Increased spine PIP3 is sequestered from dendritic shafts.

Yoshibumi Ueda, Naotoshi Sugimoto, Takeaki Ozawa

Open access · goldAbstract read

In one paragraph

Article in Molecular brain, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact, top 93% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Yoshibumi UedaDepartment of Chemistry, School of Science, The University of Tokyo, Tokyo, Japan. yoshibumiueda@gmail.com.ORCID 0000-0003-1500-3469

Naotoshi SugimotoDepartment of Physiology, Graduate School of Medical Science, Kanazawa University, Ishikawa, Japan.

Takeaki OzawaDepartment of Chemistry, School of Science, The University of Tokyo, Tokyo, Japan. ozawa@chem.s.u-tokyo.ac.jp.

Kanazawa University · JPThe University of Tokyo · JPTokyo University of Science · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phosphatidylinositol 3,4,5-trisphosphate (PIP3) is a lipid second messenger that is crucial for the synaptic plasticity underlying learning and memory in pyramidal neurons in the brain. Our previous study uncovered PIP3 enrichment in the dendritic spines of hippocampal pyramidal neurons in the static state using a fluorescence lifetime-based PIP3 probe. However, the extent to which PIP3 enrichment is preserved in different states has not been fully investigated. Here, we revealed that PIP3 accumulation in dendritic spines is strictly controlled even in an active state in which PIP3 is increased by glutamate stimulation and high potassium-induced membrane depolarization. Time-course PIP3 analysis clarified the gradual PIP3 accumulation in dendritic spines over days during neuronal development. Collectively, these results deepen our understanding of PIP3 dynamics in dendritic spines, and the dysregulation of the PIP3 gradient between dendritic spines and shafts could cause neuronal diseases and mental disorders, such as autism spectrum disorder.

Indexed as

Autism Spectrum DisorderFluorescent DyesGlutamic AcidHumansNeuronal PlasticityPyramidal CellsSpineFluorescent DyesGlutamic AcidDendritic spineFluorescence lifetimeFluorescence resonance energy transferHippocampusPhosphatidylinositol 3,4,5-trisphosphateTwo-photon microscopy

Identifiers

PMID35787719

DOI10.1186/s13041-022-00944-5

PMCPMC9254409

OpenAlexW4283793842

What OpenQuestion holds

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.