT]
NCT06883175 narecruitingnot on this mapstarted 2024, after this paper: background citation

Evolution of the Chicago Classification: Bridging Physiology and Mechanics

TypeinterventionalSponsorNorthwestern UniversityRan2024 to 2029Enrolled575ConditionsDysphagia, Achalasia, Esophageal, Ineffective Esophageal MotilityArmsFLIP, HRM, Prucalopride
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. A review of recent developments in the imaging of disorders of gut-brain interaction.Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi · 2025
    Review
  7. Phrenic Ampulla Emptying Dysfunction in Patients with Esophageal Symptoms.Journal of neurogastroenterology and motility · 2024
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Taher I OmariFlinders Health and Medical Research Institute and College of Medicine and Public Health, Flinders University, Adelaide, Australia.
Ali ZifanDivision of Gastroenterology, Department of Medicine, University of California, San Diego, California.ORCID 0000-0003-0272-7492
Charles CockDepartment of Gastroenterology and Hepatology, Flinders Medical Centre, Southern Adelaide Local Health Network, Adelaide, Australia.ORCID 0000-0003-3578-1137
Ravinder K MittalDivision of Gastroenterology, Department of Medicine, University of California, San Diego, California.ORCID 0000-0001-5228-9617
University of California San Diego · USFlinders Medical Centre · AUFlinders University · AU

Funding

Novel Electrical Impedance Methodology to Understand Functional DysphagiaR01DK109376 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MITTAL, RAVINDER K. · 2016 to 2020
$2.5M
NIDDK NIH HHS R01 DK109376
6 · The paper itself

Abstract

Esophageal peristalsis consists of initial inhibition (relaxation) followed by excitation (contraction), both of which move sequentially in the aboral direction. Initial inhibition results in receptive relaxation and bolus-induced luminal distension, which allows propulsion by the contraction with minimal resistance to flow. Similar to the contraction wave, luminal distension has unique waveform characteristics in normal subjects; both are modulated by bolus volume, bolus viscosity, and posture, suggesting a possible cause-and-effect relationship between the two. Distension contraction plots in patients with dysphagia with normal bolus clearance [high-amplitude esophageal contractions (HAECs), esophagogastric junction outflow obstruction (EGJOO), and functional dysphagia (FD)] reveal two major findings:

Indexed as

Deglutition DisordersEsophageal Motility DisordersUrinary Bladder DiseasesHumansManometryPeristalsiscontractiondistensionesophageal manometryesophageal peristalsismotility disorders

Identifiers

PMID35788152
PMCPMC9377784
OpenAlexW4283829730

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.