Evidence map›Paper›PMID 35787040›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

A conserved signal-peptidase antagonist modulates membrane homeostasis of actinobacterial sortase critical for surface morphogenesis.

Nicholas A Ramirez, Chenggang Wu, Chungyu Chang, Sara D Siegel, Asis Das, Hung Ton-That

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Nicholas A RamirezMolecular Biology Institute, University of California, Los Angeles, Los Angeles, CA.ORCID 0000-0001-9374-1446
Chenggang WuDepartment of Microbiology & Molecular Genetics, University of Texas McGovern Medical School, Houston, TX.ORCID 0000-0002-5700-7188
Chungyu ChangDivision of Oral Biology and Medicine, School of Dentistry, University of California, Los Angeles, CA.ORCID 0000-0001-6127-3086
Sara D SiegelDepartment of Microbiology & Molecular Genetics, University of Texas McGovern Medical School, Houston, TX.
Asis DasDepartment of Medicine, Neag Cancer Center, University of Connecticut Health Center, Farmington, CT.
Hung Ton-ThatMolecular Biology Institute, University of California, Los Angeles, Los Angeles, CA.ORCID 0000-0003-1611-0469
University of California, Los Angeles · USUConn Health · US

Funding

MULTIDISCIPLINARY TRAINING IN MICROBIAL PATHOGENESIST32AI007323 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Peter John Bradley · 1988 to 2026
$8.6M
Molecular Assembly on the Cell Surface of ActinomycesR01DE017382 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Hung Ton-That · 2008 to 2026
$6.7M
Post-translocational protein folding in Gram-positive bacteriaR01DE025015 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI TON-THAT, HUNG · 2015 to 2024
$3.9M
Mechanism and function of membrane homeostasis of sortase modulated by an evolutionarily conserved protein involved in pilus assembly in Gram-positive bacteriaF31DE031500 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RAMIREZ, NICHOLAS ANTHONY · 2021 to 2021
$16k
NIAID NIH HHS T32 AI007323NIDCR NIH HHS F31 DE031500NIDCR NIH HHS R01 DE017382NIDCR NIH HHS R01 DE025015
6 · The paper itself

Abstract

Most Actinobacteria encode a small transmembrane protein, whose gene lies immediately downstream of the housekeeping sortase coding for a transpeptidase that anchors many extracellular proteins to the Gram-positive bacterial cell wall. Here, we uncover the hitherto unknown function of this class of conserved proteins, which we name SafA, as a topological modulator of sortase in the oral Actinobacterium

Indexed as

AminoacyltransferasesActinobacteriaBacterial ProteinsCysteine EndopeptidasesHomeostasisMembrane ProteinsMorphogenesisSerine EndopeptidasesAminoacyltransferasesBacterial ProteinsCysteine EndopeptidasesMembrane ProteinsSerine Endopeptidasestype I signal peptidaseactinobacteriaantagonismpilus assemblysignal peptidasesortase

Identifiers

PMID35787040
PMCPMC9282373
OpenAlexW4283830119

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.