Evidence map›Paper›PMID 35787306›Full record

ArticleActa neuropathologica communications2022

Increased CSF-decorin predicts brain pathological changes driven by Alzheimer's Aβ amyloidosis.

Richeng Jiang, Una Smailovic, Hazal Haytural, Betty M Tijms, Hao Li, Robert Mihai Haret, Ganna Shevchenko, Gefei Chen, Axel Abelein, Johan Gobom and 15 more

Open access · goldAbstract read
In one paragraph

Article in Acta neuropathologica communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 9 institutions in 6 countries.

Richeng JiangDepartment of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, 171 64, Stockholm, Sweden. richeng.jiang@ki.se.ORCID 0000-0001-5184-4172
Una SmailovicDepartment of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Clinical Geriatrics, Karolinska Institutet, 141 52, Huddinge, Sweden.
Hazal HayturalDepartment of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, 171 64, Stockholm, Sweden.
Betty M TijmsAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, 1007 MB, Amsterdam, The Netherlands.
Hao LiDepartment of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, 171 64, Stockholm, Sweden.
Robert Mihai HaretDivision of Physiology and Neuroscience, Carol Davila University of Medicine and Pharmacy, 050474, Bucharest, Romania.
Ganna ShevchenkoDepartment of Chemistry - BMC, Analytical Chemistry and Neurochemistry, Uppsala University, 752 37, Uppsala, Sweden.
Gefei ChenDepartment of Biosciences and Nutrition, Karolinska Institutet, 141 52, Huddinge, Sweden.
Axel AbeleinDepartment of Biosciences and Nutrition, Karolinska Institutet, 141 52, Huddinge, Sweden.
Johan GobomDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, 413 45, Mölndal, Sweden.
Susanne FrykmanDepartment of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, 171 64, Stockholm, Sweden.
Misaki SekiguchiLaboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Wako, Saitama, 351-0198, Japan.
Ryo FujiokaLaboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Wako, Saitama, 351-0198, Japan.
Naoto WatamuraLaboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Wako, Saitama, 351-0198, Japan.
Hiroki SasaguriLaboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Wako, Saitama, 351-0198, Japan.
Sofie NyströmIFM-Department of Physics, Chemistry and Biology, Linköping University, 581 83, Linköping, Sweden.
Per HammarströmIFM-Department of Physics, Chemistry and Biology, Linköping University, 581 83, Linköping, Sweden.
Takaomi C SaidoLaboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Wako, Saitama, 351-0198, Japan.
Vesna JelicDepartment of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Clinical Geriatrics, Karolinska Institutet, 141 52, Huddinge, Sweden.
Stina SyvänenMolecular Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, 751 85, Uppsala, Sweden.
Henrik ZetterbergDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, 413 45, Mölndal, Sweden.
Bengt WinbladDepartment of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, 171 64, Stockholm, Sweden.
Jonas BergquistDepartment of Chemistry - BMC, Analytical Chemistry and Neurochemistry, Uppsala University, 752 37, Uppsala, Sweden.
Pieter Jelle VisserDepartment of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, 171 64, Stockholm, Sweden.
Per NilssonDepartment of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, 171 64, Stockholm, Sweden. Per.et.Nilsson@ki.se.ORCID 0000-0001-6450-0870
Karolinska Institutet · SERIKEN Center for Brain Science · JPUppsala University · SEKarolinska University Hospital · SELinköping University · SESahlgrenska University Hospital · SEAmsterdam Neuroscience · NLCarol Davila University of Medicine and Pharmacy · ROJilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cerebrospinal fluid (CSF) biomarkers play an important role in diagnosing Alzheimer's disease (AD) which is characterized by amyloid-β (Aβ) amyloidosis. Here, we used two App knock-in mouse models, App

Indexed as

Alzheimer DiseaseAmyloidosisAmyloid beta-PeptidesAnimalsBrainDecorinHumansMicePlaque, AmyloidProteomeAmyloid beta-PeptidesDecorinProteomeAlzheimer’s diseaseAmyloid-β (Aβ)App knock-in miceAutophagyCerebrospinal fluidChoroid plexusDecorinExtracellular matrixMass spectrometry

Identifiers

PMID35787306
PMCPMC9254429
OpenAlexW4283794765

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.