Evidence map›Paper›PMID 35787772›Full record

ArticleBMC genomics2022

Equus roundworms (Parascaris univalens) are undergoing rapid divergence while genes involved in metabolic as well as anthelminic resistance are under positive selection.

Lei Han, Tianming Lan, Yaxian Lu, Mengchao Zhou, Haimeng Li, Haorong Lu, Qing Wang, Xiuyun Li, Shan Du, Chunyu Guan and 11 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 8 institutions in 1 country.

Lei Han *College of Wildlife and Protected Area, Northeast Forestry University, Harbin, 150040, China.
Tianming Lan *BGI Life Science Joint Research Center, Northeast Forestry University, Harbin, China. lantianming@genomics.cn.
Yaxian Lu *College of Wildlife and Protected Area, Northeast Forestry University, Harbin, 150040, China.
Mengchao ZhouCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin, 150040, China.
Haimeng LiState Key Laboratory of Agricultural Genomics, BGI-Shenzhen, Shenzhen, 518083, China.
Haorong LuGuangdong Provincial Key Laboratory of Genome Read and Write, BGI-Shenzhen, Shenzhen, 518120, China.
Qing WangState Key Laboratory of Agricultural Genomics, BGI-Shenzhen, Shenzhen, 518083, China.
Xiuyun LiHarbin Northern Forest Zoo, Harbin, 150040, China.
Shan DuInner Mongolia Agriculture University, Hohhot, 010000, China.
Chunyu GuanHarbin Northern Forest Zoo, Harbin, 150040, China.
Yong ZhangCenter for Animal Disease Control and Prevention of Ordos, Inner Mongolia Ordos, 017000, China.
Sunil Kumar SahuState Key Laboratory of Agricultural Genomics, BGI-Shenzhen, Shenzhen, 518083, China.
Puyi QianGuangdong Provincial Key Laboratory of Genome Read and Write, BGI-Shenzhen, Shenzhen, 518120, China.
Shaofang ZhangGuangdong Provincial Key Laboratory of Genome Read and Write, BGI-Shenzhen, Shenzhen, 518120, China.
Hongcheng ZhouGuangdong Provincial Key Laboratory of Genome Read and Write, BGI-Shenzhen, Shenzhen, 518120, China.
Wei GuoState Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150040, China.
Hongliang ChaiCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin, 150040, China.
Sibo WangState Key Laboratory of Agricultural Genomics, BGI-Shenzhen, Shenzhen, 518083, China.
Quan LiuCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin, 150040, China. liuquan1973@hotmail.com.
Huan LiuBGI Life Science Joint Research Center, Northeast Forestry University, Harbin, China. liuhuan@genomics.cn.
Zhijun HouCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin, 150040, China. houzhijundb@163.com.
Northeast Forestry University · CNBGI Group (China) · CNChina National GeneBank · CNState Forestry and Grassland Administration · CNUniversity of Chinese Academy of Sciences · CNHarbin Veterinary Research Institute · CNInner Mongolia Agricultural University · CNInner Mongolia Comprehensive Disease Prevention and Control Center · CN

Funding

Forestry science and technology research project No. 20180302Fundamental Research Funds for the Central Universities of China No. 2572020AA30Open Project of Key Laboratory of SFGA on Conservation Biology of Rare Animals in The Giant Panda National Park No.2020004the Foundation of Key Laboratory of State Forestry and Grassland Administration (State Park Administration) on Conservation Biology of Rare Animals in the Giant Panda National Park No. KLSFGAGP2020.002the Fundamental Research Funds for the Central Universities of China 2572020AW30the Guangdong Provincial Key Laboratory of Genome Read and Write No. 2017B030301011the National Key R&D Program No. 2017YFD0501702the Pearl River Talent Recruitment Program in Guangdong Province 2019CX01N111
6 · The paper itself

Abstract

backgroundThe evolution of parasites is often directly affected by the host's environment. Studies on the evolution of the same parasites in different hosts are of great interest and are highly relevant to our understanding of divergence.

methodsHere we performed whole-genome sequencing of Parascaris univalens from different Equus hosts (horses, zebras and donkeys). Phylogenetic and selection analyses were performed to study the divergence and adaptability of P. univalens.

resultsAt the genetic level, multiple lines of evidence indicate that P. univalens is mainly separated into two clades (horse-derived and zebra & donkey-derived). This divergence began 300-1000 years ago, and we found that most of the key enzymes related to glycolysis were under strong positive selection in zebra & donkey-derived roundworms, whereas the lipid-related metabolic system was under positive selection in horse-derived roundworms, indicating that the adaptive evolution of metabolism has occurred over the past few centuries. In addition, we found that some drug-related genes showed a significantly higher degree of selection in diverse populations.

conclusionsThis work reports the adaptive evolution and divergence trend of P. univalens in different hosts for the first time. Its results indicate that the divergence of P. univalens is a continuous, dynamic process. Furthermore, the continuous monitoring of the effects of differences in nutritional and drug histories on the rapid evolution of roundworms is conducive to further understanding host-parasite interactions.

Indexed as

AscaridoideaParasitesAnimalsEquidaeHorsesPhylogenyAdaptationDiversificationEvolutionParascaris univalens

Identifiers

PMID35787772
PMCPMC9252044
OpenAlexW4283805366

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.