Evidence map›Paper›PMID 35787055›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

A long noncoding RNA influences the choice of the X chromosome to be inactivated.

Andreas Hierholzer, Corinne Chureau, Alessandra Liverziani, Nerea Blanes Ruiz, Bruce M Cattanach, Alexander N Young, Manish Kumar, Andrea Cerase, Phil Avner

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Compensation of gene dosage on the mammalian X.Development (Cambridge, England) · 2024
    Review
  5. Review
  6. Review
  7. Review
  8. Emerging roles of long non-coding RNA FTX in human disorders.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023
    Review
  9. A Global Survey of the Full-Length Transcriptome ofInternational journal of molecular sciences · 2023
    Article
  10. Lppnx lncRNA: The new kid on the block or an old friend in X-inactivation choice?Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  11. Reply to Galupa et al: Discussing the role of Lppnx in the complexity of the X controlling element, Xce.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 4 countries.

Andreas HierholzerEpigenetics and Neurobiology Unit, EMBL Rome, Monterotondo, 00015, Italy.ORCID 0000-0001-6008-8663
Corinne ChureauGenomics and Epigenomics of Animal Development, Developmental and Stem Cell Biology Department, Institut Pasteur, 75015 Paris, France.
Alessandra LiverzianiEpigenetics and Neurobiology Unit, EMBL Rome, Monterotondo, 00015, Italy.
Nerea Blanes RuizBlizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, E1 2AT, United Kingdom.
Bruce M CattanachMammalian Genetics Unit, MRC Harwell, Oxfordshire OX11 0RD, United Kingdom.
Alexander N YoungEpigenetics and Neurobiology Unit, EMBL Rome, Monterotondo, 00015, Italy.
Manish KumarEpigenetics and Neurobiology Unit, EMBL Rome, Monterotondo, 00015, Italy.
Andrea CeraseEpigenetics and Neurobiology Unit, EMBL Rome, Monterotondo, 00015, Italy.ORCID 0000-0002-1985-2049
Phil AvnerEpigenetics and Neurobiology Unit, EMBL Rome, Monterotondo, 00015, Italy.
Stowers Institute for Medical Research · USUniversity of Pisa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

X chromosome inactivation (XCI) is the process of silencing one of the X chromosomes in cells of the female mammal which ensures dosage compensation between the sexes. Although theoretically random in somatic tissues, the choice of which X chromosome is chosen to be inactivated can be biased in mice by genetic element(s) associated with the so-called X-controlling element (

Indexed as

RNA, Long NoncodingX Chromosome InactivationAllelesAnimalsDosage Compensation, GeneticFemaleMammalsMiceX ChromosomeRNA, Long NoncodingXIST non-coding RNAfemale mouse embryononcoding RNApluripotency factorsX chromosome inactivationX-controlling element

Identifiers

PMID35787055
PMCPMC9282422
OpenAlexW4283827810

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.